119151 Adenosine A2B Receptor Antagonist I, MRS 1754 - CAS 264622-58-4 - Calbiochem

119151
  
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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.



      A p-cyanoanilide xanthine derivative that acts as a highly selective, high affinity antagonist of adenosine A2B receptor (A2BR; Ki = 1.97 nM for human A2BR). Does not significantly affect other adenosine receptors (Ki = 403 nM, 503 nM, and 570 nM for human A1R, A2AR, and A3R, respectively). Exhibits some antagonist action on rat A1R (Ki = 16.8 nM). Shown to abolish the cardioprotective effects of NECA (Cat. No. 119140).

      Catalogue Number119151
      Brand Family Calbiochem®
      Synonyms8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine, MRS-1754, MRS1754
      References
      ReferencesJi, X., et al. 2001. Biochem Pharmacol. 61, 657.
      Philipp, S., et al. 2006. Cardiovasc Res. 70, 308.
      Kim, Y. C., et al. 2000. J Med Chem. 43, 1165.
      Kreckler, L. M., et al. 2006. J Pharmacol Exp Ther. 331.
      Ma, D.F., et al. 2010. Hum Pathol. 41, 1550.
      Product Information
      CAS number264622-58-4
      FormWhite solid
      Hill FormulaC₂₆H₂₆N₆O₄
      Chemical formulaC₂₆H₂₆N₆O₄
      ReversibleY
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetAdenosine A2B Receptor
      Primary Target K<sub>i</sub>1.97 nM
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      119151

      References

      Reference overview
      Ji, X., et al. 2001. Biochem Pharmacol. 61, 657.
      Philipp, S., et al. 2006. Cardiovasc Res. 70, 308.
      Kim, Y. C., et al. 2000. J Med Chem. 43, 1165.
      Kreckler, L. M., et al. 2006. J Pharmacol Exp Ther. 331.
      Ma, D.F., et al. 2010. Hum Pathol. 41, 1550.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-March-2013 JSW
      Synonyms8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine, MRS-1754, MRS1754
      DescriptionA p-cyanoanilide xanthine derivative that acts as a highly selective, high affinity antagonist of adenosine A2B receptor (A2BR; Ki = 1.97 nM for human A2BR). Does not significantly affect other adenosine receptors (Ki = 403 nM, 503 nM, and 570 nM for human A1R, A2AR, and A3R, respectively). Exhibits some antagonist action on rat A1R (Ki = 16.8 nM). Shown to abolish the cardioprotective effects of NECA (Cat. No. 119140).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number264622-58-4
      Chemical formulaC₂₆H₂₆N₆O₄
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (50 mM)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesJi, X., et al. 2001. Biochem Pharmacol. 61, 657.
      Philipp, S., et al. 2006. Cardiovasc Res. 70, 308.
      Kim, Y. C., et al. 2000. J Med Chem. 43, 1165.
      Kreckler, L. M., et al. 2006. J Pharmacol Exp Ther. 331.
      Ma, D.F., et al. 2010. Hum Pathol. 41, 1550.