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AB1508 | Anti-Glutamate Receptor 4 Antibody

AB1508
100 µg  
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      Replacement Information

      Ofertas especiales

      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R, M IH(P), ICC, IHC, IP, WB Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberAB1508
      Replaces06-308
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Glutamate Receptor 4 Antibody
      Alternate Names
      • AMPA-selective glutamate receptor 4
      • Glutamate receptor ionotropic
      • AMPA 4
      • glutamate receptor 4
      • glutamate receptor, ionotrophic
      • AMPA 4
      Background InformationGlutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; QR->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Rat Brain
      PresentationRabbit purified polyclonal serum in buffer containing 0.1M Tris-Glycine, 0.15M NaCl, 0.05% Sodium Azide, pH7.4
      Applications
      ApplicationThis Anti-Glutamate Receptor 4 Antibody is validated for use in IH(P), IC, IH, IP, WB for the detection of Glutamate Receptor 4.
      Key Applications
      • Immunohistochemistry (Paraffin)
      • Immunocytochemistry
      • Immunohistochemistry
      • Immunoprecipitation
      • Western Blotting
      Application NotesImmunohistochemistry:
      Dilutions of 1:10 – 1:500 were tested on rat brain lysate.
      Can be used for immunocytochemistry using paraformaldehyde or paraformaldehyde/glutaraldehyde fixed tissue with light and electron microscopy. Cryostat and vibratome sections can be used with or without Triton X-100 treatment. Suggested concentrations start at 1-3 μg/mL.

      Western blot analysis can be done at final concentrations of 1-3 μg/mL.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenSynthetic linear peptide.
      EpitopeC-Terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityCat. # AB1508 recognizes C-Terminus of GluR4.
      Species Reactivity
      • Rat
      • Mouse
      Species Reactivity NoteThe immunogen sequence shares 100% conservation with chicken, mouse, rat, oppossum, human, chimp, and monkey.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryGlutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia.
      Gene Symbol
      • GRIA4
      • GluR-D
      • GLUR4C
      • GLUR4
      • GluR4
      • GLURD
      • GluR-4
      Purification MethodAntigen Affinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P48058 # Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.
      SIZE: 902 amino acids; 100810 Da
      SUBUNIT: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with EPB41L1 via its C-terminus (By similarity).
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
      PTM: Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-611 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).
      SIMILARITY: SwissProt: P48058 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.
      MISCELLANEOUS: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.
      Molecular WeightApprox. 100 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by western blot on rat brain lysate.
      Western Blot: Lot Specific Tested Application 1
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8ºC from date of receipt.
      Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Certificados de análisis

      CargoNúmero de lote
      Anti-GluR4 2477000
      Anti-GluR4 - 2398898 2398898
      Anti-GluR4 - 1983963 1983963
      Anti-GluR4 - 2040388 2040388
      Anti-GluR4 - 2070825 2070825
      Anti-GluR4 - 2204911 2204911
      Anti-GluR4 - 2294343 2294343
      Anti-GluR4 - LV1614138 LV1614138
      Anti-GluR4 - LV1679489 LV1679489
      Anti-GluR4 - LV1751777 LV1751777
      Anti-GluR4 - LV1815847 LV1815847
      Anti-GluR4 -2517891 2517891
      Anti-GluR4 -2676628 2676628
      Anti-GluR4 -2688578 2688578

      Referencias bibliográficas | 41 Disponible | Ver todas las referencias

      Visión general referenciasAplicación EspeciePub Med ID
      Neuronal pentraxin 2 supports clear cell renal cell carcinoma by activating the AMPA-selective glutamate receptor-4.
      von Roemeling, CA; Radisky, DC; Marlow, LA; Cooper, SJ; Grebe, SK; Anastasiadis, PZ; Tun, HW; Copland, JA
      Cancer research 74 4796-810 2014

      Mostrar resumen
      24962026 24962026
      Kainate receptors mediate synaptic input to transient and sustained OFF visual pathways in primate retina.
      Puthussery, T; Percival, KA; Venkataramani, S; Gayet-Primo, J; Gr��nert, U; Taylor, WR
      The Journal of neuroscience : the official journal of the Society for Neuroscience 34 7611-21 2014

      Mostrar resumen
      Immunohistochemistry24872565 24872565
      Evidence for glutamate as a neuroglial transmitter within sensory ganglia.
      Kung, LH; Gong, K; Adedoyin, M; Ng, J; Bhargava, A; Ohara, PT; Jasmin, L
      PloS one 8 e68312 2013

      Mostrar resumen
      ImmunohistochemistryRat23844184 23844184
      Pain after discontinuation of morphine treatment is associated with synaptic increase of GluA4-containing AMPAR in the dorsal horn of the spinal cord.
      Caba��ero, D; Baker, A; Zhou, S; Hargett, GL; Irie, T; Xia, Y; Beaudry, H; Gendron, L; Melyan, Z; Carlton, SM; Mor��n, JA
      Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 38 1472-84 2013

      Mostrar resumen
      Western BlottingMouse23403695 23403695
      Amacrine and bipolar inputs to midget and parasol ganglion cells in marmoset retina.
      Carla J Abbott,Kumiko A Percival,Paul R Martin,Ulrike Gr��nert
      Visual neuroscience 29 2012

      Mostrar resumen
      22564345 22564345
      Histamine receptors of cones and horizontal cells in Old World monkey retinas.
      Vila, A; Satoh, H; Rangel, C; Mills, SL; Hoshi, H; O'Brien, J; Marshak, DR; Macleish, PR; Marshak, DW
      The Journal of comparative neurology 520 528-43 2012

      Mostrar resumen
      21800315 21800315
      Quantitative analysis of AMPA receptor subunit composition in addiction-related brain regions.
      Reimers, JM; Milovanovic, M; Wolf, ME
      Brain research 1367 223-33 2011

      Mostrar resumen
      Immunoprecipitation20946890 20946890
      Cell-type-specific localization of protocadherin ��16 at AMPA and AMPAKainate receptor-containing synapses in the primate retina.
      Puller C, Haverkamp S
      J Comp Neurol 519 467-79. 2011

      Mostrar resumen
      21192079 21192079
      Immunohistochemical identification and synaptic inputs to the diffuse bipolar cell type DB1 in macaque retina.
      Puthussery, T; Gayet-Primo, J; Taylor, WR; Haverkamp, S
      The Journal of comparative neurology 519 3640-56 2011

      Mostrar resumen
      22006647 22006647
      Bidirectional plasticity of calcium-permeable AMPA receptors in oligodendrocyte lineage cells.
      Zonouzi, M; Renzi, M; Farrant, M; Cull-Candy, SG
      Nature neuroscience 14 1430-8 2011

      Mostrar resumen
      Western Blotting21983683 21983683

      Ficha técnica

      Cargo
      Anti-Glutamate Receptor 4 - Data Sheet