MABS781 | Anti-COMP, clone EPR6289(2), Rabbit Monoclonal Antibody

100 µL  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, FCRbUnpurifiedMonoclonal Antibody
      Catalogue NumberMABS781
      DescriptionAnti-COMP, clone EPR6289(2), Rabbit Monoclonal Antibody
      Alternate Names
      • Cartilage oligomeric matrix protein
      • COMP
      • Thrombospondin-5
      • TSP5
      • COMP
      Background InformationCartilage oligomeric matrix protein or COMP or Thrombospondin-5 or TSP5, and encoded by the gene name COMP, COMP is a noncollagenous extracellular matrix (ECM) protein that belongs to the the thrombospondin gene family. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. COMP is usually found in the extracellular matrix and is regularly linked to cartilage tissue. COMP seems to protect chondrocytes against cell death, whether tumor necrosis factor alpha is present or not. Defects in COMP are the cause of multiple epiphyseal dysplasia type 1 and pseudoachondroplasia.
      Product Information
      PresentationRabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.
      ApplicationAnti-COMP, clone EPR6289(2), Rabbit Monoclonal Antibody is an antibody against COMP for use in Western Blotting, Flow Cytometry.
      Key Applications
      • Western Blotting
      • Flow Cytometry
      Application NotesFlow Cytometry Analysis: A 1:10-100 dilution from a representative lot detected COMP in Raji cells.

      Produced in collaboration with Epitomics™
      Biological Information
      ImmunogenSynthetic peptide corresponding to human COMP.
      ConcentrationPlease refer to lot specific datasheet.
      SpecificityDissociation constant (KD) is 5.10 x 10-11 M
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • COMP
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~82 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Raji, BxPC3, and Saos 2 cell lysates.

      Western Blotting Analysis: A 1:10,000-50,000 dilution of this antibody detected COMP in Raji, BxPC3, and Saos 2 cell lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information

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      Life Science Research > Antibodies and Assays > Primary Antibodies