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Stay up to date in analytical chromatography with Merck. Our brochures and guides offer valuable information about techniques and products that can support and optimize your investigations. Simply download your preferred literature from the list below, and remember to check back regularly for new publications.

HPLC Troubleshooting Guide

Untangle Your Liquid Chromatography Problems
HPLC Troubleshooting Guide
HPLC Troubleshooting Guide Our new, easy to use HPLC Troubleshooting Guide is organized into chapters covering the most common problems encountered in liquid chromatography.
  • Retention
  • Equilibration
  • Peaks
  • Recovery
  • Leaks
  • Selectivity
  • Baseline
  • Pressure

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Overview Catalog

ChromBook
The world of chromatography in your hands
ChromBook
  • In depth information covering Merck's chromatography products
  • Information about water purification systems and sample preparation
  • Method development support and applications, particulary for meeting pharmacopoeia requirements
  • Column selection guide and troubleshooting advice


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TLC/HPTLC Brochure

Fast and Precise
Thin Layer Chromatography by Merck
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Technique: Thin Layer Chromatography
Product(s): TLC and HPTLC product range

  • Complete portfolio of TLC, HPTLC, and PLC plates
  • Fast, inexpensive method for qualitative and quantitative analysis
  • Simultaneous analysis of several samples under identical conditions

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Analytical HPLC and UHPLC Brochures

Chromolith®

Do you need trouble-free speed?
The new Chromolith® HR
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Technique: Analytical HPLC
Product(s): Chromolith® HighResolution HPLC Columns

  • Fast separations with easy method transfer
  • Column performance corresponds to 3 µm particle packed column, and is at least 50% higher than standard Chromolith® columns
  • Back pressure around 2 times lower than particle packed columns
  • 30% longer column lifetime compared to particle packed columns

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UHPLC² It's your choice!
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Technique: Analytical HPLC
Product(s): Chromolith® and Purospher® STAR UHPLC columns

  • Chromolith® Fast Gradient HPLC columns: Fast and robust analysis at low pressure for reliable results even with difficult samples
  • Purospher® STAR RP-18 endcapped UHPLC columns: Excellent peak symmetry, performance and pH stability for highest flexibility and reliability in QC

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LiChrospher®

You can count on us!
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Technique: Analytical HPLC
Product(s): LiChrospher® RP-select B

  • High reliability of HPLC results
  • Excellent batch-to-batch reproducibility
  • Master batch concept eliminates variations between different batches

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Purospher®

Purospher® STAR HPLC and UHPLC column
Outstanding performance  
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Technique: Analytical HPLC
Product(s): Purospher® STAR and UHPLC columns®

  • Best in class RP-18e column for excellent peak symmetry, performance and pH stability
  • Less hydrophobic compounds, faster retention of very hydrophobic compounds
  • Enhanced selectivity for separation of aromatic compounds due to π-π interactions
  • Separation of carbohydrates and polar compounds with normal-phase or HILIC chromatography
  • Separation of polar compounds with normal-phase or HILIC (Si) chromatography
  • Ultra fast for UHPLC and excellent for LC-MS

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Purospher® STAR RP-18 endcapped UPLC columns
Speed meets performance!
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Technique: Analytical HPLC
Product(s): Purospher® STAR RP-18 endcapped UPLC columns

  • Time and cost-saving solution
  • Ultra fast HPLC speeds up separation as much as 10 times, and dramatically cuts solvent consumption
  • Best peak symmetry, high pressure stability, and excellent pH stability

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SeQuant® CARS™ and SAMS™

SeQuant® CARS™ and SAMS™
Everything runs smoothly…
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Technique: Analytical HPLC
Product(s): SeQuant® CARS™ and SAMS™

  • SeQuant® CARS™: Robust suppression system for high ionic strength eluents and gradient applications
  • SeQuant® SAMS™: High-capacity membrane suppressor for enhanced detection in ion chromatography

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SeQuant® ZIC® -HILIC

A practical guide to HILIC
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Technique: Analytical HPLC
Product(s): SeQuant® ZIC® -HILIC HPLC columns

  • Everything needed to get started with HILIC (hydrophilic interaction liquid chromatography)
  • Tips for successful method development and troubleshooting
  • Example applications using SeQuant® ZIC®-HILIC and ZIC®-pHILIC HPLC columns

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SeQuant®
For all who expect more
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Technique: Analytical HPLC
Product(s): SeQuant® ZIC® -HILIC HPLC columns

  • High-performance, advanced hydrophilic interaction liquid chromatography
  • SeQuant® ZIC® -HILIC for the separation of all polar and hydrophilic compounds
  • SeQuant® ZIC®-pHILIC for challenging separations of polar and hydrophilic compounds

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It's hot!
SeQuant® ZIC® -cHILIC
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Technique: Analytical HPLC
Product(s): SeQuant® ZIC® -cHILIC HPLC columns

  • High-performance HILIC columns with complementary selectivity for HPLC separation of polar hydrophilic compounds
  • Maximum LC-MS compatibility with minimized column bleed, excellent reproducibility and robustness

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Sammlungen von HPLC-Anwendungen

Sammlungen von HPLC-Anwendungen

Anwendungshinweise und Methoden

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ChromBook App

Die ChromBook-App für Tablets
Lernen Sie die neue App kennen

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