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567616 | Sodium 4-Phenylbutyrate - CAS 1716-12-7 - Calbiochem

567616
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      Panorama geral

      Replacement Information

      Tabela com principais espec.

      Empirical FormulaCAS #
      C₁₀H₁₁O₂Na 1716-12-7

      Preço e Disponibilidade

      Número de catálogoDisponibilidade Embalagem Qtde/Emb. Preço Quantidade
      US1567616-100MG
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          Frasco de vidro 100 mg
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          Description
          OverviewA novel anti-neoplastic agent and transcriptional regulator. Also acts as an inducer of tumor cytostasis and differentiation. Increases fetal hemoglobin production in vitro and in vivo.
          Catalogue Number567616
          Brand Family Calbiochem®
          SynonymsSPB, PBNa, 4PBA, 4-Phenylbutyrate, Na, BDK Inhibitor I, BCKD Kinase Inhibitor I, Branched-Chain α-Ketoacid Dehydrogenase Kinase Inhibitor I
          References
          ReferencesTso, S.C., et al. 2013. Proc. Natl. Acad. Sci. USA 110, 9728.
          Ozcan, U., et al. 2006. Science 313, 1137.
          Carducci, M.A., et al. 2001. Clin. Cancer Res. 7, 3047.
          Rubenstein, R.C. and Zeitlin, P.L. 2000. Am.J. Physiol. Cell. Physiol. 278, C259.
          Lea, M.A., et al. 1999. Anticancer Res. 19, 1971.
          Miller, A.C., et al. 1997. Int. J. Radiat. Biol. 72, 211.
          Rubenstein, R.C., et al. 1997. J. Clin. Invest. 100, 2457.
          Pineau, T., et al. 1996. Biochem. Pharmacol. 52, 659.
          Collins, A.F., et al. 1995. Blood 85, 43.
          Lea, M.A., et al. 1995. Anticancer Res. 15, 879.
          Figg, W.D., et al. 1994. Anticancer Drugs 5, 336.
          Liu, L., et al. 1994. J. Invest. Dermatol. 103, 335.
          Product Information
          CAS number1716-12-7
          ATP CompetitiveN
          FormWhite to slightly yellow solid
          Hill FormulaC₁₀H₁₁O₂Na
          Chemical formulaC₁₀H₁₁O₂Na
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula Image
          Applications
          ApplicationSodium 4-Phenylbutyrate, CAS 1716-12-7, is a novel anti-neoplastic agent and transcriptional regulator. Also acts as an inducer of tumor cytostasis and differentiation.
          Biological Information
          Primary TargetAnti-neoplastic agent
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          MSDS

          Título

          Ficha de Segurança de Produtos (MSDS) 

          Certificados de análise

          TítuloNúmero do lote
          567616

          Referências

          Visão geral de referência
          Tso, S.C., et al. 2013. Proc. Natl. Acad. Sci. USA 110, 9728.
          Ozcan, U., et al. 2006. Science 313, 1137.
          Carducci, M.A., et al. 2001. Clin. Cancer Res. 7, 3047.
          Rubenstein, R.C. and Zeitlin, P.L. 2000. Am.J. Physiol. Cell. Physiol. 278, C259.
          Lea, M.A., et al. 1999. Anticancer Res. 19, 1971.
          Miller, A.C., et al. 1997. Int. J. Radiat. Biol. 72, 211.
          Rubenstein, R.C., et al. 1997. J. Clin. Invest. 100, 2457.
          Pineau, T., et al. 1996. Biochem. Pharmacol. 52, 659.
          Collins, A.F., et al. 1995. Blood 85, 43.
          Lea, M.A., et al. 1995. Anticancer Res. 15, 879.
          Figg, W.D., et al. 1994. Anticancer Drugs 5, 336.
          Liu, L., et al. 1994. J. Invest. Dermatol. 103, 335.
          Ficha de dados

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-May-2008 RFH
          SynonymsSPB, PBNa, 4PBA, 4-Phenylbutyrate, Na, BDK Inhibitor I, BCKD Kinase Inhibitor I, Branched-Chain α-Ketoacid Dehydrogenase Kinase Inhibitor I
          DescriptionAn antineoplastic agent that demonstrates potent differentiating capacity in multiple hematopoietic and solid tumor cell lines. Acts as an inducer of tumor cytostasis and differentiation as well as of peroxisomal proliferation. A more effective inhibitor of histone deacetylase and inducer of histone acetylation than its structural analogs including 2- and 3-phenylbutyrate. Acts as a transcriptional regulator and improve the targeting of δF508-CFTR (cystic fibrosis transmembrane regulator) for ubiquitination and degradation by reducing the expression of HSC70 in epithelial cells. Also, reported to increase fetal hemoglobin production in vitro and in vivo.
          FormWhite to slightly yellow solid
          CAS number1716-12-7
          Chemical formulaC₁₀H₁₁O₂Na
          Structure formula
          Purity≥98% by HPLC
          SolubilityH₂O (10 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesTso, S.C., et al. 2013. Proc. Natl. Acad. Sci. USA 110, 9728.
          Ozcan, U., et al. 2006. Science 313, 1137.
          Carducci, M.A., et al. 2001. Clin. Cancer Res. 7, 3047.
          Rubenstein, R.C. and Zeitlin, P.L. 2000. Am.J. Physiol. Cell. Physiol. 278, C259.
          Lea, M.A., et al. 1999. Anticancer Res. 19, 1971.
          Miller, A.C., et al. 1997. Int. J. Radiat. Biol. 72, 211.
          Rubenstein, R.C., et al. 1997. J. Clin. Invest. 100, 2457.
          Pineau, T., et al. 1996. Biochem. Pharmacol. 52, 659.
          Collins, A.F., et al. 1995. Blood 85, 43.
          Lea, M.A., et al. 1995. Anticancer Res. 15, 879.
          Figg, W.D., et al. 1994. Anticancer Drugs 5, 336.
          Liu, L., et al. 1994. J. Invest. Dermatol. 103, 335.