189483 Autocamtide-3

189483
  
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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.





      A synthetic substrate specific for Ca2+/calmodulin-dependent protein kinase II (CaMK II). The substrate sequence is based on the CaMKII pseudosubstrate core found within the autoinhibitory domain of the enzyme. Autophosphorylation of Thr286 within the autoinhibitory domain traps bound calmodulin by greatly reducing its dissociation rate, thus prolonging the active state.
      Catalogue Number189483
      Brand Family Calbiochem®
      SynonymsAC-3, KKALHRQETVDAL
      References
      ReferencesFluck, M., et al. 2000. J. Appl. Physiol. 88, 352.
      Yang, E., and Schulman, H. 1999. J. Biol. Chem. 274, 26199.
      Kahn, E.S., et al. 1998. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 119, 739.
      Product Information
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₆₅H₁₁₃N₂₁O₂₀
      Chemical formulaC₆₅H₁₁₃N₂₁O₂₀
      Hygroscopic Hygroscopic
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Peptide SequenceH-Lys-Lys-Ala-Leu-His-Arg-Gln-Glu-Thr-Val-Asp-Ala-Leu-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      189483

      References

      Reference overview
      Fluck, M., et al. 2000. J. Appl. Physiol. 88, 352.
      Yang, E., and Schulman, H. 1999. J. Biol. Chem. 274, 26199.
      Kahn, E.S., et al. 1998. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 119, 739.

      Brochure

      Title
      Calmodulin and Related Products Technical Bulletin
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-April-2008 RFH
      SynonymsAC-3, KKALHRQETVDAL
      DescriptionA synthetic substrate specific for Ca2+/calmodulin-dependent protein kinase II (CaMKII). The substrate sequence is based on the CaMKII pseudosubstrate core found within the auto-inhibitory domain of the enzyme. Autophosphorylation of Thr286 within the auto-inhibitory domain traps bound calmodulin by greatly reducing its dissociation rate, thus prolonging the active state.
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Recommended reaction conditionsMaximal CaMKII activity has been measured in reaction mixtures containing 50 mM PIPES, pH 7.0, 10 mM MgCl2, 0.1 mg/ml BSA, 0.5 mM CaCl2, 50 µM ATP containing [γ-32P]ATP, 1 µM calmodulin, and 20 µM Autocamtide-3.
      Chemical formulaC₆₅H₁₁₃N₂₁O₂₀
      Peptide SequenceH-Lys-Lys-Ala-Leu-His-Arg-Gln-Glu-Thr-Val-Asp-Ala-Leu-OH
      Purity≥98% by HPLC
      SolubilityH₂O (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesFluck, M., et al. 2000. J. Appl. Physiol. 88, 352.
      Yang, E., and Schulman, H. 1999. J. Biol. Chem. 274, 26199.
      Kahn, E.S., et al. 1998. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 119, 739.