178495 Apoptosis Activator IV, Apoptolidin

178495
  
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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.





      A cell-permeable macrolide antibiotic that induces apoptosis in E1A-transformed cells (IC50 = 11 ng/ml) with high selectivity. Although the apoptotic activity of apoptolidin correlates with its F0F1-ATPase inhibition (IC50 = 700 nM in yeast), the basis of the cancer selectivity is still not fully understood. Apoptolidin quickly isomerizes to and co-exists with Isoapoptolidin (Cat. No. 371959) in equilibrium (k1 = 0.0656 h-1 and Keq = 0.616 in Dulbecco's PBS at 37°C).
      Catalogue Number178495
      Brand Family Calbiochem®
      SynonymsApoptolidin, Nocardiopsis sp.
      References
      ReferencesDaniel, P.T., et al. 2006. Angew. Chem. Int. Ed. Engl. 45, 872.
      Wender, P.A., et al. 2002. Org. Lett. 4, 3819.
      Salomon, A.R., et al. 2001. Chem. Biol. 8, 71.
      Salomon, A.R., et al. Proc. Natl. Acad. Sci. USA 97, 14766.
      Kim, J.W., et al. 1997. J. Antibiot. 50, 628.
      Product Information
      CAS number194874-06-1
      FormWhite lyophilized solid
      Hill FormulaC₅₈H₉₆O₂₁
      Chemical formulaC₅₈H₉₆O₂₁
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      178495

      References

      Reference overview
      Daniel, P.T., et al. 2006. Angew. Chem. Int. Ed. Engl. 45, 872.
      Wender, P.A., et al. 2002. Org. Lett. 4, 3819.
      Salomon, A.R., et al. 2001. Chem. Biol. 8, 71.
      Salomon, A.R., et al. Proc. Natl. Acad. Sci. USA 97, 14766.
      Kim, J.W., et al. 1997. J. Antibiot. 50, 628.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-April-2008 RFH
      SynonymsApoptolidin, Nocardiopsis sp.
      DescriptionA cell-permeable macrolide antibiotic that induces apoptosis in E1A-transformed cells (IC50 = 11 ng/ml) with high selectivity. Although the apoptotic activity of apoptolidin correlates with its F0F1-ATPase inhibition (IC50 = 700 nM in yeast), the basis of the cancer selectivity is still not fully understood. Apoptolidin quickly isomerizes to and co-exists with Isoapoptolidin (Cat. No. 371959) in equilibrium (k1 = 0.0656 h-1 and Keq = 0.616 in Dulbecco's PBS at 37°C).
      FormWhite lyophilized solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number194874-06-1
      Chemical formulaC₅₈H₉₆O₂₁
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml), Ethanol (1 mg/ml), or Methanol (1 mg/ml)
      Storage -20°C
      Protect from moisture
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesDaniel, P.T., et al. 2006. Angew. Chem. Int. Ed. Engl. 45, 872.
      Wender, P.A., et al. 2002. Org. Lett. 4, 3819.
      Salomon, A.R., et al. 2001. Chem. Biol. 8, 71.
      Salomon, A.R., et al. Proc. Natl. Acad. Sci. USA 97, 14766.
      Kim, J.W., et al. 1997. J. Antibiot. 50, 628.