121761 AG 957

121761
  
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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.

      We apologize for the inconvenience, but we do not currently have an alternative product. Please refer to our complete listing of protein tyrosine kinase inhibitors for possible alternatives. Please read the alternative product documentation carefully and contact technical service if you need additional information.





      A potent tyrosine kinase inhibitor. Selectively blocks the tyrosine kinase activity of human p210bcr-abl (Ki = 750 nM) over p140c-abl (Ki = 10 µM). Also decreases p210bcr-abl phosphorylation in viable K562 cells at concentrations and durations of exposure that also inhibit cell proliferation. Reported to alter the physical state of p210bcr-abl and the association of p210bcr-abl with Shc and Grb2 in K562 cells.
      Catalogue Number121761
      Brand Family Calbiochem®
      Synonyms4-Amino-N-(2,5-dihydroxybenzyl)methyl benzoate, NSC 654705
      References
      ReferencesBhatia, R., et al. 1998. Leukemia 12, 1708. Kaur, G., and Sausville, E.A. 1996. Anticancer Drugs 7, 815. Anafi, M., et al. 1992. J. Biol. Chem. 267, 4518.
      Product Information
      FormOff-white solid
      Hill FormulaC₁₅H₁₅NO₄
      Chemical formulaC₁₅H₁₅NO₄
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary Targetp210bcr-abl
      Primary Target K<sub>i</sub>750 nM
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      121761

      References

      Reference overview
      Bhatia, R., et al. 1998. Leukemia 12, 1708. Kaur, G., and Sausville, E.A. 1996. Anticancer Drugs 7, 815. Anafi, M., et al. 1992. J. Biol. Chem. 267, 4518.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-April-2008 RFH
      Synonyms4-Amino-N-(2,5-dihydroxybenzyl)methyl benzoate, NSC 654705
      DescriptionA potent tyrosine kinase inhibitor. Selectively blocks the tyrosine kinase activity of human p210brc-abl (Ki = 750 nM) over p140c-abl (Ki = 10 µM). Also decreases p210brc-abl phosphorylation in living K562 cells at a concentration and duration of exposure that also inhibits cell proliferation. It has recently been shown that AG 957 can alter the physical state of p210bcr-abl and the association of p210brc-abl with Shc and Grb2 in K562 cells.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₅H₁₅NO₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (200 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBhatia, R., et al. 1998. Leukemia 12, 1708. Kaur, G., and Sausville, E.A. 1996. Anticancer Drugs 7, 815. Anafi, M., et al. 1992. J. Biol. Chem. 267, 4518.