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AB1797P | Anti-Arginine Vasopressin Receptor V2 Antibody

AB1797P
50 µg  
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      Replacement Information

      Ofertas especiais

      Tabela com principais espec.

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R ELISA, IHC, WB Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberAB1797P
      ReplacesAB3512P
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Arginine Vasopressin Receptor V2 Antibody
      Alternate Names
      • AVPR-V2
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin. Liquid in PBS containing 0.1% BSA.
      Applications
      ApplicationAnti-Arginine Vasopressin Receptor V2 Antibody is an antibody against Arginine Vasopressin Receptor V2 for use in ELISA, IH & WB.
      Key Applications
      • ELISA
      • Immunohistochemistry
      • Western Blotting
      Application NotesWestern blot: 1-10 μg/mL using ECL. An antibody raised against this peptide has detected a glycosylated band at ~62 kDa in membranes from rat inner medulla (Nonoguchi et al. 1995). N-Glycanase reduced the size to ~36 kDa (deglycosylated form).

      Immunohistochemistry: 2-10 μg/mL on paraformaldehyde fixed tissue. AVP-V2 has been localized in terminal IMCD and other areas of rat kidney (Nonoguchi et al. 1995).

      ELISA: 0.5-1.0 μg/mL using 1 μg/mL of control peptide to coat plate.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      Immunogen21 amino acid peptide from the 3rd cytoplasmic domain of rat AVP-V2 (Lolait et al. 1992; Fisov et al. 1994).
      HostRabbit
      SpecificityArginine vasopressin receptor (AVP-V2), rat. The peptide used for immunization has no significant similarity with AVP V1a or V1b receptors.
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing.
      Gene Symbol
      • AVPR2
      • DI1
      • V2R
      • DIR
      • MGC138386
      • MGC126533
      • DIR3
      • ADHR
      • NDI
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P30518 # Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
      SIZE: 371 amino acids; 40279 Da
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Kidney.
      DISEASE: SwissProt: P30518 # Defects in AVPR2 are the cause of nephrogenic syndrome of inappropriate antidiuresis (NSIAD) [MIM:300539]. This disorder is characterized by an inability to excrete a free water load, with inappropriately concentrated urine and resultant hyponatremia, hypoosmolarity, and natriuresis. & Defects in AVPR2 are a cause of X-linked nephrogenic diabetes insipidus, type I (NDI) [MIM:304800]. It is characterized by excessive water drinking (polydypsia) and urine excretion (polyuria) and fail to concentrate urine in response to vasopressin. Most cases of NDI appear to have an X-linked recessive pattern of inheritance.
      SIMILARITY: SwissProt: P30518 ## Belongs to the G-protein coupled receptor 1 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to six months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Certificados de análise

      TítuloNúmero do lote
      RABBIT ANTI-ARGININE VASOPRESSIN RECEPTOR (AVPR-V2) AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2151809 2151809
      RABBIT ANTI-ARGININE VASOPRESSIN RECEPTOR (AVPR-V2) AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2446696 2446696
      RABBIT ANTI-ARGININE VASOPRESSIN RECEPTOR (AVPR-V2) -2529885 2529885
      RABBIT ANTI-ARGININE VASOPRESSIN RECEPTOR (AVPR-V2) -2601716 2601716
      RABBIT ANTI-ARGININE VASOPRESSIN RECEPTOR (AVPR-V2) -2689058 2689058
      RABBIT ANTI-ARGININE VASOPRESSIN RECEPTOR (AVPR-V2) -2695219 2695219
      RABBIT ANTI-ARGININE VASOPRESSIN RECEPTOR (AVPR-V2) -2762357 2762357
      RABBIT ANTI-ARGININE VASOPRESSIN RECEPTOR (AVPR-V2) -2822810 2822810
      RABBIT ANTI-ARGININE VASOPRESSIN RECEPTOR (AVPR-V2) AFFINITY PURIFIED POLYCLONAL ANTIBODY - 1995582 1995582

      Referências

      Visão geral das referênciasPub Med ID
      Increased water intake decreases progression of polycystic kidney disease in the PCK rat.
      Nagao, S; Nishii, K; Katsuyama, M; Kurahashi, H; Marunouchi, T; Takahashi, H; Wallace, DP
      Journal of the American Society of Nephrology : JASN 17 2220-7 2006

      Mostrar Resumo
      16807403 16807403
      Immunohistochemical localization of V2 vasopressin receptor along the nephron and functional role of luminal V2 receptor in terminal inner medullary collecting ducts.
      Nonoguchi, H, et al.
      J. Clin. Invest., 96: 1768-78 (1995) 1995

      Mostrar Resumo
      7560068 7560068
      Molecular analysis of vasopressin receptors in the rat nephron. Evidence for alternative splicing of the V2 receptor.
      Firsov, D, et al.
      Pflugers Arch., 429: 79-89 (1994) 1994

      Mostrar Resumo
      7708485 7708485

      Ficha de dados

      Título
      RABBIT ANTI-ARGININE VASOPRESSIN RECEPTOR (AVPR-V2) AFFINITY PURIFIED POLYCLONAL ANTIBODY