MAB303 | Anti-Acetylcholinesterase Antibody, clone AE-1

MAB303
100 µg  
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      Übersicht

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      B, Ca, Ch, Gp, H, Mk ELISA, IHC, IP M Purified Monoclonal Antibody
      Description
      Catalogue NumberMAB303
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Acetylcholinesterase Antibody, clone AE-1
      References
      Product Information
      FormatPurified
      PresentationLiquid in 0.02M PB, 0.25M NaCl, pH 7.6, with 0.1% sodium azide.
      Applications
      ApplicationThis Anti-Acetylcholinesterase Antibody, clone AE-1 is validated for use in ELISA, IH, IP for the detection of Acetylcholinesterase.
      Key Applications
      • ELISA
      • Immunohistochemistry
      • Immunoprecipitation
      Application NotesELISA

      Immunohistochemistry

      Western Blot

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenAcetylcholinesterase AChE from human erythrocyte.
      CloneAE-1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityAcetylcholinesterase from human and monkey.
      IsotypeIgG1
      Species Reactivity
      • Bovine
      • Canine
      • Chicken
      • Guinea Pig
      • Human
      • Monkey
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryAcetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally.
      Gene Symbol
      • ACHE
      • N-ACHE
      • acetylcholinesterase
      • AChE
      • YT
      • ARACHE
      • EC 3.1.1.7
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P22303 # Rapidly hydrolyzes choline released into the synapse.
      SIZE: 614 amino acids; 67796 Da
      SUBUNIT: Homotetramer; composed of disulfide-linked homodimers. Interacts with PRIMA1. The interaction with PRIMA1 is required to anchor it to the basal lamina of cells and organize into tetramers (By similarity).
      SUBCELLULAR LOCATION: Cell junction, synapse. Secreted (By similarity). Cell membrane; Peripheral membrane protein (By similarity). & Isoform 2: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side (By similarity).
      SIMILARITY: SwissProt: P22303 ## Belongs to the type-B carboxylesterase/lipase family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C for up to 6 months.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Analysenzertifikate

      TitelChargennummer
      MOUSE ANTI-ACETYLCHOLINESTERASE 2477972
      MOUSE ANTI-ACETYLCHOLINESTERASE -2774114 2774114
      MOUSE ANTI-ACETYLCHOLINESTERASE -2804191 2804191
      MOUSE ANTI-ACETYLCHOLINESTERASE MONOCLONAL ANTIBODY 3062761
      MOUSE ANTI-ACETYLCHOLINESTERASE MONOCLONAL ANTIBODY 2967227
      MOUSE ANTI-ACETYLCHOLINESTERASE MONOCLONAL ANTIBODY - 2092681 2092681
      MOUSE ANTI-ACETYLCHOLINESTERASE MONOCLONAL ANTIBODY - 2015550 2015550
      MOUSE ANTI-ACETYLCHOLINESTERASE MONOCLONAL ANTIBODY - 2031326 2031326
      MOUSE ANTI-ACETYLCHOLINESTERASE MONOCLONAL ANTIBODY - 2044290 2044290
      MOUSE ANTI-ACETYLCHOLINESTERASE MONOCLONAL ANTIBODY - 2060960 2060960

      Literatur

      ÜbersichtAnwendungSpeziesPub Med ID
      Acetylcholinesterase overexpression mediated by oncolytic adenovirus exhibited potent anti-tumor effect.
      Xu, H; Shen, Z; Xiao, J; Yang, Y; Huang, W; Zhou, Z; Shen, J; Zhu, Y; Liu, XY; Chu, L
      BMC cancer  14  668  2014

      Abstract anzeigen
      25220382 25220382
      Production and purification of polymerization-competent HIV-1 capsid protein p24 (CA) in NiCo21(DE3) Escherichia coli.
      Teow, SY; Mualif, SA; Omar, TC; Wei, CY; Yusoff, NM; Ali, SA
      BMC biotechnology  13  107  2013

      Abstract anzeigen
      24304876 24304876
      Chemical analysis and acetylcholinesterase inhibitory effect of anthocyanin-rich red leaf tea (cv. Sunrouge).
      Mari Maeda-Yamamoto,Takeshi Saito,Atsushi Nesumi,Yoshiko Tokuda,Kaori Ema,Daiki Honma,Akiko Ogino,Manami Monobe,Akira Murakami,Hirofumi Tachibana
      Journal of the science of food and agriculture  92  2012

      Abstract anzeigen
      22419270 22419270
      Effects on contralateral muscles after unilateral electrical muscle stimulation and exercise.
      Song, Y; Forsgren, S; Yu, J; Lorentzon, R; Stål, PS
      PloS one  7  e52230  2012

      Abstract anzeigen
      23284946 23284946
      HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells.
      Lenassi M, Cagney G, Liao M, Vaupotic T, Bartholomeeusen K, Cheng Y, Krogan NJ, Plemenitas A, Peterlin BM
      Traffic  11  110-22.  2010

      Abstract anzeigen Volltextartikel
      19912576 19912576
      The Cholinesterase-like Domain, Essential in Thyroglobulin Trafficking for Thyroid Hormone Synthesis, Is Required for Protein Dimerization.
      Jaemin Lee, Xiaofan Wang, Bruno Di Jeso, Peter Arvan, Jaemin Lee, Xiaofan Wang, Bruno Di Jeso, Peter Arvan, Jaemin Lee, Xiaofan Wang, Bruno Di Jeso, Peter Arvan, Jaemin Lee, Xiaofan Wang, Bruno Di Jeso, Peter Arvan
      The Journal of biological chemistry  284  12752-61  2009

      Abstract anzeigen Volltextartikel
      19276074 19276074
      Inhibition of acetylcholinesterase in CSF versus brain assessed by 11C-PMP PET in AD patients treated with galantamine.
      T Darreh-Shori, A Kadir, O Almkvist, M Grut, A Wall, G Blomquist, B Eriksson, B Långström, A Nordberg
      Neurobiology of aging  29  168-84  2008

      Abstract anzeigen
      17196712 17196712
      The cholinesterase-like domain of thyroglobulin functions as an intramolecular chaperone.
      Jaemin Lee,Bruno Di Jeso,Peter Arvan
      The Journal of clinical investigation  118  2008

      Abstract anzeigen Volltextartikel
      18596923 18596923
      Changes in the activity and protein levels of CSF acetylcholinesterases in relation to cognitive function of patients with mild Alzheimer's disease following chronic donepezil treatment.
      T Darreh-Shori, L Meurling, T Pettersson, K Hugosson, E Hellström-Lindahl, N Andreasen, L Minthon, A Nordberg
      Journal of neural transmission (Vienna, Austria : 1996)  113  1791-801  2006

      Abstract anzeigen
      16868793 16868793
      Axodendritic contacts onto calcium/calmodulin-dependent protein kinase type II-expressing neurons in the barn owl auditory space map.
      Rodriguez-Contreras, A; Liu, XB; DeBello, WM
      The Journal of neuroscience : the official journal of the Society for Neuroscience  25  5611-22  2005

      Abstract anzeigen
      Immunofluorescence15944389 15944389

      Datenblatt

      Titel
      MOUSE ANTI-ACETYLCHOLINESTERASE MONOCLONAL ANTIBODY

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      Life Science Research > Antibodies and Assays > Primary Antibodies