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MAB1956 | Anti-Integrin α5 Antibody, clone P1D6

MAB1956
100 µL  
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      Descripción

      Replacement Information

      Ofertas especiales

      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H IHC, FUNC M Ascites Monoclonal Antibody
      Description
      Catalogue NumberMAB1956
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Integrin α5 Antibody, clone P1D6
      Alternate Names
      • CD49e
      References
      Product Information
      FormatAscites
      Control
      • Widely expressed, ovary
      PresentationUnPurified scites containing no preservatives.
      Applications
      ApplicationAnti-Integrin α5 Antibody, clone P1D6 is an antibody against Integrin α5 for use in IH.
      Key Applications
      • Immunohistochemistry
      • Affects Function
      Application NotesMAB1956 is suitable for use in attachment inhibition assays using fibroblasts, endothelial cells, platelets and T & B lymphocytes on fibronectin.

      MAB1956 is not reactive with the denatured alpha 5 subunit. For immunoblotting, a dot blot is suggested as an alternative to western blotting.
      Biological Information
      CloneP1D6
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityReacts with Human alpha 5 integrin. Reactivity with other species is unknown.
      IsotypeIgG3
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
      Gene Symbol
      • ITGA5
      • VLA-5
      • CD49e
      • VLA5A
      • FNRA
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P08648 # Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
      SIZE: 1049 amino acids; 114536 Da
      SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5. Interacts with HIV-1 Tat.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      SIMILARITY: SwissProt: P08648 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Certificados de análisis

      CargoNúmero de lote
      MOUSE ANTI-HUMAN INTEGRIN alpha 5 MONOCLONAL ANTIBODY - 2384716 2384716
      MOUSE ANTI-HUMAN INTEGRIN alpha 5 -2517769 2517769
      MOUSE ANTI-HUMAN INTEGRIN alpha 5 -2770802 2770802
      MOUSE ANTI-HUMAN INTEGRIN alpha 5 MONOCLONAL ANTIBODY - 2136622 2136622

      Referencias bibliográficas | 12 Disponible | Ver todas las referencias

      Visión general referenciasPub Med ID
      Using Self-Assembled Monolayers To Understand α8β1- Mediated Cell Adhesion to RGD and FEI Motifs in Nephronectin.
      Sánchez-Cortés J, Mrksich M
      ACS chemical biology 6 1078-86. Epub 2011 Aug 12. 2011

      Mostrar resumen Artículo Texto completo
      21790180 21790180
      Mechanical regulation of proteoglycan synthesis in normal and osteoarthritic human articular chondrocytes--roles for alpha5 and alphaVbeta5 integrins.
      M Maruo Holledge,S J Millward-Sadler,G Nuki,D M Salter
      Biorheology 45 2008

      Mostrar resumen
      18836230 18836230
      Integrin alpha2-mediated ERK and calpain activation play a critical role in cell adhesion and motility via focal adhesion kinase signaling: identification of a novel signaling pathway
      Sawhney, Rajinder S, et al
      J Biol Chem, 281:8497-510 (2006) 2006

      16461767 16461767
      Design of a novel fibronectin-mimetic peptide-amphiphile for functionalized biomaterials.
      Mardilovich, Anastasia, et al.
      Langmuir : the ACS journal of surfaces and colloids, 22: 3259-64 (2006) 2006

      Mostrar resumen
      16548586 16548586
      Beta1-integrins mediate enhancement of human airway smooth muscle proliferation by collagen and fibronectin
      Nguyen TTB, Ward JPT and Hirst SJ.
      Am J Resp Crit Care Med. , 171(3):217-223 (2005) 2005

      15502110 15502110
      Integrins modulate fast excitatory transmission at hippocampal synapses.
      Kramár, EA; Bernard, JA; Gall, CM; Lynch, G
      The Journal of biological chemistry 278 10722-30 2003

      Mostrar resumen
      12524441 12524441
      Developmental and regional differences in the consolidation of long-term potentiation.
      E A Kramár, G Lynch
      Neuroscience 118 387-98 2003

      Mostrar resumen
      12699775 12699775
      Mutations in the heparin binding domain of fibronectin in cooperation with the V region induce decreases in pp125(FAK) levels plus proteoglycan-mediated apoptosis via caspases.
      Kapila, Y L, et al.
      J. Biol. Chem., 274: 30906-13 (1999) 1999

      Mostrar resumen
      10521484 10521484
      Fibronectin fragments modulate monocyte VLA-5 expression and monocyte migration.
      Trial, J; Baughn, RE; Wygant, JN; McIntyre, BW; Birdsall, HH; Youker, KA; Evans, A; Entman, ML; Rossen, RD
      The Journal of clinical investigation 104 419-30 1999

      Mostrar resumen
      10449434 10449434
      Regulation of integrin function: evidence that bivalent-cation-induced conformational changes lead to the unmasking of ligand-binding sites within integrin alpha5 beta1.
      Mould, A P, et al.
      Biochem. J., 331 ( Pt 3): 821-8 (1998) 1998

      Mostrar resumen
      9560310 9560310

      Ficha técnica

      Cargo
      Anti-Integrin alpha5, clone P1D6 - Data Sheet

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      Categorías

      Life Science Research > Antibodies and Assays > Primary Antibodies