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AB2915 | Anti-Bax Antibody

AB2915
100 µL  
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      Replacement Information

      Ofertas especiais

      Tabela com principais espec.

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M WB, IH(P) Rb Serum Polyclonal Antibody
      Description
      Catalogue NumberAB2915
      Replaces04-434
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Bax Antibody
      References
      Product Information
      FormatSerum
      PresentationLiquid antiserum, no preservatives.
      Applications
      ApplicationThis Anti-Bax Antibody is validated for use in WB, IH(P) for the detection of Bax.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry (ABC method) on formalin-fixed paraffin-embedded sections (1:600-1:1500)

      Immunoblot (1;2500) using ECL detection.

      High levels of Bax-alpha are found in areas of the brain, including the cerebrum and cerebellum, as well as the small intestine, stomach, overy, testis, uterus, thymus, and spleen.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenA synthetic peptide corresponding to amino acids 43-61 of the mouse Bax-alpha protein.
      HostRabbit
      SpecificityRecognizes Mouse and Rat Bax-alpha, a 21 kDa protein, as well as a longer 24 kDa. Bax-beta isoform and a 5 kDa Bax-gamma isoform, which are present in much smaller amounts in most tissues. Does not react with other members of the Bcl-2 family, as verified by immunoblot.
      Species Reactivity
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
      Gene Symbol
      • BAX
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q07814 # Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor Bcl-2 or its adenovirus homolog E1B 19k protein.| Q07812 # Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Induces the release of cytochrome c, activation of CASP3, and thereby apoptosis.
      SIZE: 41 amino acids; 4678 Da
      SUBUNIT: Interacts with HN.
      SUBCELLULAR LOCATION: Cytoplasm.
      DOMAIN: SwissProt: Q07815
      DISEASE:SwissProt: Q07812 # Defects in BAX are found in some cell lines from hematopoietic malignancies as T-cell acute lymphoblastic leukemia, Burkitt lymphoma, and plasmacytoma.
      SIMILARITY: SwissProt: Q07815 ## Belongs to the Bcl-2 family. | Q07814 # Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.# Belongs to the Bcl-2 family. | P55269 ## Belongs to the Bcl-2 family. | Q07812 # Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family (By similarity).# Belongs to the Bcl-2 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20°C for up to 12 months in undiluted aliquots. Avoid repeated freeze-thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Certificados de análise

      TítuloNúmero do lote
      RABBIT ANTI-MOUSE BAX 2472889
      RABBIT ANTI-MOUSE BAX POLYCLONAL ANTIBODY - 2387390 2387390
      RABBIT ANTI-MOUSE BAX POLYCLONAL ANTIBODY - 2172661 2172661
      RABBIT ANTI-MOUSE BAX POLYCLONAL ANTIBODY - 2327983 2327983
      RABBIT ANTI-MOUSE BAX POLYCLONAL ANTIBODY -2492203 2492203

      Referências

      Visão geral das referênciasPub Med ID
      Core erythropoietin receptor signals for late erythroblast development.
      Menon, MP; Fang, J; Wojchowski, DM
      Blood 107 2662-72 2006

      Mostrar Resumo Texto completo do artigo
      16332976 16332976

      Ficha de dados

      Título
      Anti-Bax - Data Sheet

      Produtos e aplicações relacionadas

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      Categorias

      Life Science Research > Antibodies and Assays > Primary Antibodies