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MABC200 | Anti-APC Antibody, clone CC-1

MABC200
100 µL  
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      Replacement Information

      Ofertas especiais

      Tabela com principais espec.

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H IHC M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABC200
      DescriptionAnti-APC Antibody, clone CC-1
      Alternate Names
      • Adenomatous polyposis coli protein
      • APC
      • Deleted in polyposis 2.5
      Background InformationAdenomatous polyposis coli protein (APC) is a ubiquitous multidomain protein that has a well documented role as a tumor suppressor. The mechanism of APC-mediated tumor suppression is still an area of active investigation; however, several studies suggest that APC is a negative regulator of the Wnt signaling pathway as it downregulates β-catenin via interactions with Axin/GSK3-β complex, thereby preventing transcription of genes such as MYC that contribute to cell proliferation. Defective APC proteins contribute to the initiation and proliferation of various types of cancers, including familial adenomatous polyposis. However, other studies have shown that APC interacts with a range of other proteins such as the EB1 microtubule-binding proteins, to regulate other processes such as cell migration.
      References
      Product Information
      FormatPurified
      Control
      • Human colon tissue
      PresentationPurified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-APC Antibody, clone CC-1 detects levels of APC proteins & has been published & validated for use in IHC.
      Key Applications
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A representative lot from an independent laboratory detected APC in human brain tissue containing multiple schlerosis lesions (Saikali, P. et al. (2007). J Neurosci. 27(5):1220-1228.).

      Immunohistochemistry Analysis: A representative lot from an independent laboratory detected APC in rat spinal cord injury tissue (McTique, D. M., et al. (2001). J Neurosci. 21(10):3392-3400.).
      Biological Information
      ImmunogenRecombinant protein corresponding to human APC.
      CloneCC-1
      HostMouse
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • APC
      • DP2.5
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight311 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceImmunohistochemistry Analysis: A 1:5 dilution from a representative lot detected APC in human colorectal cancer tissue, human smooth muscle tissue, and human colon tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Certificados de análise

      TítuloNúmero do lote
      Anti-APC, clone CC-1 2485969
      Anti-APC, clone CC-1 - 2391197 2391197
      Anti-APC, clone CC-1 - 2438663 2438663
      Anti-APC, clone CC-1 - 2363610 2363610
      Anti-APC, clone CC-1 - Q2009199 Q2009199
      Anti-APC, clone CC-1 -2514228 2514228
      Anti-APC, clone CC-1 -2585920 2585920
      Anti-APC, clone CC-1 -2620676 2620676
      Anti-APC, clone CC-1 -2642627 2642627
      Anti-APC, clone CC-1 -2706745 2706745
      Anti-APC, clone CC-1 -2745596 2745596
      Anti-APC, clone CC-1 -2778842 2778842

      Referências

      Visão geral das referênciasPub Med ID
      NKG2D-mediated cytotoxicity toward oligodendrocytes suggests a mechanism for tissue injury in multiple sclerosis.
      Saikali, Philippe, et al.
      J. Neurosci., 27: 1220-8 (2007) 2007

      Mostrar Resumo
      17267578 17267578
      Proliferation of NG2-positive cells and altered oligodendrocyte numbers in the contused rat spinal cord.
      McTigue, D M, et al.
      J. Neurosci., 21: 3392-400 (2001) 2001

      Mostrar Resumo
      11331369 11331369

      Brochura

      Título
      New Products: Volume 3, 2012