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CBL519 | Anti-CD57 Antibody, clone NK-1

CBL519
100 µg  
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      Descripción

      Replacement Information

      Ofertas especiales

      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H FC, IHC, IH(P) M Purified Monoclonal Antibody
      Description
      Catalogue NumberCBL519
      ReplacesCBL519B
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-CD57 Antibody, clone NK-1
      Alternate Names
      • HNK-1
      • Leu-7
      References
      Product Information
      FormatPurified
      PresentationThe monoclonal is presented in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application.
      Applications
      ApplicationThis Anti-CD57 Antibody, clone NK-1 is validated for use in FC, IH, IH(P) for the detection of CD57.
      Key Applications
      • Flow Cytometry
      • Immunohistochemistry
      • Immunohistochemistry (Paraffin)
      Application NotesFormalin fixed paraffin wax embedded sections

      Frozen sections

      Flow cytometry

      Analysis of NK cell-mediated cytotoxicity

      Studies of functional properties of NK cell and T cell subsets

      Studies of neural tissue glycoproteins

      Optimal working dilutions must be determined by the end user.
      Biological Information
      CloneNK-1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThe antibody reacts with a carbohydrate antigen present on a subset of peripheral blood mononuclear cells involved in the natural killer activity, which is not MHC restricted. The antigen is not present on B cells, monocytes, red blood cells or platelets but is expressed on cells in neuroectodermal tissue. It reacts with 20% of normal human peripheral blood mononuclear cells.
      IsotypeIgM
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). Alternate transcriptional splice variants have been characterized.
      Gene Symbol
      • B3GAT1
      • HNK1
      • Glucuronosyltransferase-P
      • GLCATP
      • NK-1
      • HNK-1
      • LEU7
      • GlcUAT-P
      • CD57
      • GlcAT-P
      • EC 2.4.1.135
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9P2W7 # Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo- orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl- sphingomyelin was the most effective, followed by palmitoyl- sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group (By similarity).
      COFACTOR: Manganese.
      SIZE: 334 amino acids; 38355 Da
      SUBUNIT: Homodimer (Potential).
      SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type II membrane protein.
      TISSUE SPECIFICITY: Mainly expressed in the brain.
      SIMILARITY: SwissProt: Q9P2W7 ## Belongs to the glycosyltransferase 43 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsFor use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C for up to one year.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Certificados de análisis

      CargoNúmero de lote
      MOUSE ANTI-HUMAN CD57 MONOCLONAL ANTIBODY - 2452193 2452193
      MOUSE ANTI-HUMAN CD57 MONOCLONAL ANTIBODY - 2216876 2216876
      MOUSE ANTI-HUMAN CD57 MONOCLONAL ANTIBODY -2548044 2548044
      MOUSE ANTI-HUMAN CD57 MONOCLONAL ANTIBODY -2608150 2608150

      Referencias bibliográficas

      Visión general referenciasPub Med ID
      Recognition of myelin-associated glycoprotein by the monoclonal antibody HNK-1.
      McGarry, R C, et al.
      Nature, 306: 376-8 (1983) 1983

      Mostrar resumen
      6196641 6196641
      Subpopulations of human natural killer cells defined by expression of the Leu-7 (HNK-1) and Leu-11 (NK-15) antigens.
      Lanier, L L, et al.
      J. Immunol., 131: 1789-96 (1983) 1983

      Mostrar resumen
      6225799 6225799
      A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1).
      Abo, T and Balch, C M
      J. Immunol., 127: 1024-9 (1981) 1981

      6790607 6790607

      Ficha técnica

      Cargo
      Anti-CD57, clone NK-1 - Data Sheet