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AB15552-50UL | Anti-AT1 Receptor Antibody

AB15552-50UL
50 µL  
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      Descripción

      Replacement Information

      Ofertas especiales

      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R FC, ICC, IHC, WB Rb Purified Polyclonal Antibody
      Description
      Catalogue NumberAB15552-50UL
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-AT1 Receptor Antibody
      Alternate Names
      • Angiotensin II receptory type 1
      • AGTR1
      References
      Product Information
      FormatPurified
      Control
      • Included free of charge with the antibody is 40 µg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 µL of sterile deionized water. For negative control, preincubate 1 µg of peptide with 1 µg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
      PresentationLyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.025% sodium azide as a preservative. Reconstitute with 50 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min).
      Applications
      ApplicationAnti-AT1 Receptor Antibody detects level of AT1 Receptor & has been published & validated for use in FC, IC, IH & WB.
      Key Applications
      • Flow Cytometry
      • Immunocytochemistry
      • Immunohistochemistry
      • Western Blotting
      Application NotesWestern blot: 1:200-1:500 using ECL on rat liver, rat kidney, mouse heart and mouse kidney lysate.
      Immunohistochemistry on rat brain sections.
      Immunocytochemistry: 1:100
      Flow cytometry, indirect: 5-10 µg of antibody /1 x 106 cells
      Dilutions should be made using a carrier protein such as BSA (1-3%).
      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenPurified peptide from the N-terminus of human AT1 Receptor (Accession number P30556).
      HostRabbit
      SpecificityRecognizes AT1 Receptor (Angiotensin II receptory type 1, AGTR1).
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Species Reactivity NoteThe immunogen sequence is identical in canine.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryAngiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. At least four transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants.
      Gene Symbol
      • AGTR1
      • AT2R1A
      • AT2R1B
      • AGTR1B
      • AT2R1
      • AT1BR
      • AGTR1A
      • AT1AR
      • AG2S
      • HAT1R
      • AT1
      • AT1B
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P30556 # Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.
      SIZE: 359 amino acids; 41061 Da
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Liver, lung, adrenal and adrenocortical adenomas.
      PTM: C-terminal Ser or Thr residues may be phosphorylated.
      DISEASE: SwissProt: P30556 # Defects in AGTR1 are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
      SIMILARITY: SwissProt: P30556 ## Belongs to the G-protein coupled receptor 1 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Certificados de análisis

      CargoNúmero de lote
      RABBIT ANTI-AT1 RECEPTOR AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2441965 2441965
      RABBIT ANTI-AT1 RECEPTOR AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2444068 2444068
      RABBIT ANTI-AT1 RECEPTOR - 2519324 2519324
      RABBIT ANTI-AT1 RECEPTOR AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2040906 2040906
      RABBIT ANTI-AT1 RECEPTOR AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2197180 2197180
      RABBIT ANTI-AT1 RECEPTOR AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2294345 2294345
      RABBIT ANTI-AT1 RECEPTOR AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2352401 2352401

      Ficha técnica

      Cargo
      RABBIT ANTI-AT1 RECEPTOR AFFINITY PURIFIED POLYCLONAL ANTIBODY - Data Sheet

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      Categorías

      Life Science Research > Antibodies and Assays > Primary Antibodies