504713 | CPCCOEt - CAS 179067-99-3 - Calbiochem

504713
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₁₃H₁₃NO₄179067-99-3

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      5047130001
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          Glass bottle 5 mg
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          Description
          OverviewA potent, negative allosteric modulator selective for mGlu1 receptors (IC50 = 6.5 µM). No effect on other mGlu subtype receptors and ionotropic glutamate receptors at concentrations less than 100 µM. Acts by inhibiting an intramolecular interaction between the agonist-bound extracellular domain and the transmembrane domain. Widely used for studies related to peripheral pain and central pain pathways.
          Catalogue Number504713
          Brand Family Calbiochem®
          Synonyms(E)-Ethyl 1,1a,7,7a-tetrahydro-7-(hydroxyimino)cyclopropa[b]chromene-1a-carboxylate, mGlu₁ Antagonist, CPCCOEt
          References
          ReferencesLuongo L, et al. 2013. Neuropharmacol. 66, 317.
          Jin, Y., et al. 2012. Pain Res. Treat. 2012, 915706.
          Tappe-Theodor, A., 2011. Mol Pain. 7, 38.
          Litschig, S., et al. 1999. Mol. Pharmacol. 55, 453.
          Annoura, H., et al. 1996. Bioorg. Med. Chem. Lett. 6, 763.
          Product Information
          CAS number179067-99-3
          FormWhite powder
          Hill FormulaC₁₃H₁₃NO₄
          Chemical formulaC₁₃H₁₃NO₄
          Structure formula Image
          Applications
          Biological Information
          Primary TargetmGlu₁ receptors
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Luongo L, et al. 2013. Neuropharmacol. 66, 317.
          Jin, Y., et al. 2012. Pain Res. Treat. 2012, 915706.
          Tappe-Theodor, A., 2011. Mol Pain. 7, 38.
          Litschig, S., et al. 1999. Mol. Pharmacol. 55, 453.
          Annoura, H., et al. 1996. Bioorg. Med. Chem. Lett. 6, 763.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-July-2013 JSW
          Synonyms(E)-Ethyl 1,1a,7,7a-tetrahydro-7-(hydroxyimino)cyclopropa[b]chromene-1a-carboxylate, mGlu₁ Antagonist, CPCCOEt
          DescriptionA potent, negative allosteric modulator selective for mGlu1 receptors (IC50 = 6.5 µM). No effect on other mGlu subtype receptors and ionotropic glutamate receptors at concentrations less than 100 µM. Acts by inhibiting an intramolecular interaction between the agonist-bound extracellular domain and the transmembrane domain. Widely used for studies related to peripheral pain and central pain pathways.
          FormWhite powder
          CAS number179067-99-3
          Chemical formulaC₁₃H₁₃NO₄
          Structure formula
          Purity≥98% by HPLC
          SolubilityDMSO (100 mM)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesLuongo L, et al. 2013. Neuropharmacol. 66, 317.
          Jin, Y., et al. 2012. Pain Res. Treat. 2012, 915706.
          Tappe-Theodor, A., 2011. Mol Pain. 7, 38.
          Litschig, S., et al. 1999. Mol. Pharmacol. 55, 453.
          Annoura, H., et al. 1996. Bioorg. Med. Chem. Lett. 6, 763.