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MAB3136 | Anti-Na+/H+ Exchanger-3 Antibody, isoform NHE3, clone 4F5

MAB3136
100 µg  
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      Replacement Information

      Ofertas especiais

      Tabela com principais espec.

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R, Rb ICC, IH(P), IP, WB M Purified Monoclonal Antibody
      Description
      Catalogue NumberMAB3136
      ReplacesMAB3134
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Na+/H+ Exchanger-3 Antibody, isoform NHE3, clone 4F5
      Alternate Names
      • NHE3
      References
      Product Information
      FormatPurified
      PresentationLiquid in 0.02M Phosphate buffer, 0.25M NaCl with 0.1% sodium azide.
      Applications
      ApplicationAnti-Na+/H+ Exchanger-3 Antibody, isoform NHE3, clone 4F5 detects level of Na+/H+ Exchanger-3 & has been published & validated for use in IC, IH(P), IP & WB.
      Key Applications
      • Immunocytochemistry
      • Immunohistochemistry (Paraffin)
      • Immunoprecipitation
      • Western Blotting
      Application NotesImmunoblotting (rabbit 80 kDa and rat ~83 kDa)

      Immunohistochemistry (rat) on PLP or paraformaldehyde fixed tissue. Works on paraffin embedded tissue sections.

      Immunocytochemistry

      Immunoprecipitation (use non-ionic detergent)

      Optimal working dilutions must be determined by the user.
      Biological Information
      ImmunogenMaltose Binding Protein fusion protein containing C-terminal 131 amino acids of rabbit NHE3.
      Epitopeisoform NHE3
      Clone4F5
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityNa+/H+ exchanger, isoform NHE3.
      IsotypeIgG1
      Species Reactivity
      • Rat
      • Rabbit
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SLC9A3
      • NHE3
      • NHE-3
      • MGC126718
      • Na
      • MGC126720
      • +H
      UniProt Number
      UniProt SummaryFUNCTION: IInvolved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
      SIZE: 832 amino acids; 92,749 Da
      SUBUNIT: Binds SLC9A3R1 and SLC9A3R2. Interacts with SHANK2 (By similarity).
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      PTM: Phosphorylated by PKA, which inhibits activity (By similarity).
      SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 6 months.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Certificados de análise

      TítuloNúmero do lote
      Na+/H+ EXCHANGER ISOFORM NHE3 MONOCLONAL ANTIBODY - 2384722 2384722
      Na+/H+ EXCHANGER -2552284 2552284
      Na+/H+ EXCHANGER -2610980 2610980
      Na+/H+ EXCHANGER -2691338 2691338
      Na+/H+ EXCHANGER -2730887 2730887
      Na+/H+ EXCHANGER -2745642 2745642
      Na+/H+ EXCHANGER ISOFORM NHE3 MONOCLONAL ANTIBODY - 2072902 2072902
      Na+/H+ EXCHANGER ISOFORM NHE3 MONOCLONAL ANTIBODY - 2187358 2187358
      Na+/H+ EXCHANGER ISOFORM NHE3 MONOCLONAL ANTIBODY - 2211032 2211032
      Na+/H+ EXCHANGER ISOFORM NHE3 MONOCLONAL ANTIBODY - 2504822 2504822

      Referências

      Visão geral das referênciasAplicaçãoPub Med ID
      Lactobacillus acidophilus upregulates intestinal NHE3 expression and function.
      Singh, V; Raheja, G; Borthakur, A; Kumar, A; Gill, RK; Alakkam, A; Malakooti, J; Dudeja, PK
      American journal of physiology. Gastrointestinal and liver physiology 303 G1393-401 2012

      Mostrar Resumo
      23086913 23086913
      Novel signaling mechanisms of intracellular angiotensin II-induced NHE3 expression and activation in mouse proximal tubule cells.
      Li, XC; Hopfer, U; Zhuo, JL
      American journal of physiology. Renal physiology 303 F1617-28 2012

      Mostrar Resumo
      23034941 23034941
      Angiotensin II-mediated biphasic regulation of proximal tubular Na+/H+ exchanger 3 is impaired during oxidative stress.
      Banday, AA; Lokhandwala, MF
      American journal of physiology. Renal physiology 301 F364-70 2011

      Mostrar Resumo
      Western Blotting21593187 21593187
      Elevated BSC-1 and ROMK expression in Dahl salt-sensitive rat kidneys.
      Hoagland, KM; Flasch, AK; Dahly-Vernon, AJ; dos Santos, EA; Knepper, MA; Roman, RJ
      Hypertension 43 860-5 2004

      Mostrar Resumo
      14967839 14967839
      Distribution of pH regulators in the rat laryngeal nerve: the spatial relationship between Na(+)/HCO(3)(-) cotransporters and Na(+)/H(+) exchanger type 3.
      Yoshio Yamamoto, Kazuyuki Taniguchi
      Neuroscience letters 368 127-9 2004

      Mostrar Resumo
      15351433 15351433
      Inhibition of the formation of EETs and 20-HETE with 1-aminobenzotriazole attenuates pressure natriuresis.
      Dos Santos, EA; Dahly-Vernon, AJ; Hoagland, KM; Roman, RJ
      American journal of physiology. Regulatory, integrative and comparative physiology 287 R58-68 2004

      Mostrar Resumo
      15031141 15031141
      Expression and localization of the Na+/H+ exchanger isoform NHE3 in the rat efferent ducts.
      Kari M Kaunisto, Hannu J Rajaniemi
      Journal of andrology 23 237-41 2002

      Mostrar Resumo
      11868817 11868817
      Immunolocalization of NBC3 and NHE3 in the rat epididymis: colocalization of NBC3 and the vacuolar H+-ATPase.
      A Pushkin, I Clark, T H Kwon, S Nielsen, I Kurtz, A Pushkin, I Clark, T H Kwon, S Nielsen, I Kurtz
      Journal of andrology 21 708-20 1997

      Mostrar Resumo
      10975418 10975418
      Monoclonal antibodies for high-resolution localization of NHE3 in adult and neonatal rat kidney.
      Biemesderfer, D, et al.
      Am. J. Physiol., 273: F289-99 (1997) 1997

      9277590 9277590

      Ficha de dados

      Título
      Anti-Na+/H+ Exchanger-3, isoform NHE3, clone 4F5 - Data Sheet