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MAB4161 | Anti-MDR1 Antibody, extracellular human specific Pgp, clone MM12.10

MAB4161
100 µg  
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      Replacement Information

      Ofertas especiais

      Tabela com principais espec.

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H FC, IH(P) M Purified Monoclonal Antibody
      Description
      Catalogue NumberMAB4161
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-MDR1 Antibody, extracellular human specific Pgp, clone MM12.10
      Alternate Names
      • P-glycoprotein
      • CD243
      • p170
      • Pgp
      References
      Product Information
      FormatPurified
      PresentationPurified immunoglobulin from Protein A Sepharose™ chromatography. Liquid in 0.02M PB, pH 7.6, 0.25M NaCl containing 0.1% sodium azide.
      Applications
      ApplicationDetect MDR1 using this Anti-MDR1 Antibody, extracellular human specific Pgp, clone MM12.10 validated for use in FC, IH(P).
      Key Applications
      • Flow Cytometry
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry on formalin fixed paraffin embedded sections

      Confocal and Electron Microscopy

      ELISA

      Functional Studies (Cianfriglia, 2002)

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenLiving intact human multidrug-resistant cells
      Epitopeextracellular human specific Pgp
      CloneMM12.10
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityMDR-1 clone MM12.10 recognizes a mapped epitope in the extracellular Pgp domain and detects low-level Pgp expression in living (intact) human MDR cells (Cianfriglia, 2002). The epitope has been mapped to the single amino acid level using different techniques (Romagnoli, 1999).
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
      Gene Symbol
      • ABCB1
      • PGY1
      • MGC163296
      • GP170
      • ABC20
      • CD243
      • P-gp
      • MDR1
      • CLCS
      • EC 3.6.3.44
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P08183 # Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
      SIZE: 1280 amino acids; 141463 Da
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Expressed in liver, kidney, small intestine and brain.
      SIMILARITY: SwissProt: P08183 ## Belongs to the ABC transporter family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. & Contains 2 ABC transmembrane type-1 domains. & Contains 2 ABC transporter domains.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

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      Categorias

      Life Science Research > Antibodies and Assays > Primary Antibodies