197216 Bcl-xL Assay Substrate, Fluorogenic

197216
  
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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.





      A fluorescein-labeled Bad BH3 peptide that serves as an useful probe for investigating the nature of Bcl-xL- peptide interaction and as a substrate for high-throughput screening of Bcl-xL inhibitors based on fluorescence polarization. Interacts strongly with Bcl-xL with a Kd of 21.48 nM. The assay tolerates up to 8% DMSO.
      Catalogue Number197216
      Brand Family Calbiochem®
      SynonymsAc-NLWAAQRYGRELRRMSDK(fluorescein)FVD-OH
      References
      ReferencesZhang, H., et al. 2002. Anal. Biochem. 307, 70
      Product Information
      FormYello lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₃₇H₁₉₂N₃₈O₃₈S₂
      Chemical formulaC₁₃₇H₁₉₂N₃₈O₃₈S₂
      Hygroscopic Hygroscopic
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Emission max.
      Excitation max.
      Peptide SequenceAc-Asn-Leu-Trp-Ala-Ala-Gln-Arg-Tyr-Gly-Arg-Glu-Leu-Arg-Arg-Met-Ser-Asp-Lys(FITC-I)-Phe-Val-Asp-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      197216

      References

      Reference overview
      Zhang, H., et al. 2002. Anal. Biochem. 307, 70

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-April-2008 RFH
      SynonymsAc-NLWAAQRYGRELRRMSDK(fluorescein)FVD-OH
      DescriptionA Fluorescein-labeled Bad BH3 peptide that serves as a useful probe for investigating the nature of Bcl-xL peptide interaction. Also useful in fluorescence polarization assays for high-throughput screening of Bcl-xL inhibitors. Reported to exhibit strong interaction with Bcl-xL (Kd = 21.48 nM). Fluorescence polarization assay shown to tolerate up to 8% DMSO. Excitation max: ~485 nm; emission max: ~530 nm.
      FormYello lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₃₇H₁₉₂N₃₈O₃₈S₂
      Peptide SequenceAc-Asn-Leu-Trp-Ala-Ala-Gln-Arg-Tyr-Gly-Arg-Glu-Leu-Arg-Arg-Met-Ser-Asp-Lys(FITC-I)-Phe-Val-Asp-OH
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Toxicity Standard Handling
      ReferencesZhang, H., et al. 2002. Anal. Biochem. 307, 70