559389 SB 203580 - CAS 152121-47-6 - Calbiochem

559389
Le prix n'a pas pu être récupéré
La quantité minimale doit être un multiple de
À la validation de la commande Plus d'informations
Vous avez sauvegardé ()
 
Demander le prix
Disponibilité limitéeDisponibilité limitée
En stock 
Interrompu(e)
Disponible en quantités limitées
Disponibilité à confirmer
    Pour le restant : Nous vous tiendrons informé
      Pour le restant : Nous vous tiendrons informé
      Nous vous tiendrons informé
      Contacter le Service Clients
      Contact Customer Service
      Voir les Prix & la Disponibilité
      Click To Print This Page

      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Empirical FormulaCAS #
      C₂₁H₁₆N₃OSF 152121-47-6

      Prix & Disponibilité

      RéférenceDisponibilité Conditionnement Qté Prix Quantité
      559389-10MG
      Récupération des données relatives à la disponibilité...
      Disponibilité limitéeDisponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
        Pour le restant : Nous vous tiendrons informé
          Pour le restant : Nous vous tiendrons informé
          Nous vous tiendrons informé
          Contacter le Service Clients
          Contact Customer Service

          Flacon en verre 10 mg
          Prix en cours de récupération
          Le prix n'a pas pu être récupéré
          La quantité minimale doit être un multiple de
          À la validation de la commande Plus d'informations
          Vous avez sauvegardé ()
           
          Demander le prix
          559389-1MG
          Récupération des données relatives à la disponibilité...
          Disponibilité limitéeDisponibilité limitée
          En stock 
          Interrompu(e)
          Disponible en quantités limitées
          Disponibilité à confirmer
            Pour le restant : Nous vous tiendrons informé
              Pour le restant : Nous vous tiendrons informé
              Nous vous tiendrons informé
              Contacter le Service Clients
              Contact Customer Service

              Ampoule plast. 1 mg
              Prix en cours de récupération
              Le prix n'a pas pu être récupéré
              La quantité minimale doit être un multiple de
              À la validation de la commande Plus d'informations
              Vous avez sauvegardé ()
               
              Demander le prix
              559389-5MG
              Récupération des données relatives à la disponibilité...
              Disponibilité limitéeDisponibilité limitée
              En stock 
              Interrompu(e)
              Disponible en quantités limitées
              Disponibilité à confirmer
                Pour le restant : Nous vous tiendrons informé
                  Pour le restant : Nous vous tiendrons informé
                  Nous vous tiendrons informé
                  Contacter le Service Clients
                  Contact Customer Service

                  Flacon en verre 5 mg
                  Prix en cours de récupération
                  Le prix n'a pas pu être récupéré
                  La quantité minimale doit être un multiple de
                  À la validation de la commande Plus d'informations
                  Vous avez sauvegardé ()
                   
                  Demander le prix
                  Description
                  OverviewReduces epirubicin-induced cell injury and caspase-3/7 activity. A highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 MAP kinase (IC50 = 34 nM in vitro, 600 nM in cells). Does not significantly inhibit the JNK and p42 MAP kinase at 100 µM. Inhibits IL-1 and TNF-α production from LPS-stimulated human monocytes and the human monocyte cell line THP-1 (IC50 = 50-100 nM). Inhibits bone morphogenetic protein-2-induced neurite outgrowth in PC12 cells. Also inhibits platelet aggregation caused by collagen (IC50 = 0.2-1.0 µM) or the thromboxane analog U-46619 (Cat. No. 538944). A 1 mg/ml solution of SB 203580 (Cat. No. 559398) in anhydrous DMSO is also available.
                  Catalogue Number559389
                  Brand Family Calbiochem®
                  Synonyms4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole, p38 MAP Kinase Inhibitor XVI
                  References
                  ReferencesYamada. T., et al. 2012. Free Radic. Biol. Med. (In press)
                  Powell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
                  Davies, S.P., et al. 2000. Biochem. J. 351, 95.
                  Iwasaki, S., et al. 1999. J. Biol. Chem. 274, 26503.
                  Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
                  LoGrasso, P.V., et al. 1997. Biochem. 36, 10422.
                  Hazzalin, C.A., et al. 1996. Curr. Biol. 6, 1028.
                  Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723.
                  Saklatvala, J., et al. 1996. J. Biol. Chem. 271, 6586.
                  Cuenda, A., et al. 1995. FEBS Lett. 364, 229.
                  Gallagher, T.F., et al. 1995. Bioorg. Med. Chem. Lett. 5, 1171.
                  Lee, J.C., et al. 1994. Nature 372, 739.
                  Product Information
                  CAS number152121-47-6
                  ATP CompetitiveY
                  FormThin film
                  Hill FormulaC₂₁H₁₆N₃OSF
                  Chemical formulaC₂₁H₁₆N₃OSF
                  ReversibleY
                  Structure formula ImageStructure formula Image
                  Applications
                  ApplicationSB 203580, CAS 152121-47-6, is a highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 MAP kinase (IC₅₀ = 34 nM in vitro, 600 nM in cells).
                  Biological Information
                  Primary TargetP38MAPK
                  Primary Target IC<sub>50</sub>34 nM against p38 MAP kinase in vitro, 600 nM in cells; 50-100 nM against IL-1 and TNF-α production from LPS-stimulated human monocytes and the human monocyte cell line THP-1; 0.2-1.0 µM against platelet aggregation caused by collagen
                  Purity≥98% by HPLC
                  Physicochemical Information
                  Cell permeableY
                  Dimensions
                  Materials Information
                  Toxicological Information
                  Safety Information according to GHS
                  Safety Information
                  R PhraseR: 36/37/38

                  Irritating to eyes, respiratory system and skin.
                  S PhraseS: 26-36-45

                  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
                  Wear suitable protective clothing.
                  In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
                  Product Usage Statements
                  Storage and Shipping Information
                  Ship Code Ambient Temperature Only
                  Toxicity Irritant
                  Storage -20°C
                  Protect from Light Protect from light
                  Do not freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
                  Packaging Information
                  Transport Information
                  Supplemental Information
                  Specifications

                  Documentation

                  FDS

                  Titre

                  Fiche de données de sécurité des matériaux (FDS) 

                  Certificats d'analyse

                  TitreNuméro de lot
                  559389

                  Références bibliographiques

                  Aperçu de la référence bibliographique
                  Yamada. T., et al. 2012. Free Radic. Biol. Med. (In press)
                  Powell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
                  Davies, S.P., et al. 2000. Biochem. J. 351, 95.
                  Iwasaki, S., et al. 1999. J. Biol. Chem. 274, 26503.
                  Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
                  LoGrasso, P.V., et al. 1997. Biochem. 36, 10422.
                  Hazzalin, C.A., et al. 1996. Curr. Biol. 6, 1028.
                  Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723.
                  Saklatvala, J., et al. 1996. J. Biol. Chem. 271, 6586.
                  Cuenda, A., et al. 1995. FEBS Lett. 364, 229.
                  Gallagher, T.F., et al. 1995. Bioorg. Med. Chem. Lett. 5, 1171.
                  Lee, J.C., et al. 1994. Nature 372, 739.

                  Brochure

                  Titre
                  MAP Kinases Technical Bulletin

                  Citations

                  Titre
                • Yamada. T., et al. 2012. Free Radic. Biol. Med. (In press)
                • Satoshi Fukumoto, et al. (2006) Laminin 5 is required for dental epithelium growth and polarity and the development of tooth bud and shape. Journal of Biological Chemistry 281, 5008-5016.
                • Alexandra Thiel, et al. (2006) Expression of Cyclooxygenase-2 Is Regulated by Glycogen Synthase Kinase-3beta in Gastric Cancer Cells. Journal of Biological Chemistry 281, 4564-4569.
                • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.
                • Bysani Chandrasekar, et al. (2005) The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-J. Journal of Biological Chemistry 280, 26263-26277.
                • Guadalupe Sabio, et al. (2005) p38γ regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP. The EMBO Journal 24, 1134-1145.
                • Jose G. Trevino, et al. (2005) Expression and activity of Src regulate interleukin-8 expression in pancreatic adenocarcinoma cells: implications for angiogenesis. Cancer Research 65, 7214-7222.
                • Wojciech Wojciechowski, et al. (2005) Enhanced Expression of CD20 in Human Tumor B Cells is Controlled Through ERK-Dependent Mechanisms. Journal of Immunology 174, 7859-7868.
                • Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.
                • Naoto Inukai, et al. (2004) A novel hydrogen peroxide-induced phosphorylation and ubiquitination pathway leading to RNA polymerase II proteolysis. Journal of Biological Chemistry 279, 8190-8195.
                • Fiche technique

                  Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                  Revision28-February-2012 RFH
                  Synonyms4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole, p38 MAP Kinase Inhibitor XVI
                  DescriptionReduces epirubicin-induced cell injury and caspase-3/7 activity. A highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 kinase (IC50 = 34 nM in vitro, 600 nM in cells). Also known as reactivating kinase (RK) and CSBP (cytokine synthesis anti-inflammatory drug binding protein). Does not significantly inhibit JNK or p42 MAP kinase even at 100 µM. Inhibits IL-1 and TNF-α production from LPS-stimulated human monocytes and the human monocyte cell line THP-1 (IC50 = 50-100 nM). SB 203580 has also been shown to be an effective inhibitor of inflammatory cytokine production in vivo in both mice and rats.
                  FormThin film
                  CAS number152121-47-6
                  Chemical formulaC₂₁H₁₆N₃OSF
                  Structure formulaStructure formula
                  Purity≥98% by HPLC
                  SolubilityDMSO (30 mg/ml)
                  Storage -20°C
                  Protect from light
                  Do Not Freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
                  Toxicity Irritant
                  ReferencesYamada. T., et al. 2012. Free Radic. Biol. Med. (In press)
                  Powell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
                  Davies, S.P., et al. 2000. Biochem. J. 351, 95.
                  Iwasaki, S., et al. 1999. J. Biol. Chem. 274, 26503.
                  Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
                  LoGrasso, P.V., et al. 1997. Biochem. 36, 10422.
                  Hazzalin, C.A., et al. 1996. Curr. Biol. 6, 1028.
                  Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723.
                  Saklatvala, J., et al. 1996. J. Biol. Chem. 271, 6586.
                  Cuenda, A., et al. 1995. FEBS Lett. 364, 229.
                  Gallagher, T.F., et al. 1995. Bioorg. Med. Chem. Lett. 5, 1171.
                  Lee, J.C., et al. 1994. Nature 372, 739.
                  Citation
                • Yamada. T., et al. 2012. Free Radic. Biol. Med. (In press)
                • Satoshi Fukumoto, et al. (2006) Laminin 5 is required for dental epithelium growth and polarity and the development of tooth bud and shape. Journal of Biological Chemistry 281, 5008-5016.
                • Alexandra Thiel, et al. (2006) Expression of Cyclooxygenase-2 Is Regulated by Glycogen Synthase Kinase-3beta in Gastric Cancer Cells. Journal of Biological Chemistry 281, 4564-4569.
                • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.
                • Bysani Chandrasekar, et al. (2005) The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-J. Journal of Biological Chemistry 280, 26263-26277.
                • Guadalupe Sabio, et al. (2005) p38γ regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP. The EMBO Journal 24, 1134-1145.
                • Jose G. Trevino, et al. (2005) Expression and activity of Src regulate interleukin-8 expression in pancreatic adenocarcinoma cells: implications for angiogenesis. Cancer Research 65, 7214-7222.
                • Wojciech Wojciechowski, et al. (2005) Enhanced Expression of CD20 in Human Tumor B Cells is Controlled Through ERK-Dependent Mechanisms. Journal of Immunology 174, 7859-7868.
                • Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.
                • Naoto Inukai, et al. (2004) A novel hydrogen peroxide-induced phosphorylation and ubiquitination pathway leading to RNA polymerase II proteolysis. Journal of Biological Chemistry 279, 8190-8195.
                • Produits & Applications associés

                  Alternative Products

                  Référence Description  
                  559395 SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem Prix & Disponibilité

                  Related Products

                  Référence Description  
                  559388 SB 202190 - CAS 152121-30-7 - Calbiochem Prix & Disponibilité
                  559396 SB 220025 Prix & Disponibilité

                  Catégories

                  Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > MAP Kinase Inhibitors