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852338 | Fmoc-thioproline

852338
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Hill FormulaMolar Mass
      133054-21-4C₁₉H₁₇N₄S355.41 g/mol

      Pricing & Availability

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      8523380001
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          Glass bottle 1 g
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          8523380005
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              Glass bottle 5 g
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              8523380025
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                  Glass bottle 25 g
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                  Description
                  Catalogue Number852338
                  Brand Family Novabiochem®
                  Alternate Names
                  • Fmoc-thiaproline,Fmoc-thiazolidine-4-carboxylic acid
                  Background InformationA building block for the intoduction of thiaproline (Thz) during Fmoc SPPS. Thz has been employed as a masked cysteine residue to prevent self-ligation during native chemical ligation reactions (NCL) of peptide thioesters bearing an N-terminal Cys residue [6]. Once ligation is complete, the N-terminal Cys residue of the resultant peptide is unmasked by ring opening the Thz residue by treatment with methoxyamine, thereby enabling its subsequent ligation to another peptide thioester fragment.
                  References
                  Product Information
                  CAS number133054-21-4
                  Hill FormulaC₁₉H₁₇N₄S
                  Molar Mass355.41 g/mol
                  HS Code2934 99 90
                  Structure formula Image
                  Applications
                  ApplicationFmoc-thioproline Novabiochem®. CAS 133054-21-4, molar mass 355.41 g/mol.
                  Biological Information
                  Physicochemical Information
                  Dimensions
                  Materials Information
                  Toxicological Information
                  Safety Information according to GHS
                  Storage class10 - 13 Other liquids and solids
                  WGKWGK 2 water endangering
                  Disposal3
                  Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.
                  Safety Information
                  Product Usage Statements
                  Storage and Shipping Information
                  StorageStore at -15°C to -25°C.
                  Packaging Information
                  Transport Information
                  Supplemental Information
                  Specifications
                  Colour (visual)white to slight yellow to beige
                  Appearance of substance (visual)powder
                  Identity (IR)passes test
                  Enantiomeric purity≥ 99.5 % (a/a)
                  Purity (TLC(011A))≥ 98 %
                  Assay (HPLC, area%)≥ 99.0 % (a/a)
                  Solubility (1 mmole in 2 ml DMF)clearly soluble
                  For TLC-Systems see our General Catalog

                  Documentation

                  SDS

                  Title

                  Safety Data Sheet (SDS) 

                  Certificates of Analysis

                  Product Number PackagingSpecificationLot Number
                  8523380001 Glass bottlePDF Specification Document
                  8523380005 Glass bottlePDF Specification Document
                  8523380025 Glass bottlePDF Specification Document

                  Citations

                  Title
                  [1] M. Villain, et al. in 'Peptides: The wave of the future, Proc. Second Int.& 17th American Peptide Symposium', M. Lebl & R A. Houghten (Eds), American peptide Society, 2001, pp. 107.

                  Reach Use

                  Title
                  Reach Use