116813 Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-Bromo-2ʹ-monobutyryl-, Rp-Isomer, Sodium Salt

116813
  
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      Overview

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      Description
      Overview

      This product has been discontinued.

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      A cell-permeable and reversible inhibitor of protein kinase A that is reported to block the excitatory effect of 8-Bromo-cGMP and to inhibit the basal Ca2+ currents in smooth muscle. More lipophilic and cell permeable than Rp-8-Bromo-cAMP (Cat. No. 116816).
      Note: 5 µmol = 2.58 mg.
      Catalogue Number116813
      Brand Family Calbiochem®
      SynonymsRp-8-Br-MB-cAMPS, Na
      References
      ReferencesRuiz-Velasco, V., et al. 1998. Circ. Res. 82, 557.
      Product Information
      DeclarationSold under license of Patent DE 3,802,865.4 issued to BIOLOG LSI.
      FormWhite lyophilized solid
      Hill FormulaC₁₄H₁₆BrN₅O₆PS · Na
      Chemical formulaC₁₄H₁₆BrN₅O₆PS · Na
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetPKA
      Secondary targetBasal Ca2+ current in smooth muscle
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C or -70°C). Stock solutions are stable for up to 1 month at -20°C or up to 6 months at -70°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      116813

      References

      Reference overview
      Ruiz-Velasco, V., et al. 1998. Circ. Res. 82, 557.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-September-2007 RFH
      SynonymsRp-8-Br-MB-cAMPS, Na
      DescriptionAn inhibitor of protein kinase A that also inhibits the basal Ca2+ currents in smooth muscle. Reported to block the excitatory effect of 8-Bromo-cGMP (Cat No. 203820). More lipophilic and cell-permeable than Rp-8-Br-cAMPS (Cat. No. 116816).
      FormWhite lyophilized solid
      Chemical formulaC₁₄H₁₆BrN₅O₆PS · Na
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityH₂O (10 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C or -70°C). Stock solutions are stable for up to 1 month at -20°C or up to 6 months at -70°C.
      Toxicity Standard Handling
      ReferencesRuiz-Velasco, V., et al. 1998. Circ. Res. 82, 557.