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07-283 | Anti-Met Antibody

07-283
200 µg  
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      Replacement Information

      Ofertas especiais

      Tabela com principais espec.

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M IP, WB Rb Purified Polyclonal Antibody
      Description
      Catalogue Number07-283
      Replaces04-1051
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Met Antibody
      Alternate Names
      • c-Met
      • cmet
      • HGFR
      • RCCP2
      • met proto-oncogene (hepatocyte growth factor receptor)
      References
      Product Information
      FormatPurified
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, and 0.05%Sodium Azide.
      Applications
      ApplicationAnti-Met Antibody detects level of Met & has been published & validated for use in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      Immunogenpeptide corresponding to amino acids 1361-1379 (APYPSLLPSQDNIDGEGNT) of mouse c-Met
      HostRabbit
      SpecificityMet receptor precursor and the c-Met b chain
      IsotypeIgG
      Species Reactivity
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma.
      Gene Symbol
      • MET
      • AUTS9
      • c-Met
      • RCCP2
      • HGFR
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P08581 # Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity.
      SIZE: 1390 amino acids; 155527 Da
      SUBUNIT: Heterodimer formed of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1 and GRB2. Interacts with SPSB1, SPSB2 and SPSB4 (By similarity). Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      DISEASE: SwissProt: P08581 # Activation of MET after rearrangement with the TPR gene produces an oncogenic protein. & Defects in MET may be associated with gastric cancer. & Defects in MET are a cause of hepatocellular carcinoma (HCC) [MIM:114550]. & Defects in MET are a cause of hereditary papillary renal carcinoma (HPRC) [MIM:605074]; also known as papillary renal cell carcinoma 2 (RCCP2). HPRC is a form of inherited kidney cancer characterized by a predisposition to develop multiple, bilateral papillary renal tumors. The pattern of inheritance is consistent with autosomal dominant transmission with reduced penetrance. & Genetic variations in MET may be associated with susceptibility to autism type 1B (AUTS1B) [MIM:608636]. Autism is a neurodevelopmental disorder characterized by disturbance in language, perception and socialization. The disorder is classically defined by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypical, and ritualized patterns of interests and behavior.
      SIMILARITY: SwissProt: P08581 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. & Contains 3 IPT/TIG domains. & Contains 1 protein kinase domain. & Contains 1 Sema domain.
      Molecular Weight170 & 140kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on mouse liver membrane fractions
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Certificados de análise

      TítuloNúmero do lote
      Anti-Met (rabbit polyclonal IgG) - 2212019 2212019
      Anti-Met - 22164 22164
      Anti-Met - 27208 27208
      Anti-Met - 33422 33422
      Anti-Met - DAM1655264 DAM1655264
      Anti-Met - DAM1754438 DAM1754438
      Anti-Met - DAM1791350 DAM1791350
      Anti-Met - JBC1831404 JBC1831404
      Anti-Met - JBC1884539 JBC1884539
      Anti-Met -2577330 2577330
      Anti-Met -2825505 2825505

      Referências

      Visão geral das referênciasAplicaçãoPub Med ID
      Intact p53-dependent responses in miR-34-deficient mice.
      Concepcion, CP; Han, YC; Mu, P; Bonetti, C; Yao, E; D'Andrea, A; Vidigal, JA; Maughan, WP; Ogrodowski, P; Ventura, A
      PLoS genetics 8 e1002797 2012

      Mostrar Resumo
      22844244 22844244
      The angiotensin IV analog Nle-Tyr-Leu-psi-(CH2-NH2)3-4-His-Pro-Phe (norleual) can act as a hepatocyte growth factor/c-Met inhibitor.
      Yamamoto, BJ; Elias, PD; Masino, JA; Hudson, BD; McCoy, AT; Anderson, ZJ; Varnum, MD; Sardinia, MF; Wright, JW; Harding, JW
      The Journal of pharmacology and experimental therapeutics 333 161-73 2010

      Mostrar Resumo Texto completo do artigo
      20086056 20086056
      Dynamic gene and protein expression patterns of the autism-associated met receptor tyrosine kinase in the developing mouse forebrain.
      Matthew C Judson, Mica Y Bergman, Daniel B Campbell, Kathie L Eagleson, Pat Levitt, Matthew C Judson, Mica Y Bergman, Daniel B Campbell, Kathie L Eagleson, Pat Levitt, Matthew C Judson, Mica Y Bergman, Daniel B Campbell, Kathie L Eagleson, Pat Levitt, Matthew C Judson, Mica Y Bergman, Daniel B Campbell, Kathie L Eagleson, Pat Levitt
      The Journal of comparative neurology 513 511-31 2009

      Mostrar Resumo Texto completo do artigo
      19226509 19226509
      Epidermal growth factor receptor plays a significant role in hepatocyte growth factor mediated biological responses in mammary epithelial cells.
      Bonine-Summers, AR; Aakre, ME; Brown, KA; Arteaga, CL; Pietenpol, JA; Moses, HL; Cheng, N
      Cancer biology & therapy 6 561-70 2007

      Mostrar Resumo
      17495520 17495520
      Clonal identification and characterization of self-renewing pluripotent stem cells in the developing liver
      Suzuki, A., et al
      J Cell Biol, 156:173-84 (2002) 2002

      Flow Cytometry11781341 11781341
      Expression of hepatocyte growth factor/scatter factor and its receptor c-Met in brain tumors: evidence for a role in progression of astrocytic tumors (Review).
      Moriyama, T, et al.
      Int. J. Mol. Med., 3: 531-6 (1999) 1999

      Mostrar Resumo
      10202187 10202187
      The role of hepatocyte growth factor and its receptor c-Met in multiple myeloma and other blood malignancies.
      Børset, M, et al.
      Leuk. Lymphoma, 32: 249-56 (1999) 1999

      10037022 10037022
      Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase.
      Birchmeier, C and Gherardi, E
      Trends Cell Biol., 8: 404-10 (1998) 1998

      9789329 9789329

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      Categorias

      Life Science Research > Antibodies and Assays > Primary Antibodies