MAB5504 Anti-Vesicular Glutamate Transporter 2 Antibody

MAB5504
100 µg  
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      Übersicht

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R WB, IHC M Purified Monoclonal Antibody
      Description
      Catalogue NumberMAB5504
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Vesicular Glutamate Transporter 2 Antibody
      Alternate Names
      • VGLUT2
      Background InformationVesicular Glutamate Transporter 2 (VGLUT2) is a sodium dependent inorganic phosphate cotransporter that is involved in the calcium dependent glutamate release from astrocytes. It is expressed in only a subset of neurons, localized to synaptic vesicles, at synapses exhibiting classical excitatory features. VGLUT2 mRNA is found in brain regions that lack VGLUT1, a related protein also displaying sodium dependent inorganic phosphate cotransporter activity.
      References
      Product Information
      FormatPurified
      Control
      • Brain tissue
      PresentationMouse monoclonal in PBS containing 0.1% sodium azide.
      Applications
      ApplicationDetect Vesicular Glutamate Transporter 2 using this Anti-Vesicular Glutamate Transporter 2 Antibody validated for use in WB, IH.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry: A 1:50-1:300 dilution of a previous lot worked using ABC with NiDAB on floating mouse brain sections.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenRecombinant protein from rat VGLUT2.
      Clone8G9.2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityReacts with VGLUT2 (Vesicular Glutamate Transporter 2).
      IsotypeIgG1
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Species Reactivity NoteMouse and rat. Expected to react with human based on sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SLC17A6
      • DNPI
      • VGLUT2
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also play a role in the endocrine glutamatergic system of other tissues such as pineal gland and pancreas. May also mediate the transport of inorganic phosphate.
      SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane; Multi-pass membrane protein (Potential). Cell junction, synapse, synaptosome.
      TISSUE SPECIFICITY: Expressed in brain (at protein level). Expressed in brainstem, deep nuclei, septal nuclei, nuclei of the diagonal band, frontal cortex, hypothalamus, midbrain, parietal cortex and temporal cortex. Also expressed in pineal gland and islets of Langerhans.
      SIMILARITY: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.

      SIZE: 582 amino acids; 64392 Da
      Molecular Weight56 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot on Mouse brain lysates.

      Western Blotting Analysis: 1:500 dilution of this antibody detected VGLUT2 on 10 µg of Mouse brain lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Analysenzertifikate

      TitelChargennummer
      Anti-Vesicular Glutamate Transporter -26416702641670
      Anti-Vesicular Glutamate Transporter -27898022789802
      Anti-Vesicular Glutamate Transporter -28174712817471
      Anti-Vesicular Glutamate Transporter 2 - 21421762142176
      Anti-Vesicular Glutamate Transporter 2 - 23939262393926
      Anti-Vesicular Glutamate Transporter 2 - 19764041976404
      Anti-Vesicular Glutamate Transporter 2 - 20123632012363
      Anti-Vesicular Glutamate Transporter 2 - 20431932043193
      Anti-Vesicular Glutamate Transporter 2 - 20904512090451
      Anti-Vesicular Glutamate Transporter 2 - 22251632225163

      Literatur

      ÜbersichtAnwendungSpeziesPub Med ID
      Interplay between glucose and leptin signalling determines the strength of GABAergic synapses at POMC neurons.
      Lee, DK; Jeong, JH; Chun, SK; Chua, S; Jo, YH
      Nature communications  6  6618  2015

      Abstract anzeigen
      25808323 25808323
      Processing of visually evoked innate fear by a non-canonical thalamic pathway.
      Wei, P; Liu, N; Zhang, Z; Liu, X; Tang, Y; He, X; Wu, B; Zhou, Z; Liu, Y; Li, J; Zhang, Y; Zhou, X; Xu, L; Chen, L; Bi, G; Hu, X; Xu, F; Wang, L
      Nature communications  6  6756  2015

      Abstract anzeigen
      25854147 25854147
      Dopaminergic and glutamatergic microdomains in a subset of rodent mesoaccumbens axons.
      Zhang, S; Qi, J; Li, X; Wang, HL; Britt, JP; Hoffman, AF; Bonci, A; Lupica, CR; Morales, M
      Nature neuroscience  18  386-92  2015

      Abstract anzeigen
      25664911 25664911
      Cerebellar zonal patterning relies on Purkinje cell neurotransmission.
      White, JJ; Arancillo, M; Stay, TL; George-Jones, NA; Levy, SL; Heck, DH; Sillitoe, RV
      The Journal of neuroscience : the official journal of the Society for Neuroscience  34  8231-45  2014

      Abstract anzeigen
      24920627 24920627
      Histological features of layers and sublayers in cortical visual areas V1 and V2 of chimpanzees, macaque monkeys, and humans.
      Balaram, P; Young, NA; Kaas, JH
      Eye and brain  2014  5-18  2014

      Abstract anzeigen
      25788835 25788835
      Multiple knockout mouse models reveal lincRNAs are required for life and brain development.
      Sauvageau, M; Goff, LA; Lodato, S; Bonev, B; Groff, AF; Gerhardinger, C; Sanchez-Gomez, DB; Hacisuleyman, E; Li, E; Spence, M; Liapis, SC; Mallard, W; Morse, M; Swerdel, MR; D'Ecclessis, MF; Moore, JC; Lai, V; Gong, G; Yancopoulos, GD; Frendewey, D; Kellis, M; Hart, RP; Valenzuela, DM; Arlotta, P; Rinn, JL
      eLife  2  e01749  2013

      Abstract anzeigen
      24381249 24381249
      Torsin A Localization in the Mouse Cerebellar Synaptic Circuitry.
      Puglisi, F; Vanni, V; Ponterio, G; Tassone, A; Sciamanna, G; Bonsi, P; Pisani, A; Mandolesi, G
      PloS one  8  e68063  2013

      Abstract anzeigen
      23840813 23840813
      Establishment of topographic circuit zones in the cerebellum of scrambler mutant mice.
      Reeber, SL; Loeschel, CA; Franklin, A; Sillitoe, RV
      Frontiers in neural circuits  7  122  2013

      Abstract anzeigen
      23885237 23885237
      Reduction of mutant ataxin-7 expression restores motor function and prevents cerebellar synaptic reorganization in a conditional mouse model of SCA7.
      Furrer, SA; Waldherr, SM; Mohanachandran, MS; Baughn, TD; Nguyen, KT; Sopher, BL; Damian, VA; Garden, GA; La Spada, AR
      Human molecular genetics  22  890-903  2013

      Abstract anzeigen
      23197655 23197655
      Morphological and neurochemical comparisons between pulvinar and V1 projections to V2.
      Marion, R; Li, K; Purushothaman, G; Jiang, Y; Casagrande, VA
      The Journal of comparative neurology  521  813-32  2013

      Abstract anzeigen
      22826174 22826174

      Datenblatt

      Titel
      Anti-Vesicular Glutamate Transporter 2 - Data Sheet

      Verwandte Produkte & Anwendungen

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      Kategorien

      Life Science Research > Antibodies and Assays > Primary Antibodies