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AB5066P | Anti-Norepinephrine Transporter Antibody

AB5066P
50 µg  
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      Replacement Information

      Ofertas especiales

      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, R ELISA, WB Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberAB5066P
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Norepinephrine Transporter Antibody
      Alternate Names
      • NET
      References
      Product Information
      FormatAffinity Purified
      Control
      • Brain tissue
      PresentationAffinity Purified immunoglobulin. Liquid in PBS with 0.1% BSA .
      Applications
      ApplicationThis Anti-Norepinephrine Transporter Antibody is validated for use in ELISA, WB for the detection of Norepinephrine Transporter.
      Key Applications
      • ELISA
      • Western Blotting
      Application NotesWestern blot: 1-10 μg/mL (Chemiluminescence technique): NET can exist is at least two forms, a highly glycosylated ~80kDa form is the most common in brain, and a lessly glycosylated 54kDa form is also seen in some regions and tissues.



      ELISA: 1:10,000-1:100,000 (50-100 ng immunogen peptide/well) Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenA 22 amino acid peptide sequence mapping to the 1st extracellular domain of rat NET.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificitySpecific for Norepinephrine Transporter (NET). Norepinephrine Transporter is a 617 amino acid long integral membrane protein belonging to the Sodium:Neurotransmitter Symporter family (Bruss et al. 1995; Melikian et al. 1994; Pacholczyk et al. 1991) The immunogen peptide shows no significant homology with other other known proteins.
      Species Reactivity
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe SLC6A2 gene encodes a norepinephrine (noradrenaline) transporter, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis (Kim et al., 2006 [PubMed 17146058]).[supplied by OMIM]
      Gene Symbol
      • SLC6A2
      • NAT1
      • NET
      • SLC6A5
      • NET1
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P23975 # Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.
      SIZE: 617 amino acids; 69332 Da
      SUBUNIT: Interacts with PRKCABP.
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      DISEASE: SwissProt: P23975 # Defects in SLC6A2 are a cause of orthostatic intolerance (OI) [MIM:604715]. OI is a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. It is associated with postural tachycardia. Plasma norepinephrine concentration is abnormally high.
      SIMILARITY: SwissProt: P23975 ## Belongs to the sodium:neurotransmitter symporter (SNF) family.
      MISCELLANEOUS: This protein is the target of psychomotor stimulants such as amphetamines or cocaine.
      Molecular Weight80 & 54 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Certificados de análisis

      CargoNúmero de lote
      AB5066PRABBIT ANTI-RAT NOREPINEPHRINE TRANSPORTER (NET) AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2033632 2033632
      RABBIT ANTI-RAT NOREPINEPHRINE TRANSPORTER (NET) AFFINITY PURIFIED POLYCLONAL ANTIBODY - 1984659 1984659
      RABBIT ANTI-RAT NOREPINEPHRINE TRANSPORTER (NET) AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2010068 2010068
      RABBIT ANTI-RAT NOREPINEPHRINE TRANSPORTER (NET) AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2054790 2054790
      RABBIT ANTI-RAT NOREPINEPHRINE TRANSPORTER (NET) AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2063147 2063147
      RABBIT ANTI-RAT NOREPINEPHRINE TRANSPORTER (NET) AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2274032 2274032
      RABBIT ANTI-RAT NOREPINEPHRINE TRANSPORTER (NET) AFFINITY PURIFIED POLYCLONAL ANTIBODY -2567109 2567109
      RABBIT ANTI-RAT NOREPINEPHRINE TRANSPORTER (NET) AFFINITY PURIFIED POLYCLONAL ANTIBODY -2757092 2757092
      RABBIT ANTI-RAT NOREPINEPHRINE TRANSPORTER (NET) AFFINITY PURIFIED POLYCLONAL ANTIBODY -2789722 2789722

      Referencias bibliográficas

      Visión general referenciasAplicación EspeciePub Med ID
      The mouse olfactory peduncle. 2.The anterior limb of the anterior commissure.
      Brunjes, PC
      Frontiers in neuroanatomy 6 51 2012

      Mostrar resumen
      ImmunohistochemistryMouse23355812 23355812
      Expression and distribution of dopamine transporter in cardiac tissues of the guinea pig.
      Alejandro Reynoso Palomar,Berenice Navarrete Larios,Victoria Chagoya De Sánchez,Lidia Martínez Pérez,Fidel De La Cruz López,Gonzalo Flores,Maria de Jesús Gómez-Villalobos
      Neurochemical research 36 2011

      Mostrar resumen
      21170736 21170736
      Sympathetic nervous dysregulation in the absence of systolic left ventricular dysfunction in a rat model of insulin resistance with hyperglycemia.
      Thackeray, JT; Radziuk, J; Harper, ME; Suuronen, EJ; Ascah, KJ; Beanlands, RS; Dasilva, JN
      Cardiovascular diabetology 10 75 2011

      Mostrar resumen
      21831292 21831292
      Neurotoxic catecholamine metabolite in nociceptors contributes to painful peripheral neuropathy.
      Olayinka A Dina, Sachia G Khasar, Nicole Alessandri-Haber, Oliver Bogen, Xiaojie Chen, Paul G Green, David B Reichling, Robert O Messing, Jon D Levine, Olayinka A Dina, Sachia G Khasar, Nicole Alessandri-Haber, Oliver Bogen, Xiaojie Chen, Paul G Green, David B Reichling, Robert O Messing, Jon D Levine, Olayinka A Dina, Sachia G Khasar, Nicole Alessandri-Haber, Oliver Bogen, Xiaojie Chen, Paul G Green, David B Reichling, Robert O Messing, Jon D Levine, Olayinka A Dina, Sachia G Khasar, Nicole Alessandri-Haber, Oliver Bogen, Xiaojie Chen, Paul G Green, David B Reichling, Robert O Messing, Jon D Levine
      The European journal of neuroscience 28 1180-90 2008

      Mostrar resumen Artículo Texto completo
      18783367 18783367
      Effects of chronic unpredictable stress on monoamine transporter immunoreactivity and methamphetamine-induced dopamine release in the nucleus accumbens shell.
      Jamie Raudensky, Bryan K Yamamoto
      Synapse (New York, N.Y.) 61 353-5 2007

      17318887 17318887
      Functional coupling of serotonin and noradrenaline transporters.
      Sandra Horschitz, René Hummerich, Patrick Schloss
      Journal of neurochemistry 86 958-65 2003

      Mostrar resumen
      12887693 12887693
      Protein kinase C and intracellular calcium are required for amphetamine-mediated dopamine release via the norepinephrine transporter in undifferentiated PC12 cells.
      Kantor, L, et al.
      J. Pharmacol. Exp. Ther., 297: 1016-24 (2001) 2001

      Mostrar resumen
      11356924 11356924
      Functional characterization of the splicing variants of human norepinephrine transporter.
      S Kitayama, K Morita, T Dohi
      Neuroscience letters 312 108-12 2001

      Mostrar resumen
      11595346 11595346
      Antipeptide antibodies confirm the topology of the human norepinephrine transporter.
      Brüss, M, et al.
      J. Biol. Chem., 270: 9197-201 (1995) 1995

      7721836 7721836
      Human norepinephrine transporter. Biosynthetic studies using a site-directed polyclonal antibody.
      Melikian, H E, et al.
      J. Biol. Chem., 269: 12290-7 (1994) 1994

      Mostrar resumen
      8163533 8163533

      Ficha técnica

      Cargo
      RABBIT ANTI-RAT NOREPINEPHRINE TRANSPORTER (NET) AFFINITY PURIFIED POLYCLONAL ANTIBODY