208710 [Ala²⁸⁶]-Ca2+/Calmodulin Kinase II Inhibitor 281-301

208710
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₁₀₈H₁₈₇N₃₉O₂₇S₂
      Description
      Overview

      This product has been discontinued.





      A synthetic peptide corresponding to residues 281-301 of the CaM kinase II α-subunit. Acts as a potent inhibitor of CaM kinase II catalytic fragment (IC50 = 2 µM). The inhibition is competitive with respect to ATP and noncompetitive with respect to peptide substrate.
      Catalogue Number208710
      Brand Family Calbiochem®
      SynonymsCaM Kinase II Inhibitor 281-301, MHRQEAVDCLKKFNARRKLKG-NH₂
      References
      ReferencesSmith, M.K., et al. 1992. J. Biol. Chem. 267, 1761.
      Colbran, R.J., et al. 1988. J. Biol. Chem. 264, 4800.
      Product Information
      ATP CompetitiveY
      FormLyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₀₈H₁₈₇N₃₉O₂₇S₂
      Chemical formulaC₁₀₈H₁₈₇N₃₉O₂₇S₂
      Sold on the basis of peptide contentY
      Applications
      Biological Information
      Primary Targetcam Kinase-2
      Primary Target IC<sub>50</sub>2 µM
      Purity≥95% by HPLC
      Physicochemical Information
      Peptide ContentY
      Peptide SequenceH-Met-His-Arg-Gln-Glu-Ala-Val-Asp-Cys-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-NH₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      208710

      References

      Reference overview
      Smith, M.K., et al. 1992. J. Biol. Chem. 267, 1761.
      Colbran, R.J., et al. 1988. J. Biol. Chem. 264, 4800.

      Brochure

      Title
      Calmodulin and Related Products Technical Bulletin
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-May-2008 RFH
      SynonymsCaM Kinase II Inhibitor 281-301, MHRQEAVDCLKKFNARRKLKG-NH₂
      DescriptionA synthetic peptide corresponding to residues 281-301 of the α subunit of CaM kinase II. Acts as a potent inhibitor (IC50 = 2 µM) of CaM kinase II catalytic fragment. Acts in a competitive manner with respect to ATP and in a noncompetitive manner with respect to peptide substrate. It contains the autoinhibitory domain of CaM kinase II, as well as the initial autophosphorylation site (Thr286).
      FormLyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Chemical formulaC₁₀₈H₁₈₇N₃₉O₂₇S₂
      Peptide SequenceH-Met-His-Arg-Gln-Glu-Ala-Val-Asp-Cys-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-NH₂
      Purity≥95% by HPLC
      SolubilityH₂O (5 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSmith, M.K., et al. 1992. J. Biol. Chem. 267, 1761.
      Colbran, R.J., et al. 1988. J. Biol. Chem. 264, 4800.