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AB1570 | Anti-GABA Transporter-1 Antibody, CT (a.a. 588-599)

AB1570
10 µg  
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      Replacement Information

      Ofertas especiais

      Tabela com principais espec.

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, Mk, R, Rb, Fe IHC Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberAB1570
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-GABA Transporter-1 Antibody, CT (a.a. 588-599)
      Alternate Names
      • GAT-1
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified antibody. Lyophilized from in 0.1 M PBS with 1% BSA and 0.1% sodium azide. Reconstitute with 100 μL of sterile distilled water.
      Applications
      ApplicationAnti-GABA Transporter-1 Antibody, C-terminus (a.a. 588-599) is an antibody against GABA Transporter-1 for use in IH.
      Key Applications
      • Immunohistochemistry
      Applications Not Recommended
      • Western Blotting
      Application NotesImmunohistochemistry: 1:500-1:750 on 4% paraformaldehyde fixed or 4% paraformaldehyde and 0.2% glutaraldehyde fixed tissue. It is recommended that the antibody be diluted in PBS containing 10% normal goat serum and 0.5% Triton X-100. AB1570 has been used for both light and electron microscopic studies of rat retina, cortex and hippocampus.

      Note: AB1570 is not recommended for Western blot use. See AB1570W.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenRat GAT-1, C-terminus (aa 588-599)
      EpitopeC-terminus (a.a. 588-599)
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityGABA Transporter-1 (GAT-1), C-terminus. No cross-reactivity to the C-termini of other transmitter transporters detected.
      Species Reactivity
      • Human
      • Mouse
      • Monkey
      • Rat
      • Rabbit
      • Feline
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SLC6A1
      • GABATR
      • GAT1
      • GABATHG
      • GABT1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P30531 # Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.
      SIZE: 599 amino acids; 67015 Da
      SUBUNIT: Interacts with MPP5 (By similarity).
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons (By similarity).
      DOMAIN: SwissProt: P30531 The PDZ domain-binding motif is involved in the interaction with MPP5.
      SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) family.
      MISCELLANEOUS: This protein is the target of psychomotor stimulants such as amphetamines or cocaine.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material at 2-8°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Certificados de análise

      TítuloNúmero do lote
      RABBIT ANTI-GABA TRANSPORTER-1 (GAT-1) -2659160 2659160
      RABBIT ANTI-GABA TRANSPORTER-1 (GAT-1) -2772708 2772708
      RABBIT ANTI-GABA TRANSPORTER-1 (GAT-1) POLYCLONAL ANTIBODY - 2290928 2290928
      RABBIT ANTI-GABA TRANSPORTER-1 (GAT-1) POLYCLONAL ANTIBODY -2506294 2506294

      Referências | 21 Disponível | Ver todas as referências

      Visão geral das referênciasAplicaçãoEspéciesPub Med ID
      Molecular identity of axonal sodium channels in human cortical pyramidal cells.
      Tian, C; Wang, K; Ke, W; Guo, H; Shu, Y
      Frontiers in cellular neuroscience 8 297 2014

      Mostrar Resumo
      25294986 25294986
      Distinct neurochemical and functional properties of GAD67-containing 5-HT neurons in the rat dorsal raphe nucleus.
      Shikanai, H; Yoshida, T; Konno, K; Yamasaki, M; Izumi, T; Ohmura, Y; Watanabe, M; Yoshioka, M
      The Journal of neuroscience : the official journal of the Society for Neuroscience 32 14415-26 2012

      Mostrar Resumo
      23055511 23055511
      Inhibition of Activity of GABA Transporter GAT1 by δ-Opioid Receptor.
      Pu, L; Xu, N; Xia, P; Gu, Q; Ren, S; Fucke, T; Pei, G; Schwarz, W
      Evidence-based complementary and alternative medicine : eCAM 2012 818451 2012

      Mostrar Resumo
      Western Blotting23365600 23365600
      The synaptic proteome during development and plasticity of the mouse visual cortex.
      Dahlhaus, M; Li, KW; van der Schors, RC; Saiepour, MH; van Nierop, P; Heimel, JA; Hermans, JM; Loos, M; Smit, AB; Levelt, CN
      Molecular & cellular proteomics : MCP 10 M110.005413 2011

      Mostrar Resumo Texto completo do artigo
      21398567 21398567
      Differential distribution of neurons in the gyral white matter of the human cerebral cortex.
      V García-Marín,L Blazquez-Llorca,J R Rodriguez,J Gonzalez-Soriano,J DeFelipe
      The Journal of comparative neurology 518 2010

      Mostrar Resumo
      20963826 20963826
      Localization and function of GABA transporters in the globus pallidus of parkinsonian monkeys.
      Adriana Galvan,Xing Hu,Yoland Smith,Thomas Wichmann
      Experimental neurology 223 2010

      Mostrar Resumo Texto completo do artigo
      20138865 20138865
      Pericellular innervation of neurons expressing abnormally hyperphosphorylated tau in the hippocampal formation of Alzheimer's disease patients.
      Blazquez-Llorca, L; Garcia-Marin, V; Defelipe, J
      Frontiers in neuroanatomy 4 20 2010

      Mostrar Resumo Texto completo do artigo
      20631843 20631843
      Glutamate uptake triggers transporter-mediated GABA release from astrocytes.
      Héja, L; Barabás, P; Nyitrai, G; Kékesi, KA; Lasztóczi, B; Toke, O; Tárkányi, G; Madsen, K; Schousboe, A; Dobolyi, A; Palkovits, M; Kardos, J
      PloS one 4 e7153 2009

      Mostrar Resumo Texto completo do artigo
      19777062 19777062
      A novel type of interplexiform amacrine cell in the mouse retina.
      Karin Dedek,Tobias Breuninger,Luis Pérez de Sevilla Müller,Stephan Maxeiner,Konrad Schultz,Ulrike Janssen-Bienhold,Klaus Willecke,Thomas Euler,Reto Weiler
      The European journal of neuroscience 30 2009

      Mostrar Resumo
      19614986 19614986
      An automated segmentation methodology for quantifying immunoreactive puncta number and fluorescence intensity in tissue sections.
      Fish, Kenneth N, et al.
      Brain Res., 1240: 62-72 (2008) 2008

      Mostrar Resumo
      Human18793619 18793619

      Ficha de dados

      Título
      RABBIT ANTI-GABA TRANSPORTER-1 (GAT-1)

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      Famílias de produtos

      Categorias

      Life Science Research > Antibodies and Assays > Primary Antibodies