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AB1726 | Anti-Connexin 40 Antibody

AB1726
50 µg  
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      Replacement Information

      Ofertas especiales

      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R WB, IHC Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberAB1726
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Connexin 40 Antibody
      Alternate Names
      • Cx40
      • Gap Junction alpha-5 Protein
      • CxA-5
      Background InformationMouse Connexin 40 is a 358 amino acid gap junction protein with a predicted M.W. of ~40 kDa. It is prominently expressed in lung, heart and skin (see reviews: Kumar & Giula 1996; White, 1995; Evans, 1994; Beyer , 1990; Henneman, 1992; Traub, 1994; Goliger & Paul 1994). One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Placenta lysate.
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 15 mM NaCl containing 0.05% sodium azide.
      Applications
      ApplicationAnti-Connexin 40 Antibody is an antibody against Cx40 for use in IHC & WB.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: An 1:50 dilution of a representative lot detected Connexin 40 immunoreactivity associated with the gap junction between the cardiac myoepithial cells in mouse heart tissue sections.
      Western Blot Analysis: An 1:1000 dilution of a representative lot detected Connexin 40 in human (HEK293, HeLa, HepG2, HUVEC, Jurkat) and murine (C2C12, HIN/3T3) cell lysates.
      Western Blot Analysis: An 1:000 dilution of a representative lot detected Connexin 40 in human, mouse, and rat heart tissue homogenates, as well as in mouse brain tissue homogenates.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenAnti-Connexin 40 is made against a 19 amino acid peptide sequence within the C-terminal cytoplasmic domain of mouse C×40 (2). Peptide sequence is conserved in human and rat Cx40 (100%), chicken Cx42 (77%), human Cx50 (87%), rat Cx50 (81%) and sheep Cx49 (87%).
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityReacts with mouse connexin 40.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Species Reactivity NoteHuman, mouse, and rat. Reactivity with other species has not been determined.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene may be associated with atrial fibrillation. Alternatively spliced transcript variants encoding the same isoform have been described. [provided by RefSeq]
      Gene Symbol
      • GJA5
      • CX40
      • Connexin-40
      • MGC11185
      • Cx40
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P36382 # One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
      SIZE: 358 amino acids; 40380 Da
      SUBUNIT: A connexon is composed of a hexamer of connexins.
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
      DISEASE: SwissProt: P36382 # Defects in GJA5 are the cause of atrial fibrillation type 4 (ATFB4) [MIM:108770]; also known as atrial standstill. ATFB is characterized by rapid and irregular activation of the atrium.
      SIMILARITY: SwissProt: P36382 ## Belongs to the connexin family. Alpha-type (group II) subfamily
      Molecular Weight40 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot on Jurkat lysates.

      Western Blot Analysis: A 1:1000 dilution of this lot detected Connexin 40 in 10 μg of Jurkat lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Certificados de análisis

      CargoNúmero de lote
      Anti-Connexin 40 - 2458946 2458946
      Anti-Connexin 40 - 2022024 2022024
      Anti-Connexin 40 - 2090067 2090067
      Anti-Connexin 40 - 2210333 2210333
      Anti-Connexin 40 - 2326294 2326294
      Anti-Connexin 40 - JBC1766733 JBC1766733
      Anti-Connexin 40 - NG1723899 NG1723899
      Anti-Connexin 40 - NG1823967 NG1823967
      Anti-Connexin 40 - NG1853831 NG1853831
      Anti-Connexin 40 - NG1919854 NG1919854
      Anti-Connexin 40 -2496161 2496161
      Anti-Connexin 40 -2552346 2552346
      Anti-Connexin 40 -2605428 2605428
      Anti-Connexin 40 -2654606 2654606
      Anti-Connexin 40 -2701543 2701543
      Anti-Connexin 40 -2762376 2762376

      Referencias bibliográficas | 26 Disponible | Ver todas las referencias

      Visión general referenciasAplicación Pub Med ID
      Arterial dysfunction but maintained systemic blood pressure in cavin-1-deficient mice.
      Swärd, K; Albinsson, S; Rippe, C
      PloS one 9 e92428 2014

      Mostrar resumen
      Western Blotting24658465 24658465
      High flow conditions increase connexin43 expression in a rat arteriovenous and angioinductive loop model.
      Schmidt, VJ; Hilgert, JG; Covi, JM; Weis, C; Wietbrock, JO; de Wit, C; Horch, RE; Kneser, U
      PloS one 8 e78782 2013

      Mostrar resumen
      24236049 24236049
      Inverse Relationship between Tumor Proliferation Markers and Connexin Expression in a Malignant Cardiac Tumor Originating from Mesenchymal Stem Cell Engineered Tissue in a Rat in vivo Model.
      Spath, C; Schlegel, F; Leontyev, S; Mohr, FW; Dhein, S
      Frontiers in pharmacology 4 42 2013

      Mostrar resumen
      23616767 23616767
      Role of connexin-43 in protective PI3K-Akt-GSK-3β signaling in cardiomyocytes.
      Ishikawa, S; Kuno, A; Tanno, M; Miki, T; Kouzu, H; Itoh, T; Sato, T; Sunaga, D; Murase, H; Miura, T
      American journal of physiology. Heart and circulatory physiology 302 H2536-44 2012

      Mostrar resumen
      22505645 22505645
      Role of connexin40 in the autoregulatory response of the afferent arteriole.
      Sorensen, CM; Giese, I; Braunstein, TH; Brasen, JC; Salomonsson, M; Holstein-Rathlou, NH
      American journal of physiology. Renal physiology 303 F855-63 2012

      Mostrar resumen
      22811484 22811484
      GM-CSF causes a Paradoxical Increase in the BH3-only Pro-Apoptotic Protien BIM in Human Neutrophils.
      Cowburn AS, Summers C, Dunmore BJ, Farahi N, Hayhoe RP, Print CG, Cook SJ, Chilvers ER
      Am J Respir Cell Mol Biol 2010

      Mostrar resumen
      20705940 20705940
      An angiotensin II- and NF-kappaB-dependent mechanism increases connexin 43 in murine arteries targeted by renin-dependent hypertension.
      Alonso, F; Krattinger, N; Mazzolai, L; Simon, A; Waeber, G; Meda, P; Haefliger, JA
      Cardiovascular research 87 166-76 2010

      Mostrar resumen Artículo Texto completo
      20110337 20110337
      Loss of connexin40 is associated with decreased endothelium-dependent relaxations and eNOS levels in the mouse aorta.
      Alonso, F; Boittin, FX; Bény, JL; Haefliger, JA
      American journal of physiology. Heart and circulatory physiology 299 H1365-73 2010

      Mostrar resumen
      20802140 20802140
      Role of caveolar compartmentation in endothelium-derived hyperpolarizing factor-mediated relaxation: Ca2+ signals and gap junction function are regulated by caveolin in endothelial cells.
      Saliez, J; Bouzin, C; Rath, G; Ghisdal, P; Desjardins, F; Rezzani, R; Rodella, LF; Vriens, J; Nilius, B; Feron, O; Balligand, JL; Dessy, C
      Circulation 117 1065-74 2008

      Mostrar resumen
      18268148 18268148
      Connexin mimetic peptides fail to inhibit vascular conducted calcium responses in renal arterioles.
      Sorensen, CM; Salomonsson, M; Braunstein, TH; Nielsen, MS; Holstein-Rathlou, NH
      American journal of physiology. Regulatory, integrative and comparative physiology 295 R840-7 2008

      Mostrar resumen
      Immunofluorescence18614765 18614765

      Ficha técnica

      Cargo
      Anti-Connexin 40 - Data Sheet