217642 Anti-CD11b Mouse mAb (ICRF44)

217642
  
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      Overview

      Replacement Information

      Key Spec Table

      Host
      M
      Description
      Overview

      This product has been discontinued.





      Recognizes the ~165 kDa αM integrin subunit. Also blocks homotypic neutrophil and fMLP-induced monocyte aggregation.
      Catalogue Number217642
      Brand Family Calbiochem®
      SynonymsAnti-αM Integrin, Anti-CR3, Anti-Mac-1
      References
      ReferencesPetty, H.R., and Todd, R.F. 1993. J. Leukoc. Biol. 54, 492.
      Myones, B.L., et al. 1988. J. Clin. Invest. 82, 640.
      Malhotra, V., et al. 1986. Eur. J. Immunol. 16, 1117.
      Product Information
      FormLiquid
      FormulationIn 150 mM NaCl, 100 mM potassium chloride, 50 mM sodium phosphate, pH 7.5.
      Preservative≤0.1% sodium azide
      Applications
      Key Applications Immunoprecipitation
      Cell Inhibition Assays
      Flow Cytometry
      Frozen Sections
      Application NotesFlow Cytometry (5-20 µg/ml)
      Frozen Sections (see comments)
      Cell Inhibition Assays (see comments)
      Immunoprecipitation (see comments)
      Application CommentsMay be used to block homotypic neutrophil and monocyte (fLMP-induced) aggregation. This antibody has been reported to work for frozen sections and immunoprecipitation. Variables associated with assay conditions will dictate the proper working dilution.
      Biological Information
      Immunogenhuman monocytes DO NOT REACTIVATE. REMOVED FROM WEBSITE PER MAR/COM eCOMMERCE REQUEST. ALREADY DISCONTINUED. See PCS CBC-2015-6926. MJ 2-18-15
      ImmunogenHuman
      CloneICRF44
      HostMouse
      Purity≥95% by SDS-PAGE
      IsotypeIgG₁
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and freeze (-20°C) for long-term storage. Avoid freeze/thaw cycles.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      217642

      References

      Reference overview
      Petty, H.R., and Todd, R.F. 1993. J. Leukoc. Biol. 54, 492.
      Myones, B.L., et al. 1988. J. Clin. Invest. 82, 640.
      Malhotra, V., et al. 1986. Eur. J. Immunol. 16, 1117.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-July-2007 RFH
      SynonymsAnti-αM Integrin, Anti-CR3, Anti-Mac-1
      ApplicationFlow Cytometry (5-20 µg/ml)
      Frozen Sections (see comments)
      Cell Inhibition Assays (see comments)
      Immunoprecipitation (see comments)
      DescriptionProtein A purified mouse monoclonal antibody. Recognizes the ~165 kDa αM integrin subunit (CD11b).
      BackgroundCD11b complexes with CD18 (β2 integrin) to form the complement receptor type 3 (CR3) heterodimer which binds ICAM, fibrinogen, C3b, and coagulation factor X. CD11b expression is restricted to leukocytes, mainly to myeloid and NK cells.
      HostMouse
      Immunogen speciesHuman
      Immunogenhuman monocytes DO NOT REACTIVATE. REMOVED FROM WEBSITE PER MAR/COM eCOMMERCE REQUEST. ALREADY DISCONTINUED. See PCS CBC-2015-6926. MJ 2-18-15
      CloneICRF44
      IsotypeIgG₁
      Specieshuman
      FormLiquid
      FormulationIn 150 mM NaCl, 100 mM potassium chloride, 50 mM sodium phosphate, pH 7.5.
      Concentration Label Please refer to vial label for lot-specific concentration
      Purity≥95% by SDS-PAGE
      Preservative≤0.1% sodium azide
      CommentsMay be used to block homotypic neutrophil and monocyte (fLMP-induced) aggregation. This antibody has been reported to work for frozen sections and immunoprecipitation. Variables associated with assay conditions will dictate the proper working dilution.
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and freeze (-20°C) for long-term storage. Avoid freeze/thaw cycles.
      Toxicity Standard Handling
      ReferencesPetty, H.R., and Todd, R.F. 1993. J. Leukoc. Biol. 54, 492.
      Myones, B.L., et al. 1988. J. Clin. Invest. 82, 640.
      Malhotra, V., et al. 1986. Eur. J. Immunol. 16, 1117.