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12-338 | Wortmannin, (PI3 Kinase inhibitor)

12-338
1 mg  
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      Replacement Information
      Description
      Catalogue Number12-338
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionWortmannin, (PI3 Kinase inhibitor)
      OverviewWortmannin, a fungal metabolite, is a cell-permeable, irreversible inhibitor of phosphatidylinositol 3 kinase (PI3 Kinase) with an IC50 of 5nM. It blocks the catalytic activity of PI3-Kinase without affecting upstream signaling events such as insulin receptor tyrosine kinase activity. Wortmannin also inhibits the activities of myosin light chain kinase and PI4-Kinase at concentrations a hundred times higher than those required to inhibit PI3-Kinase.
      References
      Product Information
      Presentation1mg of lyophilized powder packaged under inert gas. White to off-white powder.
      Applications
      ApplicationThe Wortmannin, (PI3 Kinase inhibitor) controls the biological activity of PI3 Kinase. This small molecule/inhibitor is primarily used for Biochemicals applications.
      Key Applications
      • Kinase Assay
      Biological Information
      Entrez Gene Number
      Entrez Gene SummaryReceptor-regulated class I phosphoinositide 3-kinases (PI3Ks) phosphorylate the membrane lipid phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to PtdIns(3,4,5)P3, which in turn recruits and activates cytosolic effectors involved in proliferation, survival, or chemotaxis. PIK3R5 is a PI3K regulatory subunit (Brock et al., 2003 [PubMed 12507995]).[supplied by OMIM]
      Gene Symbol
      • PIK3R5
      • P101-PI3K
      • FOAP-2
      • F730038I15Rik
      Protein TargetPI3Kγ
      Target Sub-FamilyPI3K/PI4K
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q8WYR1 # Regulatory subunit of the PI3K gamma complex.
      SIZE: 880 amino acids; 97348 Da
      SUBUNIT: Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit. Interacts with G beta gamma proteins.
      SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity).
      TISSUE SPECIFICITY: Highly expressed in leukocytes, followed by spleen, lymph node, thymus ans bone marrow.
      DOMAIN:SwissProt: Q8WYR1 The heterodimerization region allows the binding to the catalytic subunit.
      SIMILARITY:
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by kinase assay.
      Purity: ≥95% by HPLC.
      Molecular Formula: C23H24O8
      Molecular Weight: 428.4
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsProtect from light. Stable for 2 years as supplied at -20°C. Following reconstitution aliquot and store at -20°. The DMSO/ethanol stock solutions are stable for 1-3 months at -20°C.
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Certificados de análise

      TítuloNúmero do lote
      Wortmannin (PI3 Kinase inhibitor) - 2153577 2153577
      Wortmannin (PI3 Kinase inhibitor) - 2375500 2375500
      Wortmannin (PI3 Kinase inhibitor) 2475643
      Wortmannin (PI3 Kinase inhibitor) - 2202511 2202511
      Wortmannin (PI3 Kinase inhibitor) - 2290358 2290358
      Wortmannin (PI3 Kinase inhibitor) - 2558391 2558391
      Wortmannin (PI3 Kinase inhibitor) - DAM1457516 DAM1457516
      Wortmannin (PI3 Kinase inhibitor) - DAM1467548 DAM1467548
      Wortmannin - 2519320 2519320
      Wortmannin - DAM1564577 DAM1564577
      Wortmannin - DAM1601846 DAM1601846
      Wortmannin - DAM1621680 DAM1621680
      Wortmannin - DAM1791363 DAM1791363
      Wortmannin - JBC1870084 JBC1870084
      Wortmannin -2618492 2618492
      Wortmannin -2620622 2620622
      Wortmannin -2728409 2728409
      Wortmannin -2772750 2772750
      Wortmannin, (PI3 Kinase inhibitor) - 15970 15970
      Wortmannin, (PI3 Kinase inhibitor) - 17897 17897
      Wortmannin, (PI3 Kinase inhibitor) - 19869 19869
      Wortmannin, (PI3 Kinase inhibitor) - 21377 21377
      Wortmannin, (PI3 Kinase inhibitor) - 23100 23100
      Wortmannin, (PI3 Kinase inhibitor) - 24071 24071
      Wortmannin, (PI3 Kinase inhibitor) - 28774 28774
      Wortmannin, (PI3 Kinase inhibitor) - 31729 31729
      Wortmannin, (PI3 Kinase inhibitor) - 33516 33516

      Referências

      Visão geral das referênciasAplicaçãoPub Med ID
      Akt/protein kinase B isoforms are differentially regulated by epidermal growth factor stimulation
      Okano, J., et al
      J Biol Chem, 275:30934-42 (2000) 2000

      Immunoblotting (Western)10908564 10908564
      Wortmannin and its structural analogue demethoxyviridin inhibit stimulated phospholipase A2 activity in Swiss 3T3 cells. Wortmannin is not a specific inhibitor of phosphatidylinositol 3-kinase.
      Cross, M J, et al.
      J. Biol. Chem., 270: 25352-5 (1995) 1995

      Mostrar Resumo
      7592698 7592698
      Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase.
      Ui, M, et al.
      Trends Biochem. Sci., 20: 303-7 (1995) 1995

      Mostrar Resumo
      7667888 7667888
      Wortmannin, a specific inhibitor of phosphatidylinositol-3 kinase, blocks osteoclastic bone resorption.
      Nakamura, I, et al.
      FEBS Lett., 361: 79-84 (1995) 1995

      Mostrar Resumo
      7890044 7890044
      Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin
      Okada, T, et al
      J Biol Chem, 269:3568-73 (1994) 1994

      8106400 8106400
      Platelet-derived growth factor-induced phosphatidylinositol 3-kinase activation mediates actin rearrangements in fibroblasts.
      Wymann, M and Arcaro, A
      Biochem. J., 298 Pt 3: 517-20 (1994) 1994

      Mostrar Resumo
      8141762 8141762
      Wortmannin inhibits mitogen-activated protein kinase activation induced by platelet-activating factor in guinea pig neutrophils.
      Ferby, I M, et al.
      J. Biol. Chem., 269: 30485-8 (1994) 1994

      Mostrar Resumo
      7982965 7982965

      Informações técnicas

      Título
      Unlocking the Mystery of Cancer: Do the Mutant p110α Subunits of PI3-Kinase Hold the Key?

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      Categorias

      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Kinase & Phosphatase Substrates
      Life Science Research > Proteins and Enzymes > Substrate & Control Proteins > Kinase & Phosphatase Substrates