203294 Bisindolylmaleimide III, Hydrochloride

203294
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₂₃H₂₀N₄O₂ · HCl683775-59-9
      Description
      Overview

      This product has been discontinued.



      Please refer to our complete listing of bisindolylmaleimide compounds and other protein kinase C inhibitors for possible alternatives.






      A potent, cell-permeable, reversible, ATP-competitive and selective inhibitor of protein kinase C (IC50 = 26 nM). May inhibit protein kinase A at much higher concentrations (IC50 = 500 nM).
      Catalogue Number203294
      Brand Family Calbiochem®
      Synonyms2-[1-(3-Aminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide, HCl
      References
      ReferencesFabre, S., and Prudhomme, M. 1993. Bioorg. Med. Chem. 1, 193.
      Davis, P.D., et al. 1992. J. Med. Chem. 35, 177.
      Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
      Product Information
      CAS number683775-59-9
      FormRed solid
      Hill FormulaC₂₃H₂₀N₄O₂ · HCl
      Chemical formulaC₂₃H₂₀N₄O₂ · HCl
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetPKC
      Primary Target IC<sub>50</sub>26 nM
      Secondary targetPKA (IC₅₀ = 500 nM)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      203294

      References

      Reference overview
      Fabre, S., and Prudhomme, M. 1993. Bioorg. Med. Chem. 1, 193.
      Davis, P.D., et al. 1992. J. Med. Chem. 35, 177.
      Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-April-2011 RFH
      Synonyms2-[1-(3-Aminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide, HCl
      DescriptionA potent, cell-permeable, reversible, ATP-competitive and selective inhibitor of protein kinase C (IC50 = 26 nM). It also inhibits protein kinase A at much higher concentrations (IC50 = 500 nM).
      FormRed solid
      CAS number683775-59-9
      Chemical formulaC₂₃H₂₀N₄O₂ · HCl
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (200 mg/ml) or H₂O (1 mg/ml). Slight warming may be required for complete solubilization in water.
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesFabre, S., and Prudhomme, M. 1993. Bioorg. Med. Chem. 1, 193.
      Davis, P.D., et al. 1992. J. Med. Chem. 35, 177.
      Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.