FCMAB144F Milli-Mark Anti-RPA1 p70 -FITC Antibody, clone RPA9, 1-30

FCMAB144F
100 tests  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFCMFITCMonoclonal Antibody
      Description
      Catalogue NumberFCMAB144F
      Trade Name
      • Milli-Mark
      DescriptionMilli-Mark Anti-RPA1 p70 -FITC Antibody, clone RPA9, 1-30
      Alternate Names
      • RF-A protein 1
        RP-A p70
        Replication factor A protein 1
        Single-stranded DNA-binding protein
        replication protein A 70 kDa DNA-binding subunit
        replication protein A1 (70kD)
        replication protein A1, 70kDa
        replication protein A 70 kDa DNA-binding subunit
        REPA1
        RPA1
        HSSB.
      Background InformationReplication protein A (RPA) is a multisubunit complex involved in DNA mismatch repair (MMR) in association with MSH2, MLH1 , PCNA, and DNA polymerase-delta. RPA is a heterotrimer that includes subunits of 70 kDa (RPA1), 32kDa (RPA2), and 14kDa (RPA3). RPA1 p70 kDa is an ssDNA binding protein shown to be phosphorylated by ATM and ATR in response to DNA damage.RPA also functions in the initiation of DNA replication and DNA unwinding at origins of replication.
      References
      Product Information
      FormatFITC
      Control
      • HeLa Cells
      PresentationPurified mouse monoclonal IgG1κ conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
      Applications
      ApplicationMilli-Mark Anti-RPA1 p70 -FITC Antibody, clone RPA9, 1-30 is an antibody against RPA1 p70 for use in FC.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenHis-tagged recombinant protein corresponding to human RPA1.
      CloneRPA9, 1-30
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThis antibody recognizes RPA1
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • RPA1
      • REPA1
      • RF-A
      • RP-A
      • RPA70
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: It participates in a very early step in initiation. RP-A is a single-stranded DNA-binding protein. Absolutely required for simian virus 40 DNA replication in vitro.


      SUBUNIT STRUCTURE: Heterotrimer of 70, 32 and 14 kDa chains. The DNA-binding activity may reside exclusively on the 70 kDa subunit. Interacts with RIP and XPA. Interacts with RPA4.


      SUBCELLULAR LOCATION: Nucleus.


      PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.


      SEQUENCE SIMILARITIES: Belongs to the replication factor A protein 1 family.
      Molecular Weight ~68kDa Observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceTested by flow cytometry using HeLa Cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 tests
      Transport Information
      Supplemental Information
      Specifications

      Related Products & Applications

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      Catalogue Number Description  
      04-1521 Anti-RPA1 p70 Antibody, clone RPA9, 1-30 Show Pricing & Availability

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies