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361550 | GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem

361550
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical FormulaCAS #
      C₁₆H₁₀BrN₃O₂ 667463-62-9

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1361550-1MG
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      Disponibilidad a confirmarDisponibilidad a confirmar
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      Debe confirmarse disponibilidad
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          Description
          OverviewA cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC50 = 5 nM). Its specificity has been tested against various Cdk's (IC50 = 83, 300, 320, and 10,000 nM for Cdk5/p25, Cdk2/A, Cdk1/B, and Cdk4/D1, respectively) as well as many other commonly studied kinases (IC50 ≥ 10 µM), including MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK. Inhibition of GSK by BIO has been shown to result in the activation of Wnt-signaling pathway and sustained pluripotency in human and murine ESCs (embryonic stem cells). Reported to maintain self-renewal in human and mouse embryonic stem cells. Also induces the differentiation of neonatal cardiomyocytes. A 10 mM (500 µg/140 µl) solution of GSK-3 Inhibitor IX (Cat. No. 361552) in DMSO is also available.
          Catalogue Number361550
          Brand Family Calbiochem®
          SynonymsBIO, (2ʹZ,3ʹE)-6-Bromoindirubin-3ʹ-oxime
          References
          ReferencesTseng, A-S., et al. 2006. Chem. Biol. 13, 957.
          Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
          Sato, N., et al. 2004. Nat. Med. 10, 55.
          Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
          Product Information
          CAS number667463-62-9
          ATP CompetitiveY
          FormPurple solid
          Hill FormulaC₁₆H₁₀BrN₃O₂
          Chemical formulaC₁₆H₁₀BrN₃O₂
          ReversibleY
          Structure formula Image
          Applications
          Biological Information
          Primary TargetGSK-3α/β
          Primary Target IC<sub>50</sub>5 nM against GSK-3α/β
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 20/21/22

          Harmful by inhalation, in contact with skin and if swallowed.
          S PhraseS: 22-36/37

          Do not breathe dust.
          Wear suitable protective clothing and gloves.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          361550

          Referencias bibliográficas

          Visión general referencias
          Tseng, A-S., et al. 2006. Chem. Biol. 13, 957.
          Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
          Sato, N., et al. 2004. Nat. Med. 10, 55.
          Meijer, L., et al. 2003. Chem. Biol. 10, 1255.

          Citas

          Título
        • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.
        • Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-April-2008 RFH
          SynonymsBIO, (2ʹZ,3ʹE)-6-Bromoindirubin-3ʹ-oxime
          DescriptionA cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC50 = 5 nM). Specificity was confirmed using various Cdk's (IC50 = 83 nM for Cdk5/p25, 300 nM for Cdk2/cyclin A, 320 nM for Cdk1/cyclin B, and 10 µM for Cdk4/cyclin D1), MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK (IC50 ≥10 µM). Inhibition of GSK by BIO has been shown to result in the activation of the Wnt signaling pathway and sustained pluripotency of human and murine embryonic stem cells (ESCs). Reported to maintain self-renewal in human and mouse embryonic stem cells. Also induces the differentiation of neonatal cardiomyocytes.
          FormPurple solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number667463-62-9
          Chemical formulaC₁₆H₁₀BrN₃O₂
          Structure formula
          Purity≥97% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          ReferencesTseng, A-S., et al. 2006. Chem. Biol. 13, 957.
          Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
          Sato, N., et al. 2004. Nat. Med. 10, 55.
          Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
          Citation
        • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.