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AB3042 | Anti-Uncoupling Protein 2 Antibody

AB3042
50 µg  
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      Replacement Information

      Ofertas especiais

      Tabela com principais espec.

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M ELISA, WB Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberAB3042
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Uncoupling Protein 2 Antibody
      Alternate Names
      • UCP2
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin. Liquid in PBS with 0.1% BSA .
      Applications
      ApplicationThis Anti-Uncoupling Protein 2 Antibody is validated for use in ELISA, WB for the detection of Uncoupling Protein 2.
      Key Applications
      • ELISA
      • Western Blotting
      Application NotesWestern Blotting: 1-10 μg/mL using Chemiluminescence technique.

      ELISA: 1:10,000-1:100,000; using 50-100 ng UCP2 control peptide/well.

      Optimal working dilutions must be determined by end user.
      Biological Information
      Immunogen14 aa peptide sequence at the C-terminus of the mouse UCP2 (Fleury et al. 1997). The peptide has no significant homology with UCP1.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityUncoupling Protein 2 (UCP2), mouse. Mouse UCP2 is a 309 amino acid mitochondrial uncoupling protein (Fleury et al. 1997). It is only 59% homologous with UCP1 found in brown adipose tissues. Mouse UCP2 (chromosome 7) has approximately 95% homology with human UCP2 located on chromosome 11 (Fleury et al. 1997). UCP2 has wide tissue distribution in mouse tissues (brain, kidney, liver, brown adipose tissue, heart, and muscle). UCP2 may play a critical role in energy balance, body weight, and thermoregulation (Fleury et al. 1997; Flier & Lowell 1997).

      SPECIES REACTIVITIES: The antibody has not yet been tested for cross-reactivity to other species. The sequence used for immunization shows 92% homology to rat and 86% homology to human UCP2.
      Species Reactivity
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryMitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'.
      Gene Symbol
      • UCP2
      • UCPH
      • SLC25A8
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P55851 # UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.
      SIZE: 309 amino acids; 33229 Da
      SUBUNIT: Acts as a dimer forming a proton channel (By similarity).
      SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Widely expressed in adult human tissues, including tissues rich in macrophages. Most expressed in white adipose tissue and skeletal muscle.
      SIMILARITY: SwissProt: P55851 ## Belongs to the mitochondrial carrier family. & Contains 3 Solcar repeats.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Certificados de análise

      TítuloNúmero do lote
      RABBIT ANTI-MOUSE UNCOUPLING PROTEIN 2 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2055978 2055978

      Referências

      Visão geral das referênciasPub Med ID
      Targeting deficiencies in mitochondrial respiratory complex I and functional uncoupling exerts anti-seizure effects in a genetic model of temporal lobe epilepsy and in a model of acute temporal lobe seizures.
      Simeone, KA; Matthews, SA; Samson, KK; Simeone, TA
      Experimental neurology 251 84-90 2014

      Mostrar Resumo
      24270080 24270080

      Ficha de dados

      Título
      RABBIT ANTI-MOUSE UNCOUPLING PROTEIN 2 AFFINITY PURIFIED POLYCLONAL ANTIBODY

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      Categorias

      Life Science Research > Antibodies and Assays > Primary Antibodies