ABC460 | Anti-Sec23B Antibody

ABC460
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC460
      DescriptionAnti-Sec23B Antibody
      Alternate Names
      • Tumor-associated calcium signal transducer 2
      • Cell surface glycoprotein Trop-2
      • Membrane component chromosome 1 surface marker 1
      • Pancreatic carcinoma marker protein GA733-1
      Background InformationThe protein named Sec23B, also known as protein transport protein Sec23B, or SEC23-related protein B is a component of the COPII coat, the complex that governs ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. The transport of proteins in eukaryotic cells from the endoplasmic reticulum (ER) to the Golgi complex proceeds by deformation of specialized portions of the donor membrane to form carrier vesicles. A group of cytosolic proteins collectively known as COPII carry out a programmed set of sequential interactions, leading to cargo sorting and vesicle budding. The Sec23B protein is critical to proper protein transport in and out of cells, and it is localized to the smooth endoplasmic reticulum membrane where it is a peripheral membrane protein and interacts with the Golgi apparatus membranes as well. Sec23B is expressed at high levels in brain and fibroblasts as well as liver and other metabolically active tissues. Defects in Sec23B cause congenital dyserythropoietic anemia type II, a recessive disorder of erythroid differentiation but the disease is not caused by loss of function of Sec23B but rather a combination of a hypomorphic allele with altered functionality appears to be the cause and its related protein Sec23A can often compensate somewhat for the defect.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationDetect Sec23B using this rabbit polyclonal antibody, Anti-Sec23B Antibody validated for use in western blotting.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting Analysis: A representative lot from an independent laboratory detected Sec23B in various mouse tissue lysates expressing wild-type Sec23B. The same lot detected Sec23B in Sec23B wild-type MEF cell lysates and demonstrated a loss of signal in Sec23B knockdown MEF cell lysates (Tao, J., et al. (2012). Proc Natl Acad Sci USA. 109(29):E2001-E2009.).
      Biological Information
      ImmunogenLinear peptide corresponding to mouse Sec23B.
      HostRabbit
      Species Reactivity
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TACSTD2
      • GA733-1
      • M1S1
      • TROP2
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~86 kDa observed. Uncharacterized Band(s) may be observed in some cell lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse pancreas tissue lysate.

      Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Sec23B in 10 µg of mouse pancreas tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications