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393207 | Anti-HNE-Michael Adducts, Reduced Rabbit pAb

393207
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      Descripción

      Replacement Information

      Tabla espec. clave

      Species ReactivityHostAntibody Type
      A Broad Range Of Species Rb Polyclonal Antibody

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1393207-100UL
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      Disponibilidad a confirmarDisponibilidad a confirmar
      En existencia 
      Suspendido
      Cantidades limitadas disponibles
      Debe confirmarse disponibilidad
        El resto: se avisará
          El resto: se avisará
          Se avisará
          Póngase en contacto con el Servicio de Atención al Cliente

          Frasco de vidrio 100 ul
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          Description
          OverviewRecognizes chemically reduced amino acid-(4)-HNE adducts. Does not recognize non-reduced adducts or reduced modifications arising from malondialdehyde (MDA) and structurally-related alkenes such as trans-2-noneal.
          Catalogue Number393207
          Brand Family Calbiochem®
          SynonymsAnti-4-Hydroxy-2-noneal Michael Adducts, Reduced
          References
          ReferencesToyokuni, S., et al. 2000. Antioxid. Redox. Signal 2, 681.
          Neely, M.D., et al. 1999. J. Neurochem. 72, 2323.
          Uchida, K., et al. 1995. Biochem. Biophys. Res. Commun. 212, 1068.
          Uchida, K., et al. 1995. Arch. Biochem. Biophys. 324, 241.
          Uchida, K., et al. 1994. Biochemistry 33, 12487.
          Product Information
          FormLiquid
          FormulationSerum diluted in 50% glycerol, pH 7.5.
          PreservativeNone
          Applications
          Key Applications Enzyme-Linked Immunosorbent Assay
          Frozen Sections
          Immunoblotting (Western Blotting)
          Paraffin Sections
          Application NotesELISA (1:500-1:1000)
          Immunoblotting (1:1000-1:4000)
          Frozen Sections (1:50-1:500)
          Paraffin Sections (1:50-1:500)
          Application CommentsDoes not bind non-reduced adducts and reduced modifications arising from malondialdehyde (MDA) or structurally-related alkenals such as trans-2-noneal. Does not cross-react with non-reduced amino acid-HNE Michael adducts. Antibody binding requires the presence of the 4-hydroxyl group. Variables associated with assay conditions will dictate the optimal working dilution.
          Biological Information
          ImmunogenHNE-treated KLH in which 1:1 amino acid-HNE Michael adducts were chemically reduced
          HostRabbit
          IsotypeIgG
          Species Reactivity
          • A Broad Range Of Species
          Antibody TypePolyclonal Antibody
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          393207

          Referencias bibliográficas

          Visión general referencias
          Toyokuni, S., et al. 2000. Antioxid. Redox. Signal 2, 681.
          Neely, M.D., et al. 1999. J. Neurochem. 72, 2323.
          Uchida, K., et al. 1995. Biochem. Biophys. Res. Commun. 212, 1068.
          Uchida, K., et al. 1995. Arch. Biochem. Biophys. 324, 241.
          Uchida, K., et al. 1994. Biochemistry 33, 12487.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision02-August-2007 RFH
          SynonymsAnti-4-Hydroxy-2-noneal Michael Adducts, Reduced
          ApplicationELISA (1:500-1:1000)
          Immunoblotting (1:1000-1:4000)
          Frozen Sections (1:50-1:500)
          Paraffin Sections (1:50-1:500)
          DescriptionRabbit polyclonal antibody supplied as diluted serum. Recognizes, specifically, chemically reduced amino acid-(4)-HNE adducts.
          BackgroundThe CNS is enriched in polyunsaturated fatty acids and is therefore particularly vulnerable to lipid peroxidation. 4-Hydroxy-2-noneal (HNE) is one of the major lipid peroxidation products with cytotoxic and mutagenic activity. It reacts with protein residues such as histidine to generate stable Michael adducts. HNE has been shown to inhibit neurite outgrowth and disrupt microtubules and tubulin modification, suggesting it may play a role in Alzheimer's disease.
          HostRabbit
          ImmunogenHNE-treated KLH in which 1:1 amino acid-HNE Michael adducts were chemically reduced
          IsotypeIgG
          Speciesa broad range of species
          FormLiquid
          FormulationSerum diluted in 50% glycerol, pH 7.5.
          PreservativeNone
          CommentsDoes not bind non-reduced adducts and reduced modifications arising from malondialdehyde (MDA) or structurally-related alkenals such as trans-2-noneal. Does not cross-react with non-reduced amino acid-HNE Michael adducts. Antibody binding requires the presence of the 4-hydroxyl group. Variables associated with assay conditions will dictate the optimal working dilution.
          Storage ≤ -70°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Toxicity Standard Handling
          ReferencesToyokuni, S., et al. 2000. Antioxid. Redox. Signal 2, 681.
          Neely, M.D., et al. 1999. J. Neurochem. 72, 2323.
          Uchida, K., et al. 1995. Biochem. Biophys. Res. Commun. 212, 1068.
          Uchida, K., et al. 1995. Arch. Biochem. Biophys. 324, 241.
          Uchida, K., et al. 1994. Biochemistry 33, 12487.