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MAB1940 | Anti-Fibronectin Antibody, cellular, clone DH1

MAB1940
50 µg  
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      Descripción

      Replacement Information

      Ofertas especiales

      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      Gp, H, R, Rb WB, IHC M Purified Monoclonal Antibody
      Description
      Catalogue NumberMAB1940
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Fibronectin Antibody, cellular, clone DH1
      References
      Product Information
      FormatPurified
      PresentationIn PBS with 1% BSA and 0.1% sodium azide.
      Applications
      ApplicationDetect Fibronectin using this Anti-Fibronectin Antibody, cellular, clone DH1 validated for use in WB, IH.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunoblotting at 1:1,000

      Indirect immunohistochemistry at 1:200-1:400

      A 1-hour fixation with 3-3.5% paraformaldehyde in 0.1 M phosphate buffer pH 7.4 is suggested. Shows some reactivity on paraffin sections depending on fixation conditions and time (Latvala et al., 1996).

      Final working dilutions must be determined by end user.
      Biological Information
      ImmunogenPurified fibronectin from Human A8387 fibrosarcoma cells.
      Epitopecellular
      CloneDH1
      HostMouse
      SpecificitySpecific for the extra domain of cellular fibronectin (EDA sequence) and thus recognizes only the cellular fibronectin.
      IsotypeIgG1
      Species Reactivity
      • Guinea Pig
      • Human
      • Rat
      • Rabbit
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined.
      Gene Symbol
      • FN1
      • DKFZp686H0342
      • DKFZp686I1370
      • MSF
      • CIG
      • LETS
      • DKFZp686O13149
      • FN
      • DKFZp686F10164
      • FINC
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P02751 # Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Interaction with TNR mediates inhibition of cell adhesion and neurite outgrowth (By similarity).
      SIZE: 2386 amino acids; 262607 Da
      SUBUNIT: Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, AMBP, TNR, LGALS3BP and COL13A1.
      SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
      TISSUE SPECIFICITY: Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine.DEVELOPMENTAL STAGE: Ugl-Y1, Ugl-Y2 and Ugl-Y3 are present in the urine from 0 to 17 years of age.
      PTM: Sulfated.
      SIMILARITY: SwissProt: P02751 ## Contains 12 fibronectin type-I domains. & Contains 2 fibronectin type-II domains. & Contains 16 fibronectin type-III domains.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at +2-8°C for up to 12 months.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Certificados de análisis

      CargoNúmero de lote
      Anti-Bromodeoxyuridine, clone IIB5 -2764022 2764022
      MOUSE ANTI-CELLULAR FIBRONECTIN MONOCLONAL ANTIBODY - 2428452 2428452
      MOUSE ANTI-CELLULAR FIBRONECTIN MONOCLONAL ANTIBODY - 2444039 2444039
      MOUSE ANTI-CELLULAR FIBRONECTIN - 2512415 2512415
      MOUSE ANTI-CELLULAR FIBRONECTIN -2566783 2566783
      MOUSE ANTI-CELLULAR FIBRONECTIN -2601711 2601711
      MOUSE ANTI-CELLULAR FIBRONECTIN -2651991 2651991
      MOUSE ANTI-CELLULAR FIBRONECTIN -2659246 2659246
      MOUSE ANTI-CELLULAR FIBRONECTIN -2661386 2661386
      MOUSE ANTI-CELLULAR FIBRONECTIN -2718302 2718302
      MOUSE ANTI-CELLULAR FIBRONECTIN -2764021 2764021
      MOUSE ANTI-CELLULAR FIBRONECTIN MONOCLONAL ANTIBODY - 2101978 2101978
      MOUSE ANTI-CELLULAR FIBRONECTIN MONOCLONAL ANTIBODY - 2202420 2202420
      MOUSE ANTI-CELLULAR FIBRONECTIN MONOCLONAL ANTIBODY - 2297177 2297177

      Referencias bibliográficas | 16 Disponible | Ver todas las referencias

      Visión general referenciasAplicación EspeciePub Med ID
      Expression of myoferlin in human airway epithelium and its role in cell adhesion and zonula occludens-1 expression.
      Leung, C; Shaheen, F; Bernatchez, P; Hackett, TL
      PloS one 7 e40478 2012

      Mostrar resumen
      Western BlottingHuman22808170 22808170
      Refractive lenticule re-implantation after myopic ReLEx: a feasibility study of stromal restoration after refractive surgery in a rabbit model.
      Angunawela, RI; Riau, AK; Chaurasia, SS; Tan, DT; Mehta, JS
      Investigative ophthalmology & visual science 53 4975-85 2012

      Mostrar resumen
      22743323 22743323
      Further expansion of the phenotypic spectrum associated with mutations in ALDH18A1, encoding ?¹-pyrroline-5-carboxylate synthase (P5CS).
      David L Skidmore,David Chitayat,Tim Morgan,Alek Hinek,Bjoern Fischer,Aikaterini Dimopoulou,Gino Somers,William Halliday,Susan Blaser,Yenge Diambomba,Edmond G Lemire,Uwe Kornak,Stephen P Robertson
      American journal of medical genetics. Part A 155A 2011

      Mostrar resumen
      21739576 21739576
      Selegiline is an efficient and potent inducer for bone marrow stromal cell differentiation into neuronal phenotype.
      Mohammad Taghi Ghorbanian,Taki Tiraihi,Seyed A Mesbah-Namin,Yaghoub Fathollahi
      Neurological research 32 2010

      Mostrar resumen
      19422735 19422735
      Serum amyloid P ameliorates radiation-induced oral mucositis and fibrosis.
      Murray, LA; Kramer, MS; Hesson, DP; Watkins, BA; Fey, EG; Argentieri, RL; Shaheen, F; Knight, DA; Sonis, ST
      Fibrogenesis & tissue repair 3 11 2010

      Mostrar resumen
      20602770 20602770
      BMP-7 does not protect against bleomycin-induced lung or skin fibrosis.
      Murray, LA; Hackett, TL; Warner, SM; Shaheen, F; Argentieri, RL; Dudas, P; Farrell, FX; Knight, DA
      PloS one 3 e4039 2008

      Mostrar resumen Artículo Texto completo
      19112509 19112509
      Proteolytic digest derived from bovine Ligamentum Nuchae stimulates deposition of new elastin-enriched matrix in cultures and transplants of human dermal fibroblasts.
      Aleksander Hinek, Yanting Wang, Kela Liu, Thomas F Mitts, Felipe Jimenez
      Journal of dermatological science 39 155-66 2005

      Mostrar resumen
      15925490 15925490
      Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis.
      Surendran, K; Schiavi, S; Hruska, KA
      Journal of the American Society of Nephrology : JASN 16 2373-84 2005

      Mostrar resumen
      Western Blotting15944336 15944336
      Kynurenate production by cultured human astrocytes.
      C Kiss, G Ceresoli-Borroni, P Guidetti, C L Zielke, H R Zielke, R Schwarcz
      Journal of neural transmission (Vienna, Austria : 1996) 110 1-14 2003

      Mostrar resumen
      12541009 12541009
      Retroviral gene therapy vectors for prevention of excimer laser-induced corneal haze.
      Ashley Behrens, Erlinda M Gordon, Li Li, Peng X Liu, Zhenhai Chen, Hongjun Peng, Laurie La Bree, W French Anderson, Frederick L Hall, Peter J McDonnell
      Investigative ophthalmology visual science 43 968-77 2002

      Mostrar resumen
      11923236 11923236

      Folleto

      Cargo
      Human Stem Cell Systems

      Ficha técnica

      Cargo
      Anti-Fibronectin, cellular, clone DH1 - Data Sheet

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      Categorías

      Life Science Research > Antibodies and Assays > Primary Antibodies