FCMAB122F | Milli-Mark™ Anti-c-Jun Antibody, clone 6E4, FITC Conjugate

FCMAB122F
100 tests  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RFCMFITCMonoclonal Antibody
      Description
      Catalogue NumberFCMAB122F
      Trade Name
      • Milli-Mark
      DescriptionMilli-Mark™ Anti-c-Jun Antibody, clone 6E4, FITC Conjugate
      Alternate Names
      • JNK1 alpha protein kinase
        JNK1 beta protein kinase
        JUN N-terminal kinase
        Stress-activated protein kinase JNK1
        c-Jun N-terminal kinase 1
        mitogen-activated protein kinase 8
        mitogen-activated protein kinase 8 isoform JNK1 alpha1
        mitogen-activated protein kinase 8 isoform JNK1 beta2
        protein kinase JNK1
      Background Informationc-Jun is a component of the transcription factor AP-1 that binds and activates transcription at TRE/AP-1 elements and appears to be a major downstream target of the SAPK/JNK signaling pathway. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73. Extracellular signals including growth factors, transforming oncoproteins and UV irradiation stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun dependent transcription. Mutation of Ser63/73 renders c-Jun nonresponsive to mitogenic and stress induced signaling pathways. The MAP kinase homologue, SAPK/JNK, binds to the N-terminal region of c-Jun and phosphorylates c-Jun at Ser63/73. In addition, the activity of SAPK/JNK is stimulated by the same signals that activate c-Jun.
      References
      Product Information
      FormatFITC
      Control
      • NIH/3T3 cells
      PresentationPurified mouse monoclonal IgG1κ conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
      Applications
      ApplicationMilli-Mark Anti-c-Jun Antibody, clone 6E4, FITC Conjugate is an antibody against c-Jun for use in FC.
      Key Applications
      • Flow Cytometry
      Working Solution Cells / test Total Reaction Volume
      5 μl 5 x 105 Cells / 95 μl PBS 100 μl
      10 μl 1 x 106 Cells / 90 μl PBS 100 μl
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to c-Jun.
      Clone6E4
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityAntibody recognizes c-Jun. .
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Species Reactivity NoteTested and passed on Mouse. Unconjugated antibody shown to work in Human, Mouse and Rat using ICC.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involvedin both translocations and deletions in human malignancies.
      Gene Symbol
      • EC 2.7.11.24
      • JNK
      • JNK-46
      • JNK1
      • JNK1A2
      • JNK21B1/2
      • OTTHUMP00000019552
      • OTTHUMP00000019555
      • OTTHUMP00000019556
      • OTTHUMP00000019558
      • PRKM8
      • SAPK1
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells By similarity. Phosphorylates heat shock factor protein 4 (HSF4).
      Molecular Weight 36-43kDa Observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by flow cytometry using NIH/3T3
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 tests
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Milli-Mark Anti-c-Jun-FITC, clone 6E4 - 1962101 1962101
      Milli-Mark Anti-c-Jun-FITC, clone 6E4 - 2179358 2179358
      Milli-Mark Anti-c-Jun-FITC, clone 6E4 - NG1861048 NG1861048
      Milli-Mark Anti-c-Jun-FITC, clone 6E4 - NRG1717747 NRG1717747
      Milli-Mark™ Anti-c-Jun-FITC, -2574858 2574858
      Milli-Mark™ Anti-c-Jun-FITC, -2788179 2788179
      Milli-Mark™ Anti-c-Jun-FITC, -2816680 2816680
      Milli-Mark™ Anti-c-Jun-FITC, clone 6E4 Conjugate 2941515
      Milli-Mark™ Anti-c-Jun-FITC,clone 6E4 -2667309 2667309
      Milli-Mark™ Anti-c-Jun-FITC, clone 6E4 - 2390905 2390905

      Brochure

      Title
      Benchtop Flow Cytometry Solutions Kits and Reagents
      Innovative Solutions for Flow Cytometry Analysis

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies