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AB5407 | Anti-Opsin Antibody, blue

AB5407
100 µg  
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      Replacement Information

      Ofertas especiais

      Tabela com principais espec.

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, Mk IH(P) Rb Purified Polyclonal Antibody
      Description
      Catalogue NumberAB5407
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Opsin Antibody, blue
      Background InformationThe full range of color discrimination in humans is based on the presence and function of three cone photoreceptor mechanisms. Each cone type possesses a photo-sensitive pigment-protein complex consisting of 11-cis retinal and a unique opsin protein, which gives sensitivity in the short (S cone, peak sensitivity about 420nm), middle (M cone, peak sensitivity about 530nm with polymorphism; Winderckx et al., 1993; Neitz & Neitz, 1998), and long (L cone, peak sensitivity about 560nm with polymorphism; Neitz & Jacobs, 1990) wavelengths of the light spectrum. All three opsins are transmembrane proteins with seven membrane-spanning regions. Genes for the three types of cone opsins and the rod photoreceptor rhodopsin gene seem to be homologous with varying amounts of conservation. Strongest conservation is between the middle (green) and long (red) wavelength sensitive pigments on the X chromosome, suggesting a relatively recent duplication/divergence event (Nathans, 1989; Nathans et al., 1992). The S cone (blue) opsin is located on chromosome 7 and seems to have stronger conservation with rhodopsin. Cone photoreceptor distribution in humans is dominated by the M and L cone pigments.
      References
      Product Information
      FormatPurified
      Control
      • Retina
      PresentationPurified immunoglobulinin PBS {0.02M phosphate, 0.25M NaCl, pH 7.6} with 0.1% sodium azide as a preservative
      Applications
      ApplicationThis Anti-Opsin Antibody, blue is validated for use in IH(P) for the detection of Opsin.
      Key Applications
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry: 1:200-1:300 on formalin-fixed, paraffin-embedded mouse retina tissue. Antigen retrieval method recommend is HIER with steam heat; other fixation and retrieval methods are untested.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenRecombinant human blue opsin.
      Epitopeblue
      HostRabbit
      SpecificityRecognizes Opsin, blue.
      Species Reactivity
      • Human
      • Mouse
      • Monkey
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • OPN1SW
      • CBT
      • BOP
      • BCP
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P03999 # Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.
      SIZE: 348 amino acids; 39135 Da
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: The three color pigments are found in the cone photoreceptor cells.
      PTM: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
      DISEASE:SwissProt: P03999 # Defects in OPN1SW are the cause of tritan color blindness (tritanopia) [MIM:190900].SIMILARITY:SwissProt: P03999 ## Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 1 year at 2–8°C from date of shipment.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Certificados de análise

      TítuloNúmero do lote
      RABBIT ANTI-OPSIN, BLUE POLYCLONAL ANTIBODY - 2424750 2424750
      RABBIT ANTI-OPSIN, BLUE POLYCLONAL ANTIBODY - 2462859 2462859
      RABBIT ANTI-OPSIN, BLUE POLYCLONAL ANTIBODY - 2011455 2011455
      RABBIT ANTI-OPSIN, BLUE -2605391 2605391
      RABBIT ANTI-OPSIN, BLUE -2712503 2712503
      RABBIT ANTI-OPSIN, BLUE -2775512 2775512
      RABBIT ANTI-OPSIN, BLUE -2819570 2819570
      RABBIT ANTI-OPSIN, BLUE POLYCLONAL ANTIBODY - 1993772 1993772
      RABBIT ANTI-OPSIN, BLUE POLYCLONAL ANTIBODY - 2043899 2043899
      RABBIT ANTI-OPSIN, BLUE POLYCLONAL ANTIBODY - 2201452 2201452
      RABBIT ANTI-OPSIN, BLUE POLYCLONAL ANTIBODY - 2287718 2287718
      RABBIT ANTI-OPSIN, BLUE POLYCLONAL ANTIBODY - 2363004 2363004
      RABBIT ANTI-OPSIN, BLUE POLYCLONAL ANTIBODY - 2554906 2554906

      Referências | 51 Disponível | Ver todas as referências

      Visão geral das referênciasAplicaçãoEspéciesPub Med ID
      AAV-mediated RLBP1 gene therapy improves the rate of dark adaptation in Rlbp1 knockout mice.
      Choi, VW; Bigelow, CE; McGee, TL; Gujar, AN; Li, H; Hanks, SM; Vrouvlianis, J; Maker, M; Leehy, B; Zhang, Y; Aranda, J; Bounoutas, G; Demirs, JT; Yang, J; Ornberg, R; Wang, Y; Martin, W; Stout, KR; Argentieri, G; Grosenstein, P; Diaz, D; Turner, O; Jaffee, BD; Police, SR; Dryja, TP
      Molecular therapy. Methods & clinical development 2 15022 2015

      Mostrar Resumo
      26199951 26199951
      Gene Therapy Fully Restores Vision to the All-Cone Nrl(-/-) Gucy2e(-/-) Mouse Model of Leber Congenital Amaurosis-1.
      Boye, SL; Peterson, JJ; Choudhury, S; Min, SH; Ruan, Q; McCullough, KT; Zhang, Z; Olshevskaya, EV; Peshenko, IV; Hauswirth, WW; Ding, XQ; Dizhoor, AM; Boye, SE
      Human gene therapy 26 575-92 2015

      Mostrar Resumo
      26247368 26247368
      CRALBP supports the mammalian retinal visual cycle and cone vision.
      Xue, Y; Shen, SQ; Jui, J; Rupp, AC; Byrne, LC; Hattar, S; Flannery, JG; Corbo, JC; Kefalov, VJ
      The Journal of clinical investigation 125 727-38 2015

      Mostrar Resumo
      25607845 25607845
      Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia.
      Kohl, S; Zobor, D; Chiang, WC; Weisschuh, N; Staller, J; Gonzalez Menendez, I; Chang, S; Beck, SC; Garcia Garrido, M; Sothilingam, V; Seeliger, MW; Stanzial, F; Benedicenti, F; Inzana, F; Héon, E; Vincent, A; Beis, J; Strom, TM; Rudolph, G; Roosing, S; Hollander, AI; Cremers, FP; Lopez, I; Ren, H; Moore, AT; Webster, AR; Michaelides, M; Koenekoop, RK; Zrenner, E; Kaufman, RJ; Tsang, SH; Wissinger, B; Lin, JH
      Nature genetics 47 757-65 2015

      Mostrar Resumo
      Western Blotting26029869 26029869
      Localization of complement factor H gene expression and protein distribution in the mouse outer retina.
      Smit-McBride, Z; Oltjen, SL; Radu, RA; Estep, J; Nguyen, AT; Gong, Q; Hjelmeland, LM
      Molecular vision 21 110-23 2015

      Mostrar Resumo
      25684976 25684976
      Long-term retinal cone survival and delayed alteration of the cone mosaic in a transgenic mouse model of stargardt-like dystrophy (STGD3).
      Kuny, S; Filion, MA; Suh, M; Gaillard, F; Sauvé, Y
      Investigative ophthalmology & visual science 55 424-39 2014

      Mostrar Resumo
      24334447 24334447
      Independent genomic control of neuronal number across retinal cell types.
      Keeley, PW; Whitney, IE; Madsen, NR; St John, AJ; Borhanian, S; Leong, SA; Williams, RW; Reese, BE
      Developmental cell 30 103-9 2014

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      24954025 24954025
      Three distinct blue-green color pathways in a mammalian retina.
      Mills, SL; Tian, LM; Hoshi, H; Whitaker, CM; Massey, SC
      The Journal of neuroscience : the official journal of the Society for Neuroscience 34 1760-8 2014

      Mostrar Resumo
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      Natural history of cone disease in the murine model of Leber congenital amaurosis due to CEP290 mutation: determining the timing and expectation of therapy.
      Boye, SE; Huang, WC; Roman, AJ; Sumaroka, A; Boye, SL; Ryals, RC; Olivares, MB; Ruan, Q; Tucker, BA; Stone, EM; Swaroop, A; Cideciyan, AV; Hauswirth, WW; Jacobson, SG
      PloS one 9 e92928 2014

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      Onecut1 and Onecut2 redundantly regulate early retinal cell fates during development.
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      Proceedings of the National Academy of Sciences of the United States of America 111 E4086-95 2014

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      Ficha de dados

      Título
      Anti-Opsin, blue - Data Sheet