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203671 | Bongkrekic Acid, Triammonium Salt - CAS 1177154-51-6 - Calbiochem

203671
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical FormulaCAS #
      C₂₈H₃₅O₇ · 3NH₄ 1177154-51-6

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1203671-500UG
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      Disponibilidad a confirmarDisponibilidad a confirmar
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          Frasco de vidrio 500 μg
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          Description
          OverviewActs as a ligand of the adenine nucleotide translocator. A potent inhibitor of mitochondrial megachannel (permeability transition pore). Significantly reduces signs of apoptosis induced by nitric oxide. Prevents the apoptotic breakdown of the inner mitochondrial transmembrane potential (ΔΨm), as well as a number of other phenomena linked to apoptosis.
          Catalogue Number203671
          Brand Family Calbiochem®
          Synonyms3-Carboxymethyl-17-methoxy-6,18,21-trimethyldocosa-2,4,8,12,18,20-heptaenedioic Acid, BA, 3NH₄
          References
          ReferencesHirsch, T., et al. 1998. J. Immunol. 161, 35.
          Horteleno, S., et al. 1997. FEBS Lett. 410, 373.
          Marchetti, P., et al. 1996. J. Exp. Med. 184, 1155.
          Marchetti, P., et al. 1996. J. Immunol. 157, 4830.
          Zamzami, N., et al. 1996. J. Exp. Med. 183, 1533.
          Henderson, P.J., and Lardy, H.A. 1970. J. Biol. Chem. 245, 1319.
          Product Information
          CAS number1177154-51-6
          ATP CompetitiveN
          FormBeige-pink solid
          Hill FormulaC₂₈H₃₅O₇ · 3NH₄
          Chemical formulaC₂₈H₃₅O₇ · 3NH₄
          ReversibleN
          Structure formula Image
          Applications
          ApplicationBongkrekic Acid, Triammonium Salt, CAS 1177154-51-6, acts as a ligand of the adenine nucleotide translocator. A potent inhibitor of mitochondrial megachannel (permeability transition pore).
          Biological Information
          Primary TargetMitochondrial mega channel
          Purity≥92% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 20/21/22-40

          Harmful by inhalation, in contact with skin and if swallowed.
          Limited evidence of a carcinogenic effect.
          S PhraseS: 36-22

          Wear suitable protective clothing.
          Do not breathe dust.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Harmful & Carcinogenic / Teratogenic
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          203671

          Referencias bibliográficas

          Visión general referencias
          Hirsch, T., et al. 1998. J. Immunol. 161, 35.
          Horteleno, S., et al. 1997. FEBS Lett. 410, 373.
          Marchetti, P., et al. 1996. J. Exp. Med. 184, 1155.
          Marchetti, P., et al. 1996. J. Immunol. 157, 4830.
          Zamzami, N., et al. 1996. J. Exp. Med. 183, 1533.
          Henderson, P.J., and Lardy, H.A. 1970. J. Biol. Chem. 245, 1319.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision24-June-2011 JSW
          Synonyms3-Carboxymethyl-17-methoxy-6,18,21-trimethyldocosa-2,4,8,12,18,20-heptaenedioic Acid, BA, 3NH₄
          DescriptionActs as a ligand of the adenine nucleotide translocator. A potent inhibitor of mitochondrial megachannel (permeability transition pore). Significantly reduces signs of apoptosis induced by nitric oxide. Prevents the apoptotic breakdown of the inner mitochondrial transmembrane potential (ΔΨm), as well as a number of other phenomena linked to apoptosis.
          FormBeige-pink solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1177154-51-6
          Chemical formulaC₂₈H₃₅O₇ · 3NH₄
          Structure formula
          Purity≥92% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
          Toxicity Harmful & Carcinogenic / Teratogenic
          Merck USA index14, 1332
          ReferencesHirsch, T., et al. 1998. J. Immunol. 161, 35.
          Horteleno, S., et al. 1997. FEBS Lett. 410, 373.
          Marchetti, P., et al. 1996. J. Exp. Med. 184, 1155.
          Marchetti, P., et al. 1996. J. Immunol. 157, 4830.
          Zamzami, N., et al. 1996. J. Exp. Med. 183, 1533.
          Henderson, P.J., and Lardy, H.A. 1970. J. Biol. Chem. 245, 1319.