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GF029 | Brain Derived Neurotrophic Factor, recombinant

GF029
10 µg  
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      Descripción

      Replacement Information

      Tabla espec. clave

      SpeciesSourcePurity
      Human E. coli Greater than 98% by SDS-PAGE and HPLC analyses. Endotoxin level is less than 0.1 ng per μg (1EU/μg) of BDNF.
      Description
      Catalogue NumberGF029
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionBrain Derived Neurotrophic Factor, recombinant
      OverviewBDNF is a potent neurotrophic factor which supports the growth and survivability of nerve and/or glial cells. The active form of human BDNF is a 27.0 kDa dimer, formed by two identical 119 amino acid subunits, which is held together by strong hydrophobic interactions.
      Alternate Names
      • BDNF
      References
      Product Information
      PresentationSterile filtered, lyophilized with no additives.
      Applications
      ApplicationThe recombinant BDNF protein is a potent neurotrophic factor which supports the growth & survivability of nerve and/or glial cells.
      Application NotesConcentration range for most in vitro applications is 0.5 to 100 ng/mL. Responding cells are (partial list): Nerve, glial cells.
      Biological Information
      PurityGreater than 98% by SDS-PAGE and HPLC analyses. Endotoxin level is less than 0.1 ng per μg (1EU/μg) of BDNF.
      SourceE. coli
      Specific ActivityChemicon's human BDNF is fully biologically active when compared to standards. The ED50 as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cultures was found to be 25-50 ng/mL. The ED50 as determined by its availability to stimulate chick E8 neurite outgrowth was found to be 0.1-1.0 ng/mL
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene, but the full-length nature of only some could be determined.
      Gene Symbol
      • BDNF
      • Abrineurin
      • neurotrophin
      • MGC34632
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P23560 # Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
      SIZE: 247 amino acids; 27818 Da
      SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB.
      SUBCELLULAR LOCATION: Secreted.
      PTM: The propeptide is N-glycosylated and glycosulfated. & Converted into mature BDNF by plasmin (PLG) (By similarity).
      DISEASE: SwissProt: P23560 # Defects in BDNF are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. CCHS is frequently complicated with neurocristopathies such as Hirschsprung disease that occurs in about 16% of CCHS cases.
      SIMILARITY: SwissProt: P23560 ## Belongs to the NGF-beta family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsThe lyophilized powder, though stable at room temperature, is best stored desiccated below 0°C. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can be diluted into water or other buffered solutions. Reconstituted BDNF should be stored in undiluted aliquots at -20°C for up to six months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Certificados de análisis

      CargoNúmero de lote
      RECOMBINANT HUMAN BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) - 2387400 2387400
      RECOMBINANT HUMAN BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) - 2388832 2388832
      RECOMBINANT HUMAN BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) - 2430331 2430331
      RECOMBINANT HUMAN BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) - 1996976 1996976
      RECOMBINANT HUMAN BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) - 2049781 2049781
      RECOMBINANT HUMAN BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) - 2070391 2070391
      RECOMBINANT HUMAN BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) - 2239590 2239590
      RECOMBINANT HUMAN BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) -2491107 2491107
      RECOMBINANT HUMAN BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) -2519300 2519300
      RECOMBINANT HUMAN BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) -2572981 2572981
      RECOMBINANT HUMAN BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) -2581776 2581776
      RECOMBINANT HUMAN BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) -2661370 2661370
      RECOMBINANT HUMAN BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) -2698435 2698435
      RECOMBINANT HUMAN BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) -2709706 2709706
      RECOMBINANT HUMAN BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) -2718363 2718363
      Recombinant Human Brain Derived Neurotropic Factor 2462763

      Referencias bibliográficas

      Visión general referenciasPub Med ID
      Learning induces neurotrophin signaling at hippocampal synapses.
      Lulu Y Chen,Christopher S Rex,Yas Sanaiha,Gary Lynch,Christine M Gall
      Proceedings of the National Academy of Sciences of the United States of America 107 2010

      Mostrar resumen Artículo Texto completo
      20356829 20356829
      Nicotinic alpha 7 receptor clusters on hippocampal GABAergic neurons: regulation by synaptic activity and neurotrophins.
      Kawai, Hideki, et al.
      J. Neurosci., 22: 7903-12 (2002) 2002

      Mostrar resumen
      12223543 12223543

      Ficha técnica

      Cargo
      RECOMBINANT HUMAN BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF)

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      Categorías

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors