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344550 | FTI-276 - Calbiochem

344550
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical Formula
      C₂₁H₂₇N₃O₃S₂

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1344550-250UG
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      Disponibilidad a confirmarDisponibilidad a confirmar
      En existencia 
      Suspendido
      Cantidades limitadas disponibles
      Debe confirmarse disponibilidad
        El resto: se avisará
          El resto: se avisará
          Se avisará
          Póngase en contacto con el Servicio de Atención al Cliente

          Frasco de vidrio 250 μg
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          Description
          OverviewA highly potent and selective CAAX peptidomimetic of the carboxyl terminal of Ras proteins that inhibits farnesyl transferase (FTase) in vitro (IC50 = 500 pM). Inhibits geranylgeranyltransferase I (GGTase I) at much higher concentration (IC50 = 50 nM). Has been shown to selectively block the growth of a human lung carcinoma expressing oncogenic K-Ras in nude mice. Also inhibits oncogenic signaling and tumor growth of NIH 3T3 cells transformed with the Ras oncogene at 20 µM.
          Catalogue Number344550
          Brand Family Calbiochem®
          SynonymsN-[2-phenyl-4-N[2(R)-amino-3-mercaptopropylamino benzoyl]-methionine, TFA
          References
          ReferencesLantry, L.E., et al. 2000. Carcinogenesis 21, 113.
          Lerner, E.C., et al. 1995. J. Biol. Chem. 270, 26802.
          Sun, J., et al. 1995. Cancer Res. 55, 4243.
          Product Information
          ATP CompetitiveN
          FormWhite solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₂₁H₂₇N₃O₃S₂
          Chemical formulaC₂₁H₂₇N₃O₃S₂
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula Image
          Applications
          Biological Information
          Primary TargetFTase in vitro
          Primary Target IC<sub>50</sub>500 pM against FTase in vitro
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 1 week at -70°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          344550

          Referencias bibliográficas

          Visión general referencias
          Lantry, L.E., et al. 2000. Carcinogenesis 21, 113.
          Lerner, E.C., et al. 1995. J. Biol. Chem. 270, 26802.
          Sun, J., et al. 1995. Cancer Res. 55, 4243.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-June-2008 RFH
          SynonymsN-[2-phenyl-4-N[2(R)-amino-3-mercaptopropylamino benzoyl]-methionine, TFA
          DescriptionA highly potent and selective CAAX peptidomimetic of the carboxyl terminal of Ras proteins that inhibits farnesyl transferase (FTase) in vitro (IC50 = 500 pM). Inhibits geranylgeranyltransferase I (GGTase I) at much higher concentration (IC50 = 50 nM). Has been shown to selectively block the growth of a human lung carcinoma expressing oncogenic K-Ras in nude mice. Also inhibits oncogenic signaling and tumor growth of NIH 3T3 cells transformed with the Ras oncogene at 20 µM.
          FormWhite solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₁H₂₇N₃O₃S₂
          Structure formula
          Purity≥90% by HPLC
          SolubilityDMSO (25 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 1 week at -70°C.
          Toxicity Standard Handling
          ReferencesLantry, L.E., et al. 2000. Carcinogenesis 21, 113.
          Lerner, E.C., et al. 1995. J. Biol. Chem. 270, 26802.
          Sun, J., et al. 1995. Cancer Res. 55, 4243.