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MAB3326 | Anti-Collagen Type IV Antibody, 7S Domain, clone IV-4H12

MAB3326
100 µg  
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      Descripción

      Replacement Information

      Ofertas especiales

      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H ELISA, WB, IH(P) M Purified Monoclonal Antibody
      Description
      Catalogue NumberMAB3326
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Collagen Type IV Antibody, 7S Domain, clone IV-4H12
      References
      Product Information
      FormatPurified
      Control
      • POSITIVE CONTROL: human placental tissues.
      PresentationLiquid in 0.1 M sodium phosphate buffer, pH 7.0, containing 2% protease-free bovine serum albumin.
      Applications
      ApplicationThis Anti-Collagen Type IV Antibody, 7S Domain, clone IV-4H12 is validated for use in ELISA, WB, IH(P) for the detection of Collagen Type IV.
      Key Applications
      • ELISA
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesWestern blot. Detects human type IV collagen from human placental tissues at 2 μg/mL, giving a band at approximately 92 kDa. Optimal working dilutions must be determined by end user.
      Biological Information
      Epitope7S Domain
      CloneIV-4H12
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificitySpecifically reactive with human Type IV Collagen.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes the major type IV alpha collagen chain of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.
      Gene Symbol
      • COL4A1
      • Arresten
      • arresten
      Non-Reactive Species
      • Rat
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P02462 # Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Potently inhibits endothelial cell proliferation and angiogenesis. Inhibits angiogenesis potentially via mechanisms involving cell surface proteoglycans and the alpha and beta integrins of endothelial cells.
      SIZE: 1669 amino acids; 160615 Da
      SUBUNIT: There are six type IV collagen isoforms, alpha 1(IV)- alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network.
      SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane.
      TISSUE SPECIFICITY: Highly expressed in placenta.
      DOMAIN: SwissProt: P02462 Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G- X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain.
      PTM: Lysines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in all cases and bind carbohydrates. & Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. & Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens. & The trimeric structure of the NC1 domains may be stabilized by covalent bonds between Lys and Met residues.
      DISEASE: SwissProt: P02462 # Defects in COL4A1 are a cause of brain small vessel disease with hemorrhage [MIM:607595]. Brain small vessel diseases underlie 20 to 30 percent of ischemic strokes and a larger proportion of intracerebral hemorrhages. Inheritance is autosomal dominant. & Defects in COL4A1 are a cause of porencephaly type 1 [MIM:175780]; also known as encephaloclastic porencephaly. Porencephaly is a term used for any cavitation or cerebrospinal fluid-filled cyst in the brain. Porencephaly type 1 is usually unilateral and results from focal destructive lesions such as fetal vascular occlusion or birth trauma. Inheritance is autosomal dominant.
      SIMILARITY: Belongs to the type IV collagen family. & Contains 2 COL4C (collagen IV C-terminal) domains.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Availability by Geography
      • This product is not available for sale in Japan.
      Usage Statement
      • Manufactured by Daiichi Fine Chemical Co., Ltd
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain frozen at -20°C in undiluted aliquots for up to 12 months.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Certificados de análisis

      CargoNúmero de lote
      MOUSE ANTI-TYPE IV COLLAGEN, 7S DOMAIN -2695260 2695260
      MOUSE ANTI-TYPE IV COLLAGEN, 7S DOMAIN -2842112 2842112
      MOUSE ANTI-TYPE IV COLLAGEN, 7S DOMAIN MONOCLONAL ANTIBODY - 2145046 2145046
      MOUSE ANTI-TYPE IV COLLAGEN, 7S DOMAIN MONOCLONAL ANTIBODY - 2436344 2436344
      MOUSE ANTI-TYPE IV COLLAGEN, 7S DOMAIN MONOCLONAL ANTIBODY - 2069938 2069938
      MOUSE ANTI-TYPE IV COLLAGEN, 7S DOMAIN MONOCLONAL ANTIBODY - 2277813 2277813
      MOUSE ANTI-TYPE IV COLLAGEN, 7S DOMAIN MONOCLONAL ANTIBODY -2472891 2472891
      MOUSE ANTI-TYPE IV COLLAGEN, 7S DOMAIN MONOCLONAL ANTIBODY -2615060 2615060
      MOUSE ANTI-TYPE IV COLLAGEN, 7S DOMAIN MONOCLONAL ANTIBODY -2766508 2766508

      Referencias bibliográficas

      Visión general referenciasPub Med ID
      Mural cell associated VEGF is required for organotypic vessel formation.
      Evensen, L; Micklem, DR; Blois, A; Berge, SV; Aarsaether, N; Littlewood-Evans, A; Wood, J; Lorens, JB
      PloS one 4 e5798 2009

      Mostrar resumen Artículo Texto completo
      19495422 19495422
      Contribution of hepatic stellate cells and matrix metalloproteinase 9 in acute liver failure.
      Chunli Yan, Ling Zhou, Yuan-Ping Han, Chunli Yan, Ling Zhou, Yuan-Ping Han
      Liver international : official journal of the International Association for the Study of the Liver 28 959-71 2008

      Mostrar resumen
      18507761 18507761
      The effect of functionalized self-assembling peptide scaffolds on human aortic endothelial cell function.
      Elsa Genové, Colette Shen, Shuguang Zhang, Carlos E Semino
      Biomaterials 26 3341-51 2005

      Mostrar resumen
      15603830 15603830

      Ficha técnica

      Cargo
      Anti-Collagen Type IV, 7S Domain, clone IV-4H12 - Data Sheet

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      Categorías

      Life Science Research > Antibodies and Assays > Primary Antibodies