CC1010 GM6001 MMP Inhibitor

10 mg  
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      Replacement Information
      Catalogue NumberCC1010
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionGM6001 MMP Inhibitor
      OverviewSpecificity: GM6001 MMP inhibitor, also known as Ilomastat or N-[(2R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan methylamide, is a potent inhibitor of collagenases. Molecular weight: 388.47

      Reported Ki values are as follows (see Galardy Ref):·

      Human MMP-1 (Fibroblast collagenase): 0.4 nM·

      Human MMP-3 (Stromelysin): 27 nM·

      Human MMP-2 (72 kDa gelatinase): 0.5 nM·

      Human MMP-8 (Neutrophil collagenase): 0.1 nM·

      Human MMP-9 (92 kDa gelatinase): 0.2 nM

      Typical working dilution for use in cultured cells is 10-25 μM. GM6001 will precipitate from aqueous solutions exceeding 100μM. Aqueous dilutions should be performed using low salt buffers to prevent precipitation of GM6001 from solution (Recommended dilution buffer: 50 mM Tris pH7.5, 150 mM NaCl, and 20 mM CaCl2.2H20). It is recommended that the concentration of GM6001 in aqueous working solutions is determined upon dilution and confirmed prior to each use. Additional Application information:
      Use in vivo
      Typical dosage for GM6001 in animals is 50-100mg/kg body weight. It is generally administered IP every day or every other day. It is thought to cross the blood brain barrier since studies have shown it effectiveness in MS models.

      If delivered by I.V. the half life in an animal is approximate an hour so it will have to be administered quite often. Thus the preferred way is to deliver the drug by I.P as a suspension in water or saline. The half life does not change but because it is dissolving in the animal's system slowly, administration is not done as frequently. It has to be redelivered every other day or so. It can also be delivered subcutaneously in a saline suspension. The drug will precipitate as stay as a mass within the tissue, but surprisingly enough does get into the animal system to be effective.

      Soluble up to at least 400mg/ml in DMSO. It can then be diluted in water and must be mixed very quickly to avoid precipitation.

      GM6001 in DMSO or Water at a concentration of 1mM (0.1mM is preferred) decomposes at the rate of 1% per month at 4%. At 37C this increases to 1% per day. At -20 it is quite stable and as a solid very highly stable
      Low salt buffers are recommended as diluents to reduce precipitation. Diluted solutions should never be frozen.

      Concentration of the stock solution should be periodically determined by absorbance at 280nm.
      Product Information
      PresentationProvided at 1 mg/mL (2.5 mM) in DMSO.
      ApplicationThe GM6001 MMP Inhibitor controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Biochemicals applications.
      Key Applications
      • Inhibits Activity/Function
      Biological Information
      Concentration1 mg/mL (2.5 mM) in DMSO
      Entrez Gene Number
      Entrez Gene SummaryProteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
      Gene Symbol
      • MMP1
      • CLG
      • MMP-1
      • CLGN
      • EC [Contains: 22 kDa interstitial collagenase
      • 27 kDa interstitial collagenase].
      Protein TargetInterstitial collagenase
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P22894 # Can degrade fibrillar type I, II, and III collagens.
      COFACTOR: Binds 3 calcium ions per subunit. & Binds 2 zinc ions per subunit.
      SIZE: 467 amino acids; 53412 Da
      SUBCELLULAR LOCATION: Cytoplasmic granule. Note=Stored in intracellular granules.
      TISSUE SPECIFICITY: Neutrophils.
      DOMAIN: SwissProt: P22894 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
      SIMILARITY: Belongs to the peptidase M10A family. & Contains 4 hemopexin-like domains.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain frozen at -20°C in DMSO for up to 12 months. Avoid storage once diluted into aqueous solutions.
      Packaging Information
      Material Size10 mg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      GM6001 Ilomastat (MMP Inhibitor)2982568
      GM6001 [Ilomastat] MMP Inhibitor2896400
      GM6001 [Ilomastat] MMP Inhibitor3073307
      GM6001 [Ilomastat] MMP Inhibitor3046825
      GM6001 [Ilomastat] MMP Inhibitor3143190
      GM6001 [Ilomastat] MMP Inhibitor - 21365982136598
      GM6001 [Ilomastat] MMP Inhibitor - 23877622387762
      GM6001 [Ilomastat] MMP Inhibitor - 23257342325734
      GM6001 [Ilomastat] MMP Inhibitor - 25648652564865
      GM6001 [Ilomastat] MMP Inhibitor - 31641803164180


      Reference overviewPub Med ID
      Apolipoprotein A-IV is a novel substrate for matrix metalloproteinases.
      Ji Yoon Park,Jun Hyoung Park,Wookju Jang,In-Kwan Hwang,In Ja Kim,Hwa-Jung Kim,Kyung-Hyun Cho,Seung-Taek Lee
      Journal of biochemistry  151  2012

      Show Abstract
      22170214 22170214
      Repair of bone defects using synthetic mimetics of collagenous extracellular matrices.
      Lutolf, Matthias P, et al.
      Nat. Biotechnol., 21: 513-8 (2003)  2003

      Show Abstract
      12704396 12704396
      Low molecular weight inhibitors in corneal ulceration.
      Galardy, R E, et al.
      Ann. N. Y. Acad. Sci., 732: 315-23 (1994)  1994

      7978801 7978801

      Data Sheet

      GM6001 [Ilomastat] MMP Inhibitor