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07-524 | Anti-Spry2 Antibody

200 µg  
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      Replacement Information

      Ofertas especiales

      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R WB Rb Purified Polyclonal Antibody
      Catalogue Number07-524
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Spry2 Antibody
      Product Information
      • Positive Control Included: 3T3 Cell Lysate (12-305)
      PresentationProtein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
      ApplicationDetect Spry2 using this Anti-Spry2 Antibody validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenPeptide corresponding to amino acids 26-39 of human SPROUTY2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityRecognizes SPROUTY2.
      Species Reactivity
      • Human
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.
      Gene Symbol
      • SPRY2
      • hSPRY2
      • Spry-2
      • MGC23039
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O43597 # May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.
      SIZE: 315 amino acids; 34688 Da
      SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Note=Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated ith EGF (epidermal growth factor).
      DOMAIN: SwissProt: O43597 The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.
      SIMILARITY: Belongs to the sprouty family. & Contains 1 SPR (sprouty) domain.
      Molecular Weight35-40 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot in in RIPA lysates from HeLa and 3T3/A31
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information


      Ficha datos de seguridad (MSDS)


      Ficha técnica de seguridad del material (MSDS) 

      Certificados de análisis

      CargoNúmero de lote
      Anti-Spry2 (rabbit polyclonal IgG) - 2344655 2344655
      Anti-Spry2 (rabbit polyclonal IgG) - 2273957 2273957
      Anti-Spry2 - 24668 24668
      Anti-Spry2 - 31940 31940
      Anti-Spry2 -2607732 2607732
      Anti-Spry2 -2679371 2679371
      Anti-Spry2 -2700838 2700838
      AntiAnti -Spry2 -2792487 2792487

      Referencias bibliográficas

      Visión general referenciasAplicación EspeciePub Med ID
      Expression and functional role of sprouty-2 in breast morphogenesis.
      Sigurdsson, V; Ingthorsson, S; Hilmarsdottir, B; Gustafsdottir, SM; Franzdottir, SR; Arason, AJ; Steingrimsson, E; Magnusson, MK; Gudjonsson, T
      PloS one 8 e60798 2013

      Mostrar resumen
      ImmunohistochemistryHuman, Mouse23573284 23573284
      A novel cross-talk between endothelin and ErbB receptors controlling glutamate transporter expression in astrocytes.
      Darko Glisic,Claudia Lehmann,Maciej Figiel,Veysel Odemis,Ricco Lindner,Jürgen Engele,Veysel ,J Engele
      Journal of neurochemistry 122 2012

      Mostrar resumen
      22671705 22671705
      Cathespin H is an Fgf10 target involved in Bmp4 degradation during lung branching morphogenesis.
      Lü, J; Qian, J; Keppler, D; Cardoso, WV
      The Journal of biological chemistry 282 22176-84 2007

      Mostrar resumen
      17500053 17500053
      Concomitant down-regulation of SPRY1 and SPRY2 in prostate carcinoma.
      Fritzsche, S; Kenzelmann, M; Hoffmann, MJ; Müller, M; Engers, R; Gröne, HJ; Schulz, WA
      Endocrine-related cancer 13 839-49 2006

      Mostrar resumen
      16954433 16954433
      Sprouty2 inhibits the Ras/MAP kinase pathway by inhibiting the activation of Raf.
      Yusoff, Permeen, et al.
      J. Biol. Chem., 277: 3195-201 (2002) 2002

      Mostrar resumen
      11698404 11698404
      Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.
      Hanafusa, Hiroshi, et al.
      Nat. Cell Biol., 4: 850-8 (2002) 2002

      Mostrar resumen
      12402043 12402043
      sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways.
      Hacohen, N, et al.
      Cell, 92: 253-63 (1998) 1998

      Mostrar resumen
      9458049 9458049

      Productos y aplicaciones relacionados

      Included Positive Control

      Número de referencia Descripción  
      12-305 3T3/A31 Cell Lysate Precios y disponibilidad

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      Life Science Research > Antibodies and Assays > Primary Antibodies