203675 Bombesin, Free Base

203675
  
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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.

      Please refer to our complete listing of IP3 channel modulators for possible alternatives. Please read the alternative product documentation carefully and contact technical service if you need additional information.





      A tetradecapeptide that activates a cascade of biochemical reactions including Ins(1,4,5)P3-induced mobilization of intracellular Ca2+, protein kinase C activation, Na+,and K+ fluxes, and cAMP production. Potent mitogen of Swiss/3T3 cells. Stimulates phospholipase D in Swiss/3T3 fibroblasts.
      Catalogue Number203675
      Brand Family Calbiochem®
      SynonymsH-Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH₂
      References
      ReferencesOlivier, A.R., et al. 1996. Biochem. J. 318, 519.
      Wang, J.L., et al. 1996. Biochem. J. 320, 87.
      Briscoe, C.P., et al. 1995. Biochem. J. 306, 115.
      Mulholland, M.W., and Simeone, D.M. 1993. J. Surg. Res. 54, 389.
      Agostinis, P., et al. 1992. J. Biol. Chem. 267, 9732.
      Currie, S., et al. 1992. J. Biol. Chem. 267, 6056.
      Alexander, R.W., et al. 1988. Cancer Res. 48, 1439.
      Panula, P. 1986. Med. Biol. 64, 177.
      Product Information
      CAS number31362-50-2
      FormWhite to off-white lyophilized solid
      Hill FormulaC₇₁H₁₁₀N₂₄O₁₈S
      Chemical formulaC₇₁H₁₁₀N₂₄O₁₈S
      Hygroscopic Hygroscopic
      Sold on the basis of peptide contentY
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Peptide ContentY
      Peptide SequenceH-Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH₂ (Pyr = 5-oxoPro)
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSBD3480000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      203675

      References

      Reference overview
      Olivier, A.R., et al. 1996. Biochem. J. 318, 519.
      Wang, J.L., et al. 1996. Biochem. J. 320, 87.
      Briscoe, C.P., et al. 1995. Biochem. J. 306, 115.
      Mulholland, M.W., and Simeone, D.M. 1993. J. Surg. Res. 54, 389.
      Agostinis, P., et al. 1992. J. Biol. Chem. 267, 9732.
      Currie, S., et al. 1992. J. Biol. Chem. 267, 6056.
      Alexander, R.W., et al. 1988. Cancer Res. 48, 1439.
      Panula, P. 1986. Med. Biol. 64, 177.

      Brochure

      Title
      Calcium Metabolism and Related Products Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-April-2008 RFH
      SynonymsH-Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH₂
      DescriptionA tetradecapeptide that activates a cascade of biochemical reactions including Ins(1,4,5)P3-induced mobilization of intracellular Ca2+, Na+ and K+ fluxes, protein kinase C activation, and cAMP production. Acts as a mitogen and growth factor for cells in culture. The bombesin receptor in Swiss 3T3 cells is a G-protein linked neuropeptide receptor. Stimulates phospholipase D and phospholipase A2 activity in Swiss 3T3 fibroblasts. Increases the release of acetylcholine from myenteric plexus neurons via a PKC-dependent mechanism. Stimulates pancreatic growth, hypothermia, hypoglycemia, and satiety in mammals. Stimulates hormone secretion by the gastrointestinal tract, including gastrin, cholecystokinin, insulin, glucagon, prolactin, and growth hormone.
      FormWhite to off-white lyophilized solid
      CAS number31362-50-2
      RTECSBD3480000
      Chemical formulaC₇₁H₁₁₀N₂₄O₁₈S
      Peptide SequenceH-Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH₂ (Pyr = 5-oxoPro)
      Purity≥97% by HPLC
      Solubility5% Acetic acid (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      Merck USA index14, 1329
      ReferencesOlivier, A.R., et al. 1996. Biochem. J. 318, 519.
      Wang, J.L., et al. 1996. Biochem. J. 320, 87.
      Briscoe, C.P., et al. 1995. Biochem. J. 306, 115.
      Mulholland, M.W., and Simeone, D.M. 1993. J. Surg. Res. 54, 389.
      Agostinis, P., et al. 1992. J. Biol. Chem. 267, 9732.
      Currie, S., et al. 1992. J. Biol. Chem. 267, 6056.
      Alexander, R.W., et al. 1988. Cancer Res. 48, 1439.
      Panula, P. 1986. Med. Biol. 64, 177.