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AB1431 | Anti-Interferon-β Antibody

AB1431
20000 units  
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      Descripción

      Replacement Information

      Ofertas especiales

      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H ELISA, IHC, IP, NEUT, WB Rb Serum Polyclonal Antibody
      Description
      Catalogue NumberAB1431
      Replaces04-1095
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Interferon-β Antibody
      Alternate Names
      • IFN-beta
      Background InformationInterferon beta is a globular protein consisting of 5 alpha helices with a predicted molecular weight of 20 kDa. Due to glycosylation, however, the observed molecular weight is closer to 25 kDa by SDS-PAGE.
      References
      Product Information
      FormatSerum
      Control
      • IFN expressing cell lines
      PresentationRabbit Serum diluited with PBS. Liquid containing no preservatives.
      Applications
      ApplicationThis Anti-Interferon-β Antibody is validated for use in ELISA, IH, IP, NEUT, WB for the detection of Interferon-β.
      Key Applications
      • ELISA
      • Immunohistochemistry
      • Immunoprecipitation
      • Neutralizing
      • Western Blotting
      Application NotesInterferon neutralization: 2 x 10e5 neutralization units/mL where one neutralization unit is the amount of antiserum required to neutralize one unit of human interferon beta (Hu-IFN-b) to a 50% endpoint. Interferon was titrated with the use of the cytopathic effect inhibition assay as described [Rubinstein, S., Familletti, P.C., and Pestka, S. (1981) "Convenient Assay for Interferons," in J. Virol., Vol. 37, 755-758]; [Familletti, P.C., Rubinstein, S., and Pestka, S. (1981) "A Convenient and Rapid Cytopathic Effect Inhibition Assay for Interferon," in Methods of Enzymology, Vol. 78 (S. Pestka, ed.), Academic Press, New York, 387-394]. In this antiviral assay for interferon about 1 unit/mL of interferon is the quantity necessary to produce a cytopathic effect of 50%. The units are determined with respect to the international reference standard for human interferon beta provided by the National Institutes of Health [see Pestka, S. (1986) "Interferon Standards and General Abbreviations," in Methods in Enzymology (S. Pestka, ed.), Academic Press, New York 119, 14-23]. This material is prepared specifically for the effective neutralization of human interferon beta.

      Immunohistochemistry

      Western blot: 1:5000

      Immunoprecipitation

      ELISA

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenRecombinant human interferon beta expressed in E. coli
      HostRabbit
      SpecificityRecognizes Human interferon beta.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • IL6
      • HSF
      • BSF-2
      • HGF
      • IL-6
      • BSF2
      • CDF
      • IFNB2
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P05231 # IL-6 is a cytokine with a wide variety of biological functions: it plays an essential role in the final differentiation of B-cells into Ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants.
      SIZE: 212 amino acids; 23718 Da
      SUBCELLULAR LOCATION: Secreted.
      PTM: N- and O-glycosylated.
      DISEASE: SwissProt: P05231 # Genetic variations in IL6 are associated with susceptibility to systemic juvenile rheumatoid arthritis [MIM:604302]. Systemic juvenile rheumatoid arthritis is juvenile chronic arthritis associated with severe, debilitating, extraarticular features, and occasionally fatal complications. Despite medical treatment, many children still experience early joint destruction, necessitating surgical replacement. & At least 1 polymorphism in the IL6 gene renders HIV- infected men susceptible to Kaposi sarcoma [MIM:148000]. Kaposi sarcoma is a sarcoma of spindle cells mixed with angiomatous tissue. A relatively rare malignant skin tumor that results in multifocal purplish coloured papules or plaques that eventually form nodules. Most commonly seen in patients who suffer from AIDS.
      SIMILARITY: SwissProt: P05231 ## Belongs to the IL-6 superfamily.
      Molecular Weight20 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size20000 units
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Certificados de análisis

      CargoNúmero de lote
      RABBIT ANTI-HUMAN INTERFERON BETA 2458939
      RABBIT ANTI-HUMAN INTERFERON BETA POLYCLONAL ANTIBODY - 2145051 2145051
      RABBIT ANTI-HUMAN INTERFERON BETA POLYCLONAL ANTIBODY - 2384629 2384629
      RABBIT ANTI-HUMAN INTERFERON BETA -2582482 2582482
      RABBIT ANTI-HUMAN INTERFERON BETA -2590158 2590158
      RABBIT ANTI-HUMAN INTERFERON BETA -2590853 2590853
      RABBIT ANTI-HUMAN INTERFERON BETA -2607281 2607281
      RABBIT ANTI-HUMAN INTERFERON BETA -2610970 2610970
      RABBIT ANTI-HUMAN INTERFERON BETA -2691390 2691390
      RABBIT ANTI-HUMAN INTERFERON BETA -2698373 2698373
      RABBIT ANTI-HUMAN INTERFERON BETA -2707285 2707285
      RABBIT ANTI-HUMAN INTERFERON BETA -2721500 2721500
      RABBIT ANTI-HUMAN INTERFERON BETA -2726159 2726159
      RABBIT ANTI-HUMAN INTERFERON BETA POLYCLONAL ANTIBODY - 2005906 2005906
      RABBIT ANTI-HUMAN INTERFERON BETA POLYCLONAL ANTIBODY - 2018049 2018049
      RABBIT ANTI-HUMAN INTERFERON BETA POLYCLONAL ANTIBODY - 2048764 2048764
      RABBIT ANTI-HUMAN INTERFERON BETA POLYCLONAL ANTIBODY - 2327991 2327991
      RABBIT ANTI-HUMAN INTERFERON BETA POLYCLONAL ANTIBODY - 2752739 2752739
      RABBIT ANTI-HUMAN INTERFERON BETA POLYCLONAL ANTIBODY -2483155 2483155
      RABBIT ANTI-HUMAN INTERFERON BETA POLYCLONAL ANTIBODY -2488761 2488761
      RABBIT ANTI-HUMAN INTERFERON BETA POLYCLONAL ANTIBODY -2844127 2844127
      RABBIT ANTI-HUMAN INTERFERON BETA_2839793 2839793

      Referencias bibliográficas

      Visión general referenciasAplicación Pub Med ID
      The mef/elf4 transcription factor fine tunes the DNA damage response.
      Sashida, G; Bae, N; Di Giandomenico, S; Asai, T; Gurvich, N; Bazzoli, E; Liu, Y; Huang, G; Zhao, X; Menendez, S; Nimer, SD
      Cancer research 71 4857-65 2011

      Mostrar resumen
      21616937 21616937
      A hyperfusogenic F protein enhances the oncolytic potency of a paramyxovirus simian virus 5 P/V mutant without compromising sensitivity to type I interferon.
      Gainey, MD; Manuse, MJ; Parks, GD
      Journal of virology 82 9369-80 2008

      Mostrar resumen Artículo Texto completo
      18667520 18667520
      A human cytomegalovirus antagonist of type I IFN-dependent signal transducer and activator of transcription signaling.
      Paulus, C; Krauss, S; Nevels, M
      Proceedings of the National Academy of Sciences of the United States of America 103 3840-5 2006

      Mostrar resumen Artículo Texto completo
      Immunoprecipitation16497831 16497831
      Convenient assay for interferons.
      Rubinstein, S, et al.
      J. Virol., 37: 755-8 (1981) 1981

      Mostrar resumen
      6163873 6163873

      Ficha técnica

      Cargo
      RABBIT ANTI-HUMAN INTERFERON BETA POLYCLONAL ANTIBODY