513030 | PD 169316 - CAS 152121-53-4 - Calbiochem

513030
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      Overview

      Replacement Information

      Tabella delle specifiche principali

      Empirical Formula CAS #
      C₂₀H₁₃FN₄O₂ 152121-53-4

      Prezzi e disponibilità

      Numero di catalogoDisponibilità Confezionamento Qtà/conf Prezzo Quantità
      513030-1MG
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          1 mg
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          Description
          Overview A potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC50 = 89 nM). Inhibition of p38 MAP kinase by PD 169316 blocks apoptosis induced by trophic factor withdrawal in non-neuronal and neuronal cell lines.
          Catalogue Number 513030
          Brand Family Calbiochem®
          Synonyms 4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole
          References
          References Nath, R., et al. 2001. Cell Mol. Biol. Lett. 6, 173.
          Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
          Kummer, J.L., et al. 1997. J. Biol. Chem. 272, 20490.
          Product Information
          CAS number 152121-53-4
          ATP Competitive Y
          Form Orange-yellow solid
          Hill Formula C₂₀H₁₃FN₄O₂
          Chemical formula C₂₀H₁₃FN₄O₂
          Molar Mass 360.3
          Reversible Y
          Structure formula Image
          Applications
          Biological Information
          Primary Target p38 MAP kinase
          Primary Target IC50 89 nM against p38 MAP kinase
          Purity ≥98% by HPLC
          Physicochemical Information
          Cell permeable Y
          Solubility DMSO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          MSDS

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          Certificati d'Analisi

          TitoloNumero di lotto
          513030

          Riferimenti bibliografici

          Panoramica delle referenze
          Nath, R., et al. 2001. Cell Mol. Biol. Lett. 6, 173.
          Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
          Kummer, J.L., et al. 1997. J. Biol. Chem. 272, 20490.
          Scheda tecnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision 04-January-2010 RFH
          Synonyms 4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole
          Description A potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC50= 89 nM). Inhibition of p38 MAP kinase by PD 169316 blocks apoptosis induced by trophic factor withdrawal in non-neuronal and neuronal cell lines.
          Form Orange-yellow solid
          CAS number 152121-53-4
          Molar mass 360.3
          Chemical formula C₂₀H₁₃FN₄O₂
          Structure formula
          Purity ≥98% by HPLC
          Solubility DMSO (10 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
          Toxicity Standard Handling
          References Nath, R., et al. 2001. Cell Mol. Biol. Lett. 6, 173.
          Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
          Kummer, J.L., et al. 1997. J. Biol. Chem. 272, 20490.