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MABF81 | Anti-ROR gamma T Antibody, clone 6F3.1

MABF81
100 µg  
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      Replacement Information

      Ofertas especiais

      Tabela com principais espec.

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, IHC M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABF81
      DescriptionAnti-ROR gamma T Antibody, clone 6F3.1
      Alternate Names
      • Nuclear receptor ROR-gamma
      • Nuclear receptor RZR-gamma
      • Nuclear receptor subfamily 1 group F member 3
      • Retinoid-related orphan receptor-gamma
      Background InformationRetinoid-related orphan receptor-gamma t (RORγT) is one of two RORγ isoforms belonging to the nuclear hormone receptor family and contains a single nuclear receptor DNA-binding domain. RORγT is a negative regulator of TNFDF6/FASL expression and T-cell production of IL2. The upregulation of RORγT is a requirement for TH17 cell differentiation. Inhibition of RORγT is induced by TGF-β’s interaction with Foxp3. Expression is observed mainly in immature thymocytes, and, during fetal development, is found exclusively in lymphoid-inducer (LTi) cells.
      References
      Product Information
      FormatPurified
      Control
      • T47D cell lysate
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationThis Anti-ROR gamma T Antibody, clone 6F3.1 is validated for use in WB, IH for the detection of ROR gamma T.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution of this antibody detected ROR gamma T in normal human liver tissues.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human ROR gamma T.
      Clone6F3.1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene.
      Gene Symbol
      • RORC
      • NR1F3
      • RORG
      • RZRG
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4+ T helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.

      SUBCELLULAR LOCATION: Nucleus.

      TISSUE SPECIFICITY: Isoform 1: widely expressed in many tissues, including liver and adipose, and highly expressed in skeletal muscle. Isoform 2: Primarily expressed in immature thymocytes.
      Molecular Weight~55 kDa observed. Two isoforms at ~55 kDa and ~58 kDa may be observed in some cell lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluted in Western Blot in T47D cell lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected ROR gamma T in 10 µg of T47D cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Certificados de análise

      TítuloNúmero do lote
      Anti-ROR gamma T, clone 6F3.1 - 2385997 2385997
      Anti-ROR gamma T, clone 6F3.1 - 2051970 2051970
      Anti-ROR gamma T, clone 6F3.1 - 2146026 2146026
      Anti-ROR gamma T, clone 6F3.1 - 2193603 2193603
      Anti-ROR gamma T, clone 6F3.1 - 2196094 2196094
      Anti-ROR gamma T, clone 6F3.1 - 2203082 2203082
      Anti-ROR gamma T, clone 6F3.1 - 2219382 2219382
      Anti-ROR gamma T, clone 6F3.1 - 2270332 2270332
      Anti-ROR gamma T, clone 6F3.1 - 2282196 2282196
      Anti-ROR gamma T, clone 6F3.1 - 2297276 2297276
      Anti-ROR gamma T, clone 6F3.1 - 2343144 2343144
      Anti-ROR gamma T, clone 6F3.1 - Q1970786 Q1970786
      Anti-ROR gamma T, clone 6F3.1 -2504315 2504315
      Anti-ROR gamma T, clone 6F3.1 -2586548 2586548
      Anti-ROR gamma T, clone 6F3.1 -2645428 2645428
      Anti-ROR gamma T, clone 6F3.1 -2668549 2668549
      Anti-ROR gamma T, clone 6F3.1 -2698523 2698523
      Anti-ROR gamma T, clone 6F3.1 -2714101 2714101
      Anti-ROR gamma T, clone 6F3.1 -2718247 2718247
      Anti-ROR gamma T, clone 6F3.1 -2775359 2775359
      Anti-ROR gamma T, clone 6F3.1 -2786076 2786076