194950 InSolution™ 3ʹ-Azido-3ʹ-Deoxythymidine, Triphosphate, Tetralithium Salt

194950
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₁₀H₁₂N₅O₁₃P₃ · 4Li
      Description
      Overview

      This product has been discontinued.





      A reverse transcriptase inhibitor that acts by docking to the active site of HIV reverse transcriptase. It's inhibitory effect is greater during the initiation phase of reverse transcription. Also reported to inhibit telomerase activity in vitro (IC50 = 30 µM). Acts synergistically with Cisplatin (Cat. No. 232120) to inhibit cell proliferation in some cell lines.
      Note: 1 µmol = 531 µg.
      Catalogue Number194950
      Brand Family Calbiochem®
      SynonymsAZTTP
      References
      ReferencesMickle, T., and Nair, V. 2000. Antimicrob. Agents Chemother. 44, 2939.
      Rigourd, M., et al. 2000. J. Biol. Chem. 275, 26944.
      Murakami, J., et al. 1999. Eur. J. Cancer 35, 1027.
      Strahl, C., and Blackburn, E.H. 1996. Mol. Cell. Biol. 16, 53.
      Strahl, C., and Blackburn, E.H. 1994. Nucleic Acids Res. 22, 893.
      Product Information
      FormLiquid
      FormulationA 100 mM solution in H₂O.
      Hill FormulaC₁₀H₁₂N₅O₁₃P₃ · 4Li
      Chemical formulaC₁₀H₁₂N₅O₁₃P₃ · 4Li
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary Targettelomerase activity
      Primary Target IC<sub>50</sub>30 µM
      Secondary targetreverse transcriptase
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 23/24/25

      Toxic by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36-45

      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage ≤ -70°C
      Protect from Light Protect from light
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      194950

      References

      Reference overview
      Mickle, T., and Nair, V. 2000. Antimicrob. Agents Chemother. 44, 2939.
      Rigourd, M., et al. 2000. J. Biol. Chem. 275, 26944.
      Murakami, J., et al. 1999. Eur. J. Cancer 35, 1027.
      Strahl, C., and Blackburn, E.H. 1996. Mol. Cell. Biol. 16, 53.
      Strahl, C., and Blackburn, E.H. 1994. Nucleic Acids Res. 22, 893.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-September-2007 RFH
      SynonymsAZTTP
      DescriptionA reverse transcriptase inhibitor that acts by docking to the active site of HIV-reverse transcriptase. Inhibitory effect is greater during the initiation phase of reverse transcription. Also reported to inhibit telomerase activity in vitro (IC50 = 30 µM). Acts synergistically with cisplatin to inhibit cell proliferation in some cell lines.
      FormLiquid
      FormulationA 100 mM solution in H₂O.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₀H₁₂N₅O₁₃P₃ · 4Li
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage ≤ -70°C
      Protect from light
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Toxic
      ReferencesMickle, T., and Nair, V. 2000. Antimicrob. Agents Chemother. 44, 2939.
      Rigourd, M., et al. 2000. J. Biol. Chem. 275, 26944.
      Murakami, J., et al. 1999. Eur. J. Cancer 35, 1027.
      Strahl, C., and Blackburn, E.H. 1996. Mol. Cell. Biol. 16, 53.
      Strahl, C., and Blackburn, E.H. 1994. Nucleic Acids Res. 22, 893.